Epigenetic Alterations in Pediatric Sleep Apnea DOI Open Access
Emily C. Cheung, Matthew W. Kay, Kathryn J. Schunke

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9523 - 9523

Published: Sept. 1, 2021

Pediatric obstructive sleep apnea has significant negative effects on health and behavior in childhood including depression, failure to thrive, neurocognitive impairment, behavioral issues. It is strongly associated with an increased risk for chronic adult disease such as obesity diabetes, accelerated atherosclerosis, endothelial dysfunction. Accumulating evidence suggests that adult-onset non-communicable diseases may originate from early life through a process by which insult applied at critical developmental window causes long-term the structure or function of organism. In recent years, there been interest role epigenetic mechanisms pathogenesis susceptibility. Epigenetic influence adaptive variability include histone modifications, non-coding RNAs, DNA methylation. This review will highlight what currently known about phenotypic associations modifications pediatric emphasize importance changes both modulators potential therapeutic targets.

Language: Английский

Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications DOI
Ola Elazazy,

Heba M. Midan,

Reem K. Shahin

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 246, P. 154512 - 154512

Published: May 9, 2023

Language: Английский

Citations

50
Current Therapeutic Landscape for Metabolic Dysfunction-Associated Steatohepatitis DOI Open Access

Arun George Devasia,

Adaikalavan Ramasamy, Chen Huei Leo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1778 - 1778

Published: Feb. 19, 2025

In recent years, “metabolic dysfunction-associated steatotic liver disease” (MASLD) has been proposed to better connect disease metabolic dysfunction, which is the most common chronic worldwide. MASLD affects more than 30% of individuals globally, and it diagnosed by combination hepatic steatosis obesity, type 2 diabetes, or two risk factors. begins with buildup extra fat, often greater 5%, within liver, causing hepatocytes become stressed. This can proceed a severe form, steatohepatitis (MASH), in 20–30% people, where inflammation causes tissue fibrosis, limits blood flow over time. As fibrosis worsens, MASH may lead cirrhosis, failure, even cancer. While pathophysiology not fully known, current “multiple-hits” concept proposes that dietary lifestyle factors, genetic epigenetic factors contribute elevated oxidative stress inflammation, fibrosis. review article provides an overview pathogenesis evaluates existing therapies as well pharmacological drugs are currently being studied clinical trials for MASH.

Language: Английский

Citations

2
LncRNA-Mediated Adipogenesis in Different Adipocytes DOI Open Access
Peiwen Zhang, Shuang Wu,

Yuxu He

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(13), P. 7488 - 7488

Published: July 5, 2022

Long-chain noncoding RNAs (lncRNAs) are that do not code for proteins, widely present in eukaryotes. They regulate gene expression at multiple levels through different mechanisms epigenetic, transcription, translation, and the maturation of mRNA transcripts or regulation chromatin structure, compete with microRNAs binding to endogenous RNA. Adipose tissue is a large endocrine-rich functional mammals. Excessive accumulation white adipose mammals can cause metabolic diseases. However, unlike fat, brown beige fats release energy as heat. In recent years, many lncRNAs associated adipogenesis have been reported. The molecular how continually investigated. this review, we discuss classification according their transcriptional location. participate also discussed. function decoy molecules RNA double-stranded complexes, among other functions,

Language: Английский

Citations

40
Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis DOI
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154773 - 154773

Published: Aug. 18, 2023

Language: Английский

Citations

24
Non-Coding RNAs and Adipogenesis DOI Open Access
Wenxiu Ru, Sihuan Zhang, Jianyong Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9978 - 9978

Published: June 10, 2023

Adipogenesis is regarded as an intricate network in which multiple transcription factors and signal pathways are involved. Recently, big efforts have focused on understanding the epigenetic mechanisms their involvement regulation of adipocyte development. Multiple studies investigating regulatory role non-coding RNAs (ncRNAs) adipogenesis been reported so far, especially lncRNA, miRNA, circRNA. They regulate gene expression at levels through interactions with proteins, DNA, RNA. Exploring mechanism developments field RNA may provide a new insight to identify therapeutic targets for obesity related diseases. Therefore, this article outlines process adipogenesis, discusses updated roles ncRNAs development adipocytes.

Language: Английский

Citations

12
Microarray analysis identifies lncFirre as a potential regulator of obesity-related acute lung injury DOI Creative Commons
Wenjing Tang, Siqi Wu, Yin Tang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 340, P. 122459 - 122459

Published: Feb. 1, 2024

The inflammatory response in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is heightened obesity. aim of this study was to investigate whether lncRNAs are involved the effects obesity on injury and find possible effector lncRNAs.

