Comprehensive Insight into Lichen Planus Immunopathogenesis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 3038 - 3038

Опубликована: Фев. 3, 2023

Lichen planus is a chronic disease affecting the skin, appendages, and mucous membranes. A cutaneous lichen rare occurring in less than 1% of general population, while oral illness up to five times more prevalent; still, both forms equally impair patient’s quality life. The etiology not entirely understood. Yet, immune-mediated mechanisms have been recognized since environmental factors such as hepatitis virus infection, mechanical trauma, psychological stress, or microbiome changes can trigger genetically susceptible individuals. According current understanding, immunopathogenesis caused by cell-mediated cytotoxicity, particularly cytotoxic T lymphocytes, whose activity further influenced Th1 IL-23/Th-17 axis. However, other immunocytes inflammatory pathways complement these mechanisms. This paper presents comprehensive insight into actual knowledge about planus, with causal genetic being discussed, described, principal effectors its circuits identified.

Язык: Английский

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Autoimmune disorders in oral lichen planus: A systematic review and meta‐analysis

Oral Diseases, Год журнала: 2022, Номер 29(4), С. 1382 - 1394

Опубликована: Янв. 9, 2022

Abstract Objectives The association of OLP with other autoimmune processes points to the possibility that OLP‐affected patients are actually developing an status predisposes them autoaggression against different targets. This systematic review and meta‐analysis aim evaluate current evidence on prevalence disorders in their magnitude association. Methods We searched PubMed, Embase, Web Science, Scopus databases for studies published before May 2021, no limitation regards publication date or language. evaluated quality studies, carried out meta‐analyses performed heterogeneity, subgroups, meta‐regression, small‐study effects analyses. Results Inclusion criteria were met by 153 (23,327 patients). Our results indicate existence high a frequent between some disorders, especially thyroid disease (PP = 7.96%, 95% CI 6.32–9.75; OR 1.99, 1.60–2.49, p < 0.001) diabetes mellitus 9.41%,95% 8.16–10.74; 1.64, 1.34–2.00, 0.001). Conclusions study demonstrates comorbidity diseases as well respectively. Quality should be upgraded (fibromyalgia, gastrointestinal rheumatic diseases, Sjogren's syndrome, lupus erythematosus, dermatological diseases) which data do not allow us know whether they really associated OLP.

Язык: Английский

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Oral bacteriome and oral potentially malignant disorders: A systematic review of the associations

Archives of Oral Biology, Год журнала: 2024, Номер unknown, С. 105891 - 105891

Опубликована: Янв. 1, 2024

Язык: Английский

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Oral lichen planus and related lesions. What should we accept based on the available evidence?

Oral Diseases, Год журнала: 2022, Номер 29(7), С. 2624 - 2637

Опубликована: Ноя. 13, 2022

Recent new terminologies have been proposed for lesions in the sphere of oral lichen planus (OLP) that theoretically present unique aetiological, clinical, prognostic or management characteristics different from those so-called typical forms OLP. We aimed to critically analyse what concepts and related OLP should we accept based on available evidence. A review literature was carried out order New include lichenoid lesions; contact reactions, drug reactions context graft-versus-host disease; chronic ulcerative stomatitis; pemphigoid; some are difficult categorise, such as with features proliferative verrucous leukoplakia upper labial mucosa. multidisciplinary, multicontinent working group has recently published a guideline recommendations modifying definitions associated disease, among which reasoned, evidence-based justification change is considered essential. An in-depth analysis newly terms OLP-related shows many them not justified. In this paper, set our position basis existing evidence appropriateness use these terms.

