WHO Classification of Tumours

Опубликована: Окт. 4, 2024

Язык: Английский

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Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue

Head and Neck Pathology, Год журнала: 2022, Номер 16(1), С. 54 - 62

Опубликована: Март 21, 2022

Язык: Английский

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Challenges in the Early Diagnosis of Oral Cancer, Evidence Gaps and Strategies for Improvement: A Scoping Review of Systematic Reviews

Cancers, Год журнала: 2022, Номер 14(19), С. 4967 - 4967

Опубликована: Окт. 10, 2022

Oral cancer is a growing problem, accounting for 377,713 worldwide new cases per year, and 177,757 deaths annually representing 5-year mortality rate close to 50%, which considerable that has not decreased substantially in the last 40 years. The main cause of this high related diagnosis percentage oral cancers advanced stages (stages III IV) treatment complex, mutilating or disabling, ineffective. essential at late stage delay diagnosis, therefore, achievement objective improving prognosis involves reducing its diagnosis. reasons are complex involve several actors circumstances—patients, health care providers, services. In paper, we present results scoping review systematic reviews on diagnostic with aim better understand, based evidence, discuss depth, fact, identify evidence gaps formulate strategies improvement.

Язык: Английский

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An Evidence-Based Update on the Potential for Malignancy of Oral Lichen Planus and Related Conditions: A Systematic Review and Meta-Analysis

Cancers, Год журнала: 2024, Номер 16(3), С. 608 - 608

Опубликована: Янв. 31, 2024

A systematic review and a meta-analysis is presented on published articles the malignant transformation of oral lichen planus (OLP) related conditions, which, based current evidence, updates an earlier by our research group that included publications until November 2018. In this updated study (Nov-2023) we searched MEDLINE, Embase, Web Science, Scopus. We evaluated methodological quality studies (QUIPS tool) carried out meta-analyses. The inclusion criteria were met 101 (38,083 patients), 20 new primary-level (11,512 patients) in last 5 years added to study. pooled ratio was 1.43% (95% CI = 1.09-1.80) for OLP; 1.38% 0.16-3.38) lichenoid lesions; 1.20% 0.00-4.25) reactions; 5.13% 1.90-9.43) OLP with dysplasia. No significant differences found between OLL or LR groups subgroup (

Язык: Английский

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Management of oral potentially malignant disorders

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 2008 - 2025

Опубликована: Июль 29, 2021

Patients with oral potentially malignant disorders (OPMDs), including leukoplakia and erythroplakia, proliferative verrucous leukoplakia, submucous fibrosis, lichen planus/lichenoid lesions, can be challenging to manage. A small proportion will undergo cancer development determining a patient's risk is key making management decisions. Yet, our understanding of the natural history OPMDs has not been fully elucidated, precision approach based on integration numerous predictive markers validated by prospective studies. Evidence-based health promotion clinicians healthcare systems embraced universally. Medical surgical interventions evaluated rigorous research measuring important endpoints, such as development, mortality, or survival, are difficult expensive run. Most these studies employ non-ideal surrogate endpoints have deep methodologic flaws. Diagnostic criteria for enrolling subjects uniform, patients highest comprise proportions those enrolled. Few explore quality life patient preferences. It time rethink how we patients, across each OPMD, considering infrastructure cost-effectiveness. Global networks well-characterized populations well-designed interventional trials using outcome measures needed.

Язык: Английский

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Depression, anxiety, and stress in oral lichen planus: a systematic review and meta-analysis

Clinical Oral Investigations, Год журнала: 2021, Номер 26(2), С. 1391 - 1408

Опубликована: Авг. 30, 2021

Abstract Objectives We present this systematic review and meta-analyses to evaluate current evidence on the prevalence of depression, anxiety, stress in patients with oral lichen planus their magnitude association. Material methods searched PubMed, Embase, Web Science, Scopus, PsycInfo, Google Scholar for studies published before January 2021. evaluated quality using a specific method reviews addressing questions, designed by Joanna Briggs Institute. carried out performed heterogeneity, subgroups, meta-regression, small-study effects analyses. Results Fifty-one (which recruited 6,815 patients) met inclusion criteria. Our results reveal high depression (31.19%), anxiety (54.76%), (41.10%) planus. Furthermore, OLP presented significantly higher relative frequency than control group without (OR = 6.15, 95% CI 2.73–13.89, p < 0.001), 3.51, 2.10–5.85, 3.64, 1.48–8.94, 0.005), showing large effect sizes. Subgroups showed relevance participation psychologists psychiatrists diagnosis OLP. Multivariable meta-regression analysis importance comorbidity depression-anxiety Conclusions meta-analysis show that suffer stress, being more frequent general population. Clinical In dental clinic, especially dentists should be aware achieve correct referral.

Язык: Английский

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Oral Lichen Planus: An Update on Diagnosis and Management

American Journal of Clinical Dermatology, Год журнала: 2023, Номер 25(1), С. 35 - 53

Опубликована: Сен. 15, 2023

Язык: Английский

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Early Diagnosis of Oral Cancer: A Complex Polyhedral Problem with a Difficult Solution

Cancers, Год журнала: 2023, Номер 15(13), С. 3270 - 3270

Опубликована: Июнь 21, 2023

Oral and oropharyngeal cancers are a growing problem, accounting for 377,713 98,412 new cases per year all over the world 177,757 48,143 deaths annually, respectively. Despite substantial improvement in diagnostic procedures treatment techniques recent years, mortality rate has not decreased substantially last 40 which is still close to 50% of cases. The major cause responsible this high associated with percentage oral diagnosed advanced stages (stages III IV) where harbors poor efficacy, resulting challenges, mutilations, or disability. main reason cancer be at an stage delay, so it critical reduce delay order improve prognosis patients suffering from cancer. causes complex concern patients, healthcare professionals, services. In manuscript, critically reviewed based on current evidence, as well their causes, problems, potential strategies.

Язык: Английский

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Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review

Cancers, Год журнала: 2024, Номер 16(8), С. 1550 - 1550

Опубликована: Апрель 18, 2024

Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes cancer, death rates lip cavity cancer have remained stagnant three decades. Evidence shows that only small fraction of cancers are in fact preceded by OPMDs, most OPMDs an annual transformation rate less than 1%. As encompass very heterogeneous group conditions, it could be argued patients with mucosal diseases bearing substantial risk warrant close surveillance treatment, these include proliferative leukoplakia, erythroplakia, non-homogeneous well presenting severe dysplasia at biopsy. In this narrative review, I discuss intricate epidemiology malignancies we colloquially refer to explore limitations focusing reduce incidence mortality argue may-be label represents overdiagnosis OPMDs.

Язык: Английский

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Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults

Cochrane library, Год журнала: 2021, Номер 2021(12)

Опубликована: Дек. 10, 2021

Язык: Английский

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