Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Background
No
effective
therapies
exist
to
prevent
neurodegenerative
mild
cognitive
impairment
(MCI)
related
Alzheimer's
disease.
Therapies
integrating
music
and/or
dance
are
promising
non-pharmacological
options
effectively
mitigate
decline.
Objective
To
deepen
our
understanding
of
individuals’
relationships
(i.e.,
histories,
experiences,
and
attitudes)
with
dance,
in
order
incorporate
such
knowledge
into
the
design
music-
dance-based
interventions,
thereby
improving
therapeutic
outcomes.
Methods
Eleven
older
adults
MCI
five
their
care
partners/
spouses
(4
M/12F;
Black:
n
=
4,
White:
10,
Hispanic/Latino:
2;
Age:
71.4
±
9.6
years)
first
completed
questionnaires,
then
participated
focus
groups
that
captured
aspects
dance.
Emergent
themes
were
extracted
from
four
major
topics,
including:
(1)
experience
history,
(2)
enjoyment
preferences,
(3)
confidence
barriers,
(4)
impressions
as
tools.
Results
Thematic
analysis
revealed
participants’
positive
potential
citing
perceived
neuropsychological,
emotional,
physical
benefits.
Participants
viewed
integral
lives,
identities
within
a
culture,
family,
and/
or
community.
also
identified
lifelong
engagement
barriers
that,
conjunction
negative
feedback,
instilled
persistent
low
self-efficacy
regarding
dancing
active
engagement.
Questionnaires
verified
moderately-strong
relationships,
which
strongest
passive
forms
(e.g.,
listening).
Conclusions
Our
findings
support
associated
perceptions
toward
therapy
may
offer
valuable
insights
enhance
efficacious
engaging
for
individuals
MCI.
Artificial Intelligence and Applications,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 7, 2024
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
condition
characterized
by
cognitive
decline
and
functional
impairment.
This
study
compares
conventional
intervention
techniques
with
emerging
artificial
intelligence
(AI)
approaches
to
AD.
Intervention
technique
refers
specific
method
or
approach
employed
bring
about
positive
change
in
particular
situation.
In
the
context
of
AD,
such
are
crucial
as
they
aim
slow
down
progression
symptoms,
alleviate
behavioral
challenges,
support
patients
their
caretakers
managing
complexities
condition.
Conventional
techniques,
stimulation
reality
orientation,
have
demonstrated
benefits
improving
function
emotional
well-being.
widely
preferred
proven
track
record
effectiveness,
personalized
response,
cost-effectiveness,
patient-centered
care.
Despite
these
benefits,
limited
individual
variability
response
long-term
effectiveness.
On
other
hand,
AI-based
computer
vision
deep
learning
hold
potential
revolutionize
interventions.
These
technologies
offer
early
detection,
care,
remote
monitoring
capabilities.
They
can
provide
tailored
interventions,
assist
decision-making,
enhance
caregiver
support.
Although
interventions
face
challenges
data
privacy
implementation
complexity,
transform
care
significant.
research
paper
approaches.
It
reveals
that
while
traditional
well
established
novel
opportunities
for
advanced
Combining
strengths
both
may
lead
more
comprehensive
effective
individuals
Continued
collaboration
harness
full
AI
enhancing
quality
life
affected
caregivers.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 10, 2024
Abstract
To
maintain
current
cognitive
function
and
access
greater
reserves,
nonpharmacological
interventions
may
be
a
viable
alternative
for
older
adults
with
or
without
impairment.
This
study
aimed
to
compare
different
enhancing
global
cognition,
including
mind–body
exercise,
physical
non-invasive
brain
stimulation,
training
intervention
(CTI),
acutherapy
(ACU),
meditation,
music
therapy,
by
applying
network
meta-analysis
(NMA).
Sixty-one
randomized
controlled
trials
evaluating
the
efficacy
of
on
cognition
in
mild
decline
were
selected.
An
NMA
was
conducted
interventions.
