Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 11, 2025

Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), Multiple Sclerosis (MS), and Huntington’s (HD), although distinct in their clinical manifestations, share a common hallmark: disrupted neuroinflammatory environment orchestrated by dysregulation of neuroglial intercellular communication. Neuroglial crosstalk is physiologically ensured extracellular mediators the activity connexins (Cxs), forming proteins gap junctions (Gjs) hemichannels (HCs), which maintain intracellular homeostasis. However, accumulating evidence suggests that Cxs can also act pathological pore conditions, thereby contributing to neurodegenerative phenomena synaptic dysfunction, oxidative stress, ultimately cell death. This review explores mechanistic insights Cxs-mediated communication progression diseases discusses therapeutic potential targeting restore cellular

Язык: Английский

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Astrocyte-Mediated Neuroinflammation in Neurological Conditions

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1204 - 1204

Опубликована: Сен. 25, 2024

Astrocytes are one of the key glial types central nervous system (CNS), accounting for over 20% total cells in brain. Extensive evidence has established their indispensable functions maintenance CNS homeostasis, as well broad involvement neurological conditions. In particular, astrocytes can participate various neuroinflammatory processes, e.g., releasing a repertoire cytokines and chemokines or specific neurotrophic factors, which result both beneficial detrimental effects. It become increasingly clear that such astrocyte-mediated neuroinflammation, together with its complex crosstalk other immune cells, designates neuronal survival functional integrity neurocircuits, thus critically contributing to disease onset progression. this review, we focus on current knowledge responses astrocytes, summarizing common features Moreover, highlight several vital questions future research promise novel insights into diagnostic therapeutic strategies against those debilitating diseases.

Язык: Английский

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Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

Опубликована: Янв. 15, 2025

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Язык: Английский

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Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

eLife, Год журнала: 2025, Номер 13

Опубликована: Фев. 5, 2025

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Язык: Английский

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Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease

Handbook of clinical neurology, Год журнала: 2025, Номер unknown, С. 9 - 44

Опубликована: Янв. 1, 2025

Язык: Английский

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Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders

Neuroscience Bulletin, Год журнала: 2024, Номер 40(9), С. 1315 - 1332

Опубликована: Март 11, 2024

Язык: Английский

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Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation

eLife, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Язык: Английский

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Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation

Опубликована: Авг. 6, 2024

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioral cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behavior fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte dysfunction. Genetic perturbation amygdala by either silencing these cells or reducing network was sufficient replicate cellular, synaptic, data provide mechanistic links Our reveal a role astrocytes tuning emotionally salient dysfunction generalisation. Further understanding are affected might offer new insights into long-term impact affective states.

Язык: Английский

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HD and SCA1: Tales from two 30-year journeys since gene discovery

Neuron, Год журнала: 2023, Номер 111(22), С. 3517 - 3530

Опубликована: Окт. 19, 2023

Язык: Английский

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Ion Channels and Ionotropic Receptors in Astrocytes: Physiological Functions and Alterations in Alzheimer’s Disease and Glioblastoma

Life, Год журнала: 2023, Номер 13(10), С. 2038 - 2038

Опубликована: Окт. 11, 2023

The human brain is composed of nearly one hundred billion neurons and an equal number glial cells, including macroglia, i.e., astrocytes oligodendrocytes, microglia, the resident immune cells brain. In last few decades, compelling evidence has revealed that are far more active complex than previously thought. particular, astrocytes, most abundant cell population, not only take part in development, metabolism, defense against pathogens insults, but they also affect sensory, motor, cognitive functions by constantly modulating synaptic activity. Not surprisingly, actively involved neurodegenerative diseases (NDs) other neurological disorders like tumors, which rapidly become reactive mediate neuroinflammation. Reactive acquire or lose specific differently modulate disease progression symptoms, impairments. Astrocytes express several types ion channels, K+, Na+, Ca2+ transient receptor potential channels (TRP), aquaporins, mechanoreceptors, anion whose properties partially understood, particularly small processes contact synapses. addition, ionotropic receptors for neurotransmitters. Here, we provide extensive up-to-date review roles astrocyte physiology pathology. As examples two different pathologies, focus on Alzheimer’s (AD), diffuse disorders, glioblastoma (GBM), common tumor. Understanding how participate NDs tumors necessary developing new therapeutic tools these increasingly conditions.

Язык: Английский

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