The global prevalence of oral leukoplakia: a systematic review and meta-analysis from 1996 to 2022 DOI Creative Commons
Chang Zhang, Bingjie Li,

Xiamei Zeng

и другие.

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Сен. 6, 2023

Abstract Background Oral leukoplakia(OLK) is a common oral potentially malignant disorder. The global prevalence of solely OLK was published in 2003, while the varied among different studies. In recent years, large-scale summary and definition-related analyses obtain insufficient attention. This study aimed to perform systematic review studies leukoplakia assess predisposing factors its occurrence. Methods search terms ("Oral leukoplakia" OR leukoplakia) AND (prevalence incidence epidemiology) were searched databases (Pubmed, Embase, Scopus, Web Science) for from January 1996 until December 2022. estimated calculation risk bias analysis used STATA 16.0. Results We obtained 69 studies, including 1,263,028 participants, 28 countries, 6 continents. 1.39%, varying 0.12 33.33%. overall pooled 2.23% population-based 1.36% clinic-based population 9.10% specific populations. continents ranged 0.33 11.74% with statistical difference calculation. higher males than females. Those who smoked consumed alcohol had those did not. Conclusion Combining data determined as 1.39% pooling 3.41%. relatively consistent stable across definitions. A found males, aged over 60 years old, smokers, consumers. results included this revealed that various definitions continents, which may help developing treatment prevention strategies leukoplakia.

Язык: Английский

Oral Cancer Screening: Past, Present, and Future DOI Creative Commons
Saman Warnakulasuriya, Alexander Ross Kerr

Journal of Dental Research, Год журнала: 2021, Номер 100(12), С. 1313 - 1320

Опубликована: Май 26, 2021

Oral cancer is a major public health problem, and there an increasing trend for oral to affect young men women. Public awareness poor, many patients present with late-stage disease, contributing high mortality. often preceded by clinical premalignant phase accessible visual inspection, thus are opportunities earlier detection reduce morbidity Screening asymptomatic individuals systematic examinations detect the disease has been shown be feasible. A positive screen includes both potentially malignant disorders. We review key screening studies undertaken, including 1 randomized trial. of high-risk groups cost-effective. Strengths weaknesses presented help guide new research in primary care settings invigorated prospect using emerging technologies that may improve discriminatory accuracy case detection. Most national organizations, US Preventive Services Task Force, have so far not recommended population-based due lack sufficient evidence leads reduction Where resources high, opportunistic dental practices recommended, although paucity alarming. The results surveys suggest dentists do perform screenings, but only weak downstaging disease. low, feasibility workers tested, measures indicate good outcomes. reported literature based on round screening, whereas should continuous process. This identifies huge potential directions cancer.

Язык: Английский

Процитировано

274
Oral squamous cell carcinomas: state of the field and emerging directions DOI Creative Commons

Yunhan Tan,

Zhihan Wang,

Mengtong Xu

и другие.

International Journal of Oral Science, Год журнала: 2023, Номер 15(1)

Опубликована: Сен. 22, 2023

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of oral cavity. It accounts for approximately 90% malignancies and impairs appearance, pronunciation, swallowing, flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to Global Cancer Observatory (GCO), incidence will rise by 40% 2040, accompanied a growth in mortality. Persistent exposure various risk factors, including tobacco, alcohol, betel quid (BQ), human papillomavirus (HPV), lead development potentially malignant disorders (OPMDs), which are lesions with an increased developing into OSCC. Complex multifactorial, oncogenesis process involves genetic alteration, epigenetic modification, dysregulated tumor microenvironment. Although therapeutic interventions, such as chemotherapy, radiation, immunotherapy, nanomedicine, have been proposed prevent or treat OPMDs, understanding mechanism facilitate identification prognostic thereby improving efficacy treatment patients. This review summarizes mechanisms involved Moreover, current interventions methods OPMDs discussed comprehension provide several prospective outlooks fields.

Язык: Английский

Процитировано

259
Malignant transformation of oral leukoplakia: Systematic review and meta‐analysis of the last 5 years DOI
José M. Aguirre‐Urizar, Irene Lafuente‐Ibáñez de Mendoza, Saman Warnakulasuriya

и другие.

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 1881 - 1895

Опубликована: Фев. 19, 2021

Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate overall transformation OL and assess risk factors associated with published in last 5 years (2015-2020).We performed a bibliographic search PubMed, Scopus, Web Science, Embase, Cochrane databases keywords "oral leukoplakia", cancer", carcinoma" squamous cell carcinoma". Meta-analysis was conducted using random-effects model.Twenty-four studies were selected, that reported total 16,604 patients. Malignant proportion varied between 1.1% 40.8%. Female gender, non-homogeneous clinical type, presence epithelial dysplasia significantly related MT. Other previously suggested did not show significant results.The pooled MT 9.8% (95% CI: 7.9-11.7). It necessary continue conduct well-designed prospective clinicopathological on OL, uniform definition for reduce bias evaluating various

Язык: Английский

Процитировано

190
Oral epithelial dysplasia: Recognition, grading and clinical significance DOI
Edward Odell, Omar Kujan, Saman Warnakulasuriya

и другие.

