Post-acute sequelae of SARS-CoV-2 infection (Long COVID) in older adults

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Язык: Английский

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

Seminars in Thrombosis and Hemostasis, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Abstract Long coronavirus disease 2019 (COVID-19)—a postacute consequence of severe acute respiratory syndrome 2 infection—manifests with a broad spectrum relapsing and remitting or persistent symptoms as well varied levels organ damage, which may be asymptomatic present events such heart attacks strokes recurrent infections, hinting at complex underlying pathogenic mechanisms. Central to these is vascular dysfunction rooted in thrombotic endothelialitis. We review the scientific evidence that widespread endothelial (ED) leads chronic symptomatology. briefly examine molecular pathways contributing pathology provide detailed analysis how cellular processes underpin clinical picture. Noninvasive diagnostic techniques, flow-mediated dilation peripheral arterial tonometry, are evaluated for their utility identifying ED. then explore mechanistic, cellular-targeted therapeutic interventions potential treating Overall, we emphasize critical role health managing COVID highlight need early intervention prevent long-term dysfunction.

Язык: Английский

Long COVID Clinical Evaluation, Research and Impact on Society: A Global Expert Consensus

Опубликована: Янв. 1, 2024

Язык: Английский