A state-of-art-review on emerging contaminants: Environmental chemistry, health effect, and modern treatment methods

Chemosphere, Journal Year: 2023, Volume and Issue: 344, P. 140264 - 140264

Published: Sept. 25, 2023

Language: Английский

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The crosstalk between Nrf2 and NF-κB pathways in coronary artery disease: Can it be regulated by SIRT6?

Life Sciences, Journal Year: 2023, Volume and Issue: 330, P. 122007 - 122007

Published: Aug. 5, 2023

Language: Английский

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Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 3, 2024

Abstract The onerous health and economic burden associated with head neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of novel surgical techniques therapeutic protocols, there an incessant need for efficacious diagnostic targets to monitor invasion, metastasis recurrence HNSCC due its substantial morbidity mortality. differential expression patterns histone deacetylases (HDACs), group enzymes responsible modifying histones regulating gene expression, have been demonstrated in neoplastic tissues. However, limited knowledge regarding role HDACs HNSCC. Consequently, this review aims summarize existing research findings explore potential association between HNSCC, offering fresh perspectives on approaches targeting that could potentially enhance efficacy treatment. Additionally, Cancer Genome Atlas (TCGA) dataset, CPTAC, HPA, OmicShare, GeneMANIA STRING databases are utilized provide supplementary evidence HDACs, their prognostic significance predicting functions patients. Graphical

Language: Английский

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Differential molecular mechanistic behavior of HDACs in cancer progression

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(11)

Published: Aug. 16, 2022

Language: Английский

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COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1

Experimental and Therapeutic Medicine, Journal Year: 2023, Volume and Issue: 25(4)

Published: March 7, 2023

Collagen type IV α1 chain (COL4A1) is a collagen protein that acts as tumor-promoting factor in several types of cancer. However, the role and potential mechanisms involving COL4A1 oral squamous cell carcinoma (OSCC) remain unclear. Using reverse transcription-quantitative PCR western blotting, expression levels (nidogen-1) NID1 OSCC cells were assessed. Cell Counting Kit-8, EdU staining colony formation assays used to evaluate proliferation. migration invasion assessed using wound healing Transwell assays, respectively. The proteins involved epithelial-mesenchymal transition (EMT) blotting. In addition, association between was analyzed TNMplot STRING database verified by co-immunoprecipitation analysis. found be significantly increased cells. Knockdown decreased SCC-4 proliferation, invasion, well progression EMT. shown positively associated with bind NID1. overexpression reversed inhibitory effects knockdown on EMT summary, present findings demonstrated promoted proliferation binding NID1, highlighting avenue for therapeutic management OSCC.

Language: Английский

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Anticancer Effects of Rosmarinus officinalis Leaf Extract on KB Cell Lines

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 11, 2024

Background The value and use of medicinal plants, including the widespread cultivation Rosmarinus officinalis, have increased rapidly. R. a plant native to Mediterranean, has received attention for its potential therapeutic benefits. This study evaluates officinalis anticancer activity using human epithelial carcinoma (KB) cell lines derived from nasopharyngeal epidermoid carcinoma. KB line is known sensitivity specific chemotherapeutic agents (CA), making it useful model in cancer research. impact assessed comprehensive analyses viability gene expression. Aim aims evaluate anti-cancer effects on lines. Materials methods leaf extract was separated used treat treated cells determined 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Real-time polymerase chain reaction (RT-PCR) analyze expressions matrix metalloproteinase (MMP-9) tumor-inducing metalloproteins (TIMP-1) messenger ribonucleic acid (mRNA) genes. statistical analysis performed. Results analyzes properties results show that increasing concentration rosemary reduces malignant cells. Furthermore, effect apoptotic signaling system demonstrated by decrease MMP-9 TIMP-1 mRNA expressions, as observed RT-PCR analysis. Conclusion Patients looking natural treatments may benefit biogenically prepared drugs. current research focuses alternative chemically synthesized

Language: Английский

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Nanoparticles influence on performance and combustion enhancement of biodiesels in Ci engines: mini review

Deleted Journal, Journal Year: 2024, Volume and Issue: 245(1)

Published: Sept. 30, 2024

Language: Английский

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The Role of Sirtuin 6 in the Deacetylation of Histone Proteins as a Factor in the Progression of Neoplastic Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 497 - 497

Published: Dec. 29, 2023

SIRT6 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, predominantly located in the nucleus, that involved processes of histone modification, DNA repair, cell cycle regulation, and apoptosis. Disturbances expression levels have been observed development progression various types cancer. Therefore, it important to better understand role biochemical pathways assign specific biological functions. This review aims summarize carcinogenesis tumor development. A understanding factors influencing its may help develop novel anti-cancer therapeutic strategies. Moreover, we discuss effects mechanism action small molecule modulators (both activators inhibitors) different

Language: Английский

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Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(1), P. 3 - 17

Published: Nov. 22, 2023

Matrix metalloproteinases (MMPs) are proteolytic enzymes that aid in extracellular matrix (ECM) remodeling. MMPs destroy the matrix, causing tumor growth and metastasis. involved spread metastasis of oral cancer. High levels squamous cell carcinoma have been linked to cancer prognosis. Modern medicine aims prevent illness from spreading through early intervention examining changes MMP genes. gene polymorphism has recently identified as one factors predicting susceptibility or risk development carcinoma. This review provide insight into function subtypes The genetic genes its predictive value evaluation elaborated. Novel personalized therapeutic approaches for cancer, like use inhibitors, nanoparticle-mediated targeting MMP, silencing by microRNA, can be designed.

Language: Английский

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Implications of altered sirtuins in metabolic regulation and oral cancer

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e14752 - e14752

Published: Feb. 14, 2023

Sirtuins (SIRTs 1-7) are a group of histone deacetylase enzymes with wide range enzyme activities that target cellular proteins in the nucleus, cytoplasm, and mitochondria for posttranslational modifications by acetylation (SIRT1, 2, 3, 5) or ADP ribosylation (SIRT4, 6, 7). A variety functions, including mitochondrial functions energy homeostasis, metabolism, cancer, longevity ageing, regulated sirtuins. Compromised sirtuin and/or alterations expression levels sirtuins may lead to several pathological conditions contribute significantly metabolic phenotypes as well oral carcinogenesis. Here, we describe basic characteristics seven mammalian This review also emphasizes key molecular mechanisms regulation discusses possible relationships cancers. will provide novel insight into new therapeutic approaches targeting potentially effective strategies combating malignancies.

Language: Английский

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