Prognostic value of inflammation-related model in hepatitis B acute-on-chronic liver failure DOI Creative Commons
Huimian Xu,

xue Li,

Yue Zhuo

et al.

Advances in Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 34(11), P. 0 - 0

Published: Nov. 18, 2024

Acute-on-chronic liver failure (ACLF) is characterized by rapid onset, development and a high short-term mortality rate. Systemic inflammation exerts an effect on the disease progression of ACLF.

Language: Английский

Hypermethylation of the glutathione peroxidase 4 promoter predicts poor prognosis in patients with hepatitis B virus-associated acute-on-chronic liver failure DOI Creative Commons
Xing Su,

Li‐Yan Han,

Jing Wang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: July 25, 2024

Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a syn-drome with high short-term mortality rate, and its prognosis critical in clinical management. This study aimed to investigate the significance of glutathione peroxidase 4 (GPX4) occurrence development HBV-ACLF prognostic value for 90-day mortality.

Language: Английский

Citations

0
New perspectives in the definition and classification of acute-on-chronic liver failure DOI Creative Commons
Manman Xu, Yu Chen

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Language: Английский

Citations

0
Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure DOI Creative Commons
Yu Xia,

Ruoqi Zhou,

Wenting Tan

et al.

eGastroenterology, Journal Year: 2024, Volume and Issue: 2(3), P. e100101 - e100101

Published: Oct. 1, 2024

The model for end-stage liver disease (MELD) score is widely used the prognostication in but has limited performance acute-on-chronic failure (ACLF). In this study, we identified additional predictive parameters and reformed MELD to predict ACLF more accurately. A meta-analysis was performed on relevant studies identify factors of 28-day/90-day outcomes ACLF, which were validated two large prospective cohorts. prognostic developed by incorporating into score. evaluated with a focus discrimination calibration. incorporated 32 cohort total 13 939 patients, risk identified, 3 (age, neutrophil count hepatic encephalopathy (HE) grade) besides 751 patients derived from new (Chinese Acute-on-Chronic Liver Failure Consortium (CATCH-LIFE)-MELD score) as follows: 0.028×age+0.3×HE grade+0.039×neutrophil count+0.079×MELD CATCH-LIFE-MELD achieved concordance index 0.791/0.788 outcomes, superior other traditional scores. Other indices, including net reclassification improvement, integrated improvement probability density function, calibration Nagelkerke's R2 Brier scores confirmed its superiority. Moreover, accuracy remained stable. It highest or without hepatitis B virus infection, cirrhosis, under Chinese Group Study Severe Hepatitis (COSSH) criteria European Association (EASL) criteria. All results substantiated an evaluation using external cohort. score, modified exhibited improved predicting short-term prognosis than

Language: Английский

Citations

0
Prognostic value of inflammation-related model in hepatitis B acute-on-chronic liver failure DOI Creative Commons
Huimian Xu,

xue Li,

Yue Zhuo

et al.

Advances in Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 34(11), P. 0 - 0

Published: Nov. 18, 2024

Acute-on-chronic liver failure (ACLF) is characterized by rapid onset, development and a high short-term mortality rate. Systemic inflammation exerts an effect on the disease progression of ACLF.

Language: Английский

Citations

0