Language: Английский

Citations

4
Global burden of asthma attributable to high body mass index in older adults 1990–2021 and prediction to 2050: An analysis of Global Burden of Disease Study 2021 DOI Creative Commons
Zhikang Wang, Yifang Liu, Yilin Li

et al.

World Allergy Organization Journal, Journal Year: 2025, Volume and Issue: 18(3), P. 101040 - 101040

Published: March 1, 2025

BackgroundPrevious studies have shown that high body mass index was a primary risk factor for asthma, particularly impacting older adults. This study aimed to assess the spatial and temporal trends asthma burden attributable in adults from 1990 2021 project up 2050.MethodWe extracted data Global Burden of Disease Study population aged over 60 years with BMI. Relevant indicators included number deaths, disability-adjusted life years, mortality, rates were directly standardized. Spearman rank correlation test tested against Socio-demographic Index (SDI). Decomposition analysis used decompose changes according structure, growth, epidemiologic changes. The Bayesian age-period-cohort model predict burden.ResultsFrom 2021, despite downward global mortality life-year rates, increase by 69% 46%, rising 43,628 cases (95% CI: 18,366–71 088) 1,223,969 526,972–1 945,426). Age-standardized more severe regions lower SDI, such as Oceania. Mortality increased age, higher observed females compared males. Population growth had significant impact on deaths contributing approximately 158% 222%, respectively. Asthma will continue rise 101,252 2,941,172 2050.ConclusionThe due has risen significantly is expected this trend, highlighting importance developing public health strategies address issue.

Language: Английский

Citations

0
Long Non-Coding RNAs in Stem Cell Regulation and Regenerative Medicine: Stemness, Differentiation, and Therapeutic Innovation DOI Creative Commons

Melika Emarati,

Hossein Azizi, Nima Ghasemi

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Long non-coding RNAs (lncRNAs) have emerged as critical regulators in stem cell biology, influencing cellular functions such pluripotency, differentiation, and self-renewal. Their unique ability to modulate gene expression at multiple levels—epigenetic, transcriptional, post-transcriptional—makes lncRNAs powerful tools for controlling fate. In regenerative medicine, understanding the roles of specific can enhance therapeutic approaches, particularly cell-based tissue repair engineering. By modulating lncRNA activity, researchers potentially direct differentiation toward desired lineages, facilitating development functional tissues clinical applications. This chapter explores how influence states, highlights current research therapies, discusses potential future applications where lncRNA-based interventions could drive advancements engineering medicine.

Language: Английский

Citations

0
Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1 DOI Creative Commons
Federica Rey, Erika Maghraby, Letizia Messa

et al.

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 178, P. 106030 - 106030

Published: Feb. 2, 2023

Deregulation of transcription in the pathogenesis sporadic Amyotrophic Lateral Sclerosis (sALS) is taking central stage with RNA-sequencing analyses from sALS patients tissues highlighting numerous deregulated long non-coding RNAs (lncRNAs). The oncogenic lncRNA ZEB1-AS1 strongly downregulated peripheral blood mononuclear cells patients. In addition, cancer-derived cell lines, belongs to a negative feedback loop regulation hsa-miR-200c, acting as molecular sponge for this miRNA. role has not been characterized yet, and its study could help identifying possible disease-modifying target.the implication ZEB1-AS1/ZEB1/hsa-miR-200c/BMI1 pathway was investigated multiple patients-derived cellular models (patients-derived induced pluripotent stem cells-derived neural cells) neuroblastoma line SH-SY5Y, where function inhibited via RNA interference. Molecular techniques such Real Time PCR, Western Blot Immunofluorescence were used assess dysregulation.Our results show dysregulation signaling involving ZEB1-AS1/hsa-miR-200c/β-Catenin These validated vitro on SH-SY5Y silenced expression ZEB1-AS1. Moreover, we found an increase during differentiation aberrant β-Catenin, also aggregation impact neurite length.Our support describe specifically neuronal differentiation, suggesting that impairment β-Catenin alteration phenotype are place.

Language: Английский

Citations

9
Role of lncRNAs in pathophysiology of obesity DOI
Vikram Shettigar, Venkata Naga Srikanth Garikipati

Current Opinion in Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 100832 - 100832

Published: May 1, 2025

Language: Английский

Citations

0