The
revealed
that
exercise
(standardized
mean
difference,
1.384;
95%
confidence
interval,
0.777–1.992);
ACU
(1.283;
0.478–2.088);
meditation
(0.910;
0.097–1.724);
stimulation
(1.242;
0.254–2.230);
CTI
(1.269;
0.736–1.802);
(0.977;
0.212–1.742),
showed
positive
effects
compared
passive
controls.
There
no
significant
differences
between
efficacies
other
Nonpharmacological
potentially
enhance
through
various
pathways,
such
as
memorizing
movements
plasticity
reducing
stress
adult
population.
Additional
studies
are
needed
clarify
impact
variables,
methods
psychological
variables.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11720 - 11720
Опубликована: Окт. 31, 2024
Alzheimer's
disease
(AD)
presents
a
public
health
challenge
due
to
its
progressive
neurodegeneration,
cognitive
decline,
and
memory
loss.
The
amyloid
cascade
hypothesis,
which
postulates
that
the
accumulation
of
amyloid-beta
(Aβ)
peptides
initiates
leading
AD,
has
dominated
research
therapeutic
strategies.
failure
recent
Aβ-targeted
therapies
yield
conclusive
benefits
necessitates
further
exploration
AD
pathology.
This
review
proposes
Mitochondrial-Neurovascular-Metabolic
(MNM)
integrates
mitochondrial
dysfunction,
impaired
neurovascular
regulation,
systemic
metabolic
disturbances
as
interrelated
contributors
pathogenesis.
Mitochondrial
hallmark
leads
oxidative
stress
bioenergetic
failure.
Concurrently,
breakdown
blood-brain
barrier
(BBB)
cerebral
blood
flow,
characterize
dysregulation,
accelerate
neurodegeneration.
Metabolic
such
glucose
hypometabolism
insulin
resistance
impair
neuronal
function
survival.
hypothesis
highlights
interconnectedness
these
pathways
suggests
strategies
targeting
health,
integrity,
regulation
may
offer
more
effective
interventions.
MNM
addresses
multifaceted
aspects
providing
comprehensive
framework
for
understanding
progression
developing
novel
approaches.
approach
paves
way
innovative
could
significantly
improve
outcomes
millions
affected
worldwide.
Journal of Neuroscience,
Год журнала:
2024,
Номер
44(15), С. e1922232024 - e1922232024
Опубликована: Фев. 29, 2024
Music
is
a
universal
human
attribute.
The
study
of
amusia,
neurologic
music
processing
deficit,
has
increasingly
elaborated
our
view
on
the
neural
organization
musical
brain.
However,
lesions
causing
amusia
occur
in
multiple
brain
locations
and
often
also
cause
aphasia,
leaving
distinct
networks
for
unclear.
Here,
we
utilized
lesion
network
mapping
to
identify
these
networks.
A
systematic
literature
search
was
carried
out
all
published
case
reports
lesion-induced
amusia.
reproducibility
specificity
identified
were
then
tested
an
independent
prospective
cohort
97
stroke
patients
(46
female
51
male)
with
repeated
structural
imaging,
specifically
assessed
both
perception
language
abilities.
Lesion
heterogeneous
but
connected
common
regions,
including
bilateral
temporoparietal
insular
cortices,
precentral
gyrus,
cingulum.
In
cohort,
mapped
network,
centering
right
superior
temporal
cortex
clearly
from
causally
associated
aphasia.
Lesion-induced
longitudinal
effects
circuit
confirmed
as
reduction
gray
white
matter
volume,
which
correlated
severity
We
demonstrate
that
despite
heterogeneity
disrupting
processing,
there
network.
These
results
provide
evidence
substrate
differentiating
music-related
functions
language,
providing
testable
target
noninvasive
stimulation
treat
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
100(4), С. 1145 - 1159
Опубликована: Июль 12, 2024
Recent
research
has
shown
beneficial
results
for
music-based
interventions
(MBIs)
persons
living
with
Alzheimer's
disease
and
related
dementias
(AD/ADRD),
but
reports
often
lack
sufficient
detail
about
the
MBI
methodology,
which
reduces
replicability.
