Genomics,
Год журнала:
2021,
Номер
113(6), С. 3919 - 3934
Опубликована: Сен. 21, 2021
Obesity
is
a
complex
disease
with
multifactorial
causes,
and
its
prevalence
becoming
serious
health
crisis.
For
this
reason,
there
crucial
need
to
identify
novel
targets
players.
With
aim
in
mind,
we
analyzed
via
RNA-sequencing
the
subcutaneous
adipose
tissue
of
normal
weight
obesity-affected
women,
highlighting
differential
expression
two
tissues.
We
specifically
focused
on
long
non-coding
RNAs,
as
6
these
emerged
dysregulated
diseased-tissue
(COL4A2-AS2,
RPS21-AS,
PELATON,
ITGB2-AS1,
ACER2-AS
CTEPHA1).
each
them,
performed
both
thorough
silico
dissection
vitro
validation,
predict
their
function
during
adipogenesis.
report
lncRNAs
derived
stem
cells
differentiation
adipocytes
model
adipogenesis
potential
modulation
by
adipogenesis-related
transcription
factors
(C/EBPs
PPARγ).
Moreover,
inhibiting
CTEPHA1
investigated
impact
factors,
showing
significative
dysregulation
C/EBPα
expression.
Lastly,
dissected
subcellular
localization,
pathway
involvement
disease-correlation
for
coding
differentially
expressed
genes.
Together,
findings
highlight
transcriptional
deregulation
at
basis
obesity,
impacted
RNAs.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(13), С. 7488 - 7488
Опубликована: Июль 5, 2022
Long-chain
noncoding
RNAs
(lncRNAs)
are
that
do
not
code
for
proteins,
widely
present
in
eukaryotes.
They
regulate
gene
expression
at
multiple
levels
through
different
mechanisms
epigenetic,
transcription,
translation,
and
the
maturation
of
mRNA
transcripts
or
regulation
chromatin
structure,
compete
with
microRNAs
binding
to
endogenous
RNA.
Adipose
tissue
is
a
large
endocrine-rich
functional
mammals.
Excessive
accumulation
white
adipose
mammals
can
cause
metabolic
diseases.
However,
unlike
fat,
brown
beige
fats
release
energy
as
heat.
In
recent
years,
many
lncRNAs
associated
adipogenesis
have
been
reported.
The
molecular
how
continually
investigated.
this
review,
we
discuss
classification
according
their
transcriptional
location.
participate
also
discussed.
function
decoy
molecules
RNA
double-stranded
complexes,
among
other
functions,
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1778 - 1778
Опубликована: Фев. 19, 2025
In
recent
years,
“metabolic
dysfunction-associated
steatotic
liver
disease”
(MASLD)
has
been
proposed
to
better
connect
disease
metabolic
dysfunction,
which
is
the
most
common
chronic
worldwide.
MASLD
affects
more
than
30%
of
individuals
globally,
and
it
diagnosed
by
combination
hepatic
steatosis
obesity,
type
2
diabetes,
or
two
risk
factors.
begins
with
buildup
extra
fat,
often
greater
5%,
within
liver,
causing
hepatocytes
become
stressed.
This
can
proceed
a
severe
form,
steatohepatitis
(MASH),
in
20–30%
people,
where
inflammation
causes
tissue
fibrosis,
limits
blood
flow
over
time.
As
fibrosis
worsens,
MASH
may
lead
cirrhosis,
failure,
even
cancer.
While
pathophysiology
not
fully
known,
current
“multiple-hits”
concept
proposes
that
dietary
lifestyle
factors,
genetic
epigenetic
factors
contribute
elevated
oxidative
stress
inflammation,
fibrosis.
review
article
provides
an
overview
pathogenesis
evaluates
existing
therapies
as
well
pharmacological
drugs
are
currently
being
studied
clinical
trials
for
MASH.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(12), С. 9978 - 9978
Опубликована: Июнь 10, 2023
Adipogenesis
is
regarded
as
an
intricate
network
in
which
multiple
transcription
factors
and
signal
pathways
are
involved.
Recently,
big
efforts
have
focused
on
understanding
the
epigenetic
mechanisms
their
involvement
regulation
of
adipocyte
development.
Multiple
studies
investigating
regulatory
role
non-coding
RNAs
(ncRNAs)
adipogenesis
been
reported
so
far,
especially
lncRNA,
miRNA,
circRNA.
They
regulate
gene
expression
at
levels
through
interactions
with
proteins,
DNA,
RNA.
Exploring
mechanism
developments
field
RNA
may
provide
a
new
insight
to
identify
therapeutic
targets
for
obesity
related
diseases.
Therefore,
this
article
outlines
process
adipogenesis,
discusses
updated
roles
ncRNAs
development
adipocytes.
