AIP conference proceedings, Год журнала: 2023, Номер 2822, С. 020028 - 020028
Опубликована: Янв. 1, 2023
Язык: Английский
Chemosphere, Год журнала: 2023, Номер 344, С. 140264 - 140264
Опубликована: Сен. 25, 2023
Язык: Английский
Процитировано
50
Life Sciences, Год журнала: 2023, Номер 330, С. 122007 - 122007
Опубликована: Авг. 5, 2023
Язык: Английский
Процитировано
36
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Май 3, 2024
Abstract The onerous health and economic burden associated with head neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of novel surgical techniques therapeutic protocols, there an incessant need for efficacious diagnostic targets to monitor invasion, metastasis recurrence HNSCC due its substantial morbidity mortality. differential expression patterns histone deacetylases (HDACs), group enzymes responsible modifying histones regulating gene expression, have been demonstrated in neoplastic tissues. However, limited knowledge regarding role HDACs HNSCC. Consequently, this review aims summarize existing research findings explore potential association between HNSCC, offering fresh perspectives on approaches targeting that could potentially enhance efficacy treatment. Additionally, Cancer Genome Atlas (TCGA) dataset, CPTAC, HPA, OmicShare, GeneMANIA STRING databases are utilized provide supplementary evidence HDACs, their prognostic significance predicting functions patients. Graphical
Язык: Английский
Процитировано
10
Medical Oncology, Год журнала: 2022, Номер 39(11)
Опубликована: Авг. 16, 2022
Язык: Английский
Процитировано
26
Experimental and Therapeutic Medicine, Год журнала: 2023, Номер 25(4)
Опубликована: Март 7, 2023
Collagen type IV α1 chain (COL4A1) is a collagen protein that acts as tumor-promoting factor in several types of cancer. However, the role and potential mechanisms involving COL4A1 oral squamous cell carcinoma (OSCC) remain unclear. Using reverse transcription-quantitative PCR western blotting, expression levels (nidogen-1) NID1 OSCC cells were assessed. Cell Counting Kit-8, EdU staining colony formation assays used to evaluate proliferation. migration invasion assessed using wound healing Transwell assays, respectively. The proteins involved epithelial-mesenchymal transition (EMT) blotting. In addition, association between was analyzed TNMplot STRING database verified by co-immunoprecipitation analysis. found be significantly increased cells. Knockdown decreased SCC-4 proliferation, invasion, well progression EMT. shown positively associated with bind NID1. overexpression reversed inhibitory effects knockdown on EMT summary, present findings demonstrated promoted proliferation binding NID1, highlighting avenue for therapeutic management OSCC.
Язык: Английский
Процитировано
11
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Фев. 11, 2024
Background The value and use of medicinal plants, including the widespread cultivation Rosmarinus officinalis, have increased rapidly. R. a plant native to Mediterranean, has received attention for its potential therapeutic benefits. This study evaluates officinalis anticancer activity using human epithelial carcinoma (KB) cell lines derived from nasopharyngeal epidermoid carcinoma. KB line is known sensitivity specific chemotherapeutic agents (CA), making it useful model in cancer research. impact assessed comprehensive analyses viability gene expression. Aim aims evaluate anti-cancer effects on lines. Materials methods leaf extract was separated used treat treated cells determined 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Real-time polymerase chain reaction (RT-PCR) analyze expressions matrix metalloproteinase (MMP-9) tumor-inducing metalloproteins (TIMP-1) messenger ribonucleic acid (mRNA) genes. statistical analysis performed. Results analyzes properties results show that increasing concentration rosemary reduces malignant cells. Furthermore, effect apoptotic signaling system demonstrated by decrease MMP-9 TIMP-1 mRNA expressions, as observed RT-PCR analysis. Conclusion Patients looking natural treatments may benefit biogenically prepared drugs. current research focuses alternative chemically synthesized
Язык: Английский
Процитировано
2
Deleted Journal, Год журнала: 2024, Номер 245(1)
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2023, Номер 25(1), С. 497 - 497
Опубликована: Дек. 29, 2023
SIRT6 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, predominantly located in the nucleus, that involved processes of histone modification, DNA repair, cell cycle regulation, and apoptosis. Disturbances expression levels have been observed development progression various types cancer. Therefore, it important to better understand role biochemical pathways assign specific biological functions. This review aims summarize carcinogenesis tumor development. A understanding factors influencing its may help develop novel anti-cancer therapeutic strategies. Moreover, we discuss effects mechanism action small molecule modulators (both activators inhibitors) different
Язык: Английский
Процитировано
5
Anti-Cancer Agents in Medicinal Chemistry, Год журнала: 2023, Номер 24(1), С. 3 - 17
Опубликована: Ноя. 22, 2023
Matrix metalloproteinases (MMPs) are proteolytic enzymes that aid in extracellular matrix (ECM) remodeling. MMPs destroy the matrix, causing tumor growth and metastasis. involved spread metastasis of oral cancer. High levels squamous cell carcinoma have been linked to cancer prognosis. Modern medicine aims prevent illness from spreading through early intervention examining changes MMP genes. gene polymorphism has recently identified as one factors predicting susceptibility or risk development carcinoma. This review provide insight into function subtypes The genetic genes its predictive value evaluation elaborated. Novel personalized therapeutic approaches for cancer, like use inhibitors, nanoparticle-mediated targeting MMP, silencing by microRNA, can be designed.
Язык: Английский
Процитировано
4
Deleted Journal, Год журнала: 2024, Номер 245(1)
Опубликована: Ноя. 22, 2024
Nanoparticles represent an emerging generation of materials that garnered substantial attention in research endeavors. Increasingly, compelling evidence supports the notion nanoparticles exhibit superior aptitude diverse heat transfer applications compared to traditional fluids. The specific category dispersed within foundational fluid is pivotal influencing these fluids' thermal characteristics. impact on solar collector efficiency investigated detail this research. It shows while carbon-based nanofluids are excellent at increasing conductivity, base fluids can have their increased by up 28% when metal oxide nanoparticles, such as Al2O3, added. Additionally, analysis clarifies which types best suited for different applications, highlighting areas need more research, like creation hybrid maximize stability and performance. main conclusions outlined, prospective directions further investigation offered. It's critical emphasize review focuses use a nanoparticle.
Язык: Английский
Процитировано
1