A
detailed
checklist
best
practices
in
how
to
report
MBIs
was
created
2011
by
Robb
colleagues
remedy
of
descriptions.
The
implementation
specifically
AD/ADRD
not
been
established.
Given
complexity
music
variety
uses
health,
specific
descriptions
are
necessary
rigorous
replication
validation
study
results.
Applied Neuropsychology Adult,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Янв. 17, 2025
This
study
evaluated
the
reliability
and
validity
of
In-Out-Test
for
detecting
episodic
memory
deficits
in
stroke
patients
explored
its
potential
as
a
clinical
test.
A
total
75
120
healthy
controls
underwent
tests,
including
Mini-Mental
State
Examination
(MMSE),
Montreal
Cognitive
Assessment
(MoCA),
Picture-Based
Memory
Impairment
Screen
(PMIS),
In-Out-Test.
Reliability
metrics
(Cronbach's
α,
inter-scorer
reliability,
test-retest
reliability),
criterion
validity,
corrected
item-total
correlation,
hierarchical
regression
analysis
ROC
curve
were
performed
to
determine
sensitivity
specificity
Stroke
scored
lower
across
all
tests
(p
<
0.001),
with
largest
difference
(d
=
0.99).
The
correlated
strongly
other
cognitive
(r
0.79-0.85
patients;
r
0.66-0.78
controls).
It
explained
an
additional
4.5%
variance
MoCA-MIS
scores
0.001).
was
high
α
0.835;
inter-rater
ICCs
0.911-0.925;
0.764-0.802).
showed
AUC
0.747,
0.708
0.680
at
cutoff
10.5.
Preliminary
findings
indicated
that
impairments
patients,
warranting
further
validation
larger
cohorts.
Aging & Mental Health,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Янв. 21, 2025
Due
to
the
limited
effectiveness
of
pharmacological
treatment,
there
is
a
growing
need
explore
non-pharmacological
psychosocial
interventions
such
as
music
therapy
when
treating
behavioural
and
psychological
symptoms
dementia
(BPSD).
We
randomised
57
nursing
home
residents
into
individual
active
plus
standard
care
(aMT),
receptive
with
tactile
sound
vibration
(rMT),
or
control
group
(CG).
A
trained
therapist
provided
12
sessions
over
6
weeks.
The
outcomes
(BPSD;
depression;
quality
life;
medical
system
usage;
activities
daily
living;
engagement)
were
measured
at
baseline
(0
week),
post-intervention
(6
weeks),
follow-up
(12
weeks).
results
indicated
small
beneficial
effects
for
BPSD
in
aMT
rMT
follow-up,
effect
total
musical
engagement
rMT,
negative
verbal
communication
usage
CG.
Both
methods
showed
promise
managing
increasing
during
therapy.
may
be
more
suited
advanced
stages
dementia.
Future
studies
should
evaluate
appropriateness
each
intervention
according
disease
severity.
Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 3, 2025
As
life
becomes
more
stressful,
neurological
disorders,
psychiatric
and
comorbidities
of
the
two
are
becoming
a
concern.
Multiple
neuropsychiatric
disorders
share
same
mental
somatic
dysfunction
may
involve
common
brain
circuits
mechanistic
targets.
Music
therapy,
as
an
art
form
with
proven
efficacy,
low
cost
few
side
effects,
is
promoted
for
use
in
interventions
disorders.
This
be
closely
related
to
release
signaling
molecules
such
monoamine
neurotransmitters,
glutamatergic
system,
gut-microbiota-brain
axis,
pro-inflammatory
cytokines
endogenous
opioid
peptide
system.
However,
fewer
studies
have
mentioned
main
targets
music
promote
functional
changes
regions.
Therefore,
this
paper
review
mechanisms
by
which
therapy
interacts
prefrontal
cortex-hippocampus-amygdala
circuit
through
aforementioned
molecules.
It
also
hypothesized
that
glial
cells,
mitochondria
microRNAs
microscopic
musical
intervention
The
aim
give
new
ideas
future
research
into
biological