Life Sciences,
Год журнала:
2024,
Номер
340, С. 122459 - 122459
Опубликована: Фев. 1, 2024
The
inflammatory
response
in
acute
lung
injury/acute
respiratory
distress
syndrome
(ALI/ARDS)
is
heightened
obesity.
aim
of
this
study
was
to
investigate
whether
lncRNAs
are
involved
the
effects
obesity
on
injury
and
find
possible
effector
lncRNAs.
Neurobiology of Disease,
Год журнала:
2023,
Номер
178, С. 106030 - 106030
Опубликована: Фев. 2, 2023
Deregulation
of
transcription
in
the
pathogenesis
sporadic
Amyotrophic
Lateral
Sclerosis
(sALS)
is
taking
central
stage
with
RNA-sequencing
analyses
from
sALS
patients
tissues
highlighting
numerous
deregulated
long
non-coding
RNAs
(lncRNAs).
The
oncogenic
lncRNA
ZEB1-AS1
strongly
downregulated
peripheral
blood
mononuclear
cells
patients.
In
addition,
cancer-derived
cell
lines,
belongs
to
a
negative
feedback
loop
regulation
hsa-miR-200c,
acting
as
molecular
sponge
for
this
miRNA.
role
has
not
been
characterized
yet,
and
its
study
could
help
identifying
possible
disease-modifying
target.the
implication
ZEB1-AS1/ZEB1/hsa-miR-200c/BMI1
pathway
was
investigated
multiple
patients-derived
cellular
models
(patients-derived
induced
pluripotent
stem
cells-derived
neural
cells)
neuroblastoma
line
SH-SY5Y,
where
function
inhibited
via
RNA
interference.
Molecular
techniques
such
Real
Time
PCR,
Western
Blot
Immunofluorescence
were
used
assess
dysregulation.Our
results
show
dysregulation
signaling
involving
ZEB1-AS1/hsa-miR-200c/β-Catenin
These
validated
vitro
on
SH-SY5Y
silenced
expression
ZEB1-AS1.
Moreover,
we
found
an
increase
during
differentiation
aberrant
β-Catenin,
also
aggregation
impact
neurite
length.Our
support
describe
specifically
neuronal
differentiation,
suggesting
that
impairment
β-Catenin
alteration
phenotype
are
place.
World Allergy Organization Journal,
Год журнала:
2025,
Номер
18(3), С. 101040 - 101040
Опубликована: Март 1, 2025
BackgroundPrevious
studies
have
shown
that
high
body
mass
index
was
a
primary
risk
factor
for
asthma,
particularly
impacting
older
adults.
This
study
aimed
to
assess
the
spatial
and
temporal
trends
asthma
burden
attributable
in
adults
from
1990
2021
project
up
2050.MethodWe
extracted
data
Global
Burden
of
Disease
Study
population
aged
over
60
years
with
BMI.
Relevant
indicators
included
number
deaths,
disability-adjusted
life
years,
mortality,
rates
were
directly
standardized.
Spearman
rank
correlation
test
tested
against
Socio-demographic
Index
(SDI).
Decomposition
analysis
used
decompose
changes
according
structure,
growth,
epidemiologic
changes.
The
Bayesian
age-period-cohort
model
predict
burden.ResultsFrom
2021,
despite
downward
global
mortality
life-year
rates,
increase
by
69%
46%,
rising
43,628
cases
(95%
CI:
18,366–71
088)
1,223,969
526,972–1
945,426).
Age-standardized
more
severe
regions
lower
SDI,
such
as
Oceania.
Mortality
increased
age,
higher
observed
females
compared
males.
Population
growth
had
significant
impact
on
deaths
contributing
approximately
158%
222%,
respectively.
Asthma
will
continue
rise
101,252
2,941,172
2050.ConclusionThe
due
has
risen
significantly
is
expected
this
trend,
highlighting
importance
developing
public
health
strategies
address
issue.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
critical
regulators
in
stem
cell
biology,
influencing
cellular
functions
such
pluripotency,
differentiation,
and
self-renewal.
Their
unique
ability
to
modulate
gene
expression
at
multiple
levels—epigenetic,
transcriptional,
post-transcriptional—makes
lncRNAs
powerful
tools
for
controlling
fate.
In
regenerative
medicine,
understanding
the
roles
of
specific
can
enhance
therapeutic
approaches,
particularly
cell-based
tissue
repair
engineering.
By
modulating
lncRNA
activity,
researchers
potentially
direct
differentiation
toward
desired
lineages,
facilitating
development
functional
tissues
clinical
applications.
This
chapter
explores
how
influence
states,
highlights
current
research
therapies,
discusses
potential
future
applications
where
lncRNA-based
interventions
could
drive
advancements
engineering
medicine.