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 1947 - 1976

Опубликована: Авг. 21, 2021

Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing risk malignant transformation in oral potentially disorders (OPMDs). Current views on molecular pathogenesis and histological interpretation features are described, use systems is discussed. Changes to current 2017 WHO criteria diagnosis proposed with emphasis architectural dysplasia. The predictive values three-grade binary summarised, categories reviewed, including lichenoid verrucous lesions, keratosis unknown significance, HPV-associated dysplasia, differentiated basaloid implications finding an biopsy clinical management discussed from pathologists' viewpoint.

Язык: Английский

Процитировано

173
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue DOI
Susan Müller, Wanninayake Mudiyanselage Tilakaratne

Head and Neck Pathology, Год журнала: 2022, Номер 16(1), С. 54 - 62

Опубликована: Март 21, 2022

Язык: Английский

Процитировано

151
Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer DOI Creative Commons
Pratima Kumari, Priyanka Debta, Anshuman Dixit

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Апрель 20, 2022

Graphical Abstract (A) A representative diagram of changes occurring in buccal mucosa due to exposure various carcinogenic factors. The red arrow shows the direction associated with progression oral cancer. (B) circular map chromosomes involve genetic alternation.

Язык: Английский

Процитировано

122
IARC Perspective on Oral Cancer Prevention DOI Open Access

Véronique Bouvard,

Suzanne Tanya Nethan, Deependra Singh

и другие.

New England Journal of Medicine, Год журнала: 2022, Номер 387(21), С. 1999 - 2005

Опубликована: Окт. 18, 2022

In a review of strategies for preventing oral cancer, an expert panel reports that the use tobacco (both smoking and smokeless), areca nut exposure, heavy alcohol consumption are major contributors to this illness.

Язык: Английский

Процитировано

87
Challenges in the Early Diagnosis of Oral Cancer, Evidence Gaps and Strategies for Improvement: A Scoping Review of Systematic Reviews DOI Open Access
Miguel Ángel González‐Moles, Manuel Aguilar-Ruiz, Pablo Ramos‐García

и другие.

Cancers, Год журнала: 2022, Номер 14(19), С. 4967 - 4967

Опубликована: Окт. 10, 2022

Oral cancer is a growing problem, accounting for 377,713 worldwide new cases per year, and 177,757 deaths annually representing 5-year mortality rate close to 50%, which considerable that has not decreased substantially in the last 40 years. The main cause of this high related diagnosis percentage oral cancers advanced stages (stages III IV) treatment complex, mutilating or disabling, ineffective. essential at late stage delay diagnosis, therefore, achievement objective improving prognosis involves reducing its diagnosis. reasons are complex involve several actors circumstances—patients, health care providers, services. In paper, we present results scoping review systematic reviews on diagnostic with aim better understand, based evidence, discuss depth, fact, identify evidence gaps formulate strategies improvement.

Язык: Английский

Процитировано

83
Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art DOI Open Access
Lara Nokovitch, Charles Maquet,

Frédéric Crampon

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(9), С. 3264 - 3264

Опубликована: Май 3, 2023

Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of mucosal linings upper aerodigestive tract, which includes oral cavity, pharynx, larynx, sinonasal cavities. There are many associated risk factors, including alcohol drinking coupled with tobacco use, accounts for 70% to 80% HNSCCs. Human papilloma virus (HPV) is another independent factor oropharyngeal SCC, but it only a minor contributor cavity SCC (OSCC). Betel quid chewing also an established in southeast Asian countries. However, OSCC, especially tongue cancer, incidence has been reported be increasing several countries, suggesting factors that have not identified yet. This review summarizes examines other undemonstrated HNSCC.

Язык: Английский

Процитировано

50
Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review DOI Open Access

Daniel Bastías,

Alejandro Maturana,

Constanza Celia Nieto Marín

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2634 - 2634

Опубликована: Фев. 23, 2024

Different efforts have been made to find better and less invasive methods for the diagnosis prediction of oral cancer, such as study saliva a source biomarkers. The aim this was perform scoping review about salivary molecules that assessed possible biomarkers squamous cell carcinoma (OSCC). A search conducted using EBSCO, PubMed (MEDLINE), Scopus, Web Science. research question follows: which present in utility be used early detection cancer? Sixty-two studies were included. Over 100 assessed. Most markers oriented towards OSCC classified based on their ability detecting potentially malignant disorders (OPMDs), outcome prediction, transformation OPMDs. TNF-α, IL-1β, IL-6 IL-8, LDH, MMP-9 most studied, with almost all reporting high sensitivity specificity values. are promising However, more larger cohorts needed before translating use these clinical settings.

Язык: Английский

Процитировано

20