Язык: Английский

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Esophageal lichen planus: Current knowledge, challenges and future perspectives

World Journal of Gastroenterology, Год журнала: 2022, Номер 28(41), С. 5893 - 5909

Опубликована: Окт. 31, 2022

Lichen planus (LP) is a frequent, chronic inflammatory disease involving the skin, mucous membranes and/or skin appendages. Esophageal involvement in lichen (ELP) clinically important albeit underdiagnosed condition. This narrative review aims to give an overview of current knowledge on ELP, its prevalence, pathogenesis, clinical manifestation, diagnostic criteria, and therapeutic options order provide support management. Studies ELP were collected using PubMed/Medline. Relevant therapeutical characteristics from published patient cohorts including our own cohort extracted summarized. mainly affects middle-aged women. The principal symptom dysphagia. However, asymptomatic cases despite progressed macroscopic esophageal lesions may occur. pathogenesis unknown, however immune-mediated mechanism probable. Endoscopically, characterized by mucosal denudation tearing, trachealization, hyperkeratosis. Scarring stenosis occur courses. Histologic findings include detachment, T-lymphocytic infiltrations, epithelial apoptosis (Civatte bodies), dyskeratosis, Direct immuno-fluorescence shows fibrinogen deposits along basement membrane zone. To date, there no established therapy. treatment with topical steroids induces symptomatic histologic improvement two thirds patients general. More severe require therapy immunosuppressors. In stenosis, endoscopic dilation be necessary. regarded as precancerous condition transition squamous cell carcinoma has been documented literature. yet differential diagnosis for unclear dysphagia or esophagitis. Timely might prevent potential sequelae such development invasive carcinoma. Further studies are needed gain more about options.

Язык: Английский

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Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma: systematic review and meta-analysis

Medicina oral, patología oral y cirugía bucal, Год журнала: 2023, Номер unknown, С. e229 - e237

Опубликована: Янв. 1, 2023

Background: Oral lichen planus (OLP) is a prevalent autoimmune chronic inflammatory disease of unknown etiology.The importance the association between hepatic and OLP lies in fact that many these disorders (HC, HB, cirrhosis, steatosis) behave as risk factors for hepatocellular carcinoma.Material Methods: We searched PubMed, Embase, Web Science, Scopus studies published before January 2022.We evaluated quality (Joanna Briggs Institute tool).We performed meta-analyses, investigated heterogeneity studies, we also carried out subgroups, meta-regression, smallstudy effects analyses.146 (21,187 patients) were included this study.Our study aims to evaluate current evidence on prevalence magnitude diseases (especially those with malignancy), carcinoma OLP.Results: Our results suggest patients present significant tendency development hepatitis B (OR=1.62, 95%CI=1.01-2.40,p=0.02), C (OR=4.09, 95%CI=2.77-6.03,p<0.001), cirrhosis (OR=5.58,95%CI=1.83-16.96,p=0.002), steatosis (OR=5.71,95%CI=0.97-33.60,p=0.05) (OR=3.10,95%CI=1.14-8.43,p=0.03).Conclusions: Patients should be rule presence disease, which can lead carcinoma, allowing an early diagnosis would help better approach liver notable improvement prognosis terms both progression severity.

Язык: Английский

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Experimental and clinical trial investigations of phyto-extracts, phyto-chemicals and phyto-formulations against oral lichen planus: A systematic review

Journal of Ethnopharmacology, Год журнала: 2022, Номер 298, С. 115591 - 115591

Опубликована: Авг. 10, 2022

Язык: Английский

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Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome

Cancers, Год журнала: 2023, Номер 15(11), С. 3004 - 3004

Опубликована: Май 31, 2023

This study aims to retrospectively assess the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022, evaluate influence different factors. The department's database medical records from 2022 were searched for a confirmed diagnosis OLP based on both clinical histological parameters. A total 100 (59 females 41 males) found mean age 64.03 years. In considered period, percentage was 1.6%, while squamous cell carcinoma (OSCC) 0.18%. statistically significant difference (p = 0.038), tobacco status 0.022), radiotherapy 0.041). analysis revealed presence ex-smokers (>20 pack-years), an odds ratio (OR) 10.0000 (95% confidence interval CI) 1.5793-63.3186); alcohol-drinker patients, OR 4.0519 CI 1.0182-16.1253); ex-smoker 17.6250 2.2464-138.2808); who had undergone radiotherapy, 6.3000 1.2661-31.3484). slightly higher than thought, results possible association age, alcohol status, history radiotherapy. An elevated observed heavy smoking (ex-smokers). Persuading patient quit consumption periodic follow-ups are recommended general, but particularly these

Язык: Английский

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Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Clinical Oral Investigations, Год журнала: 2023, Номер 27(6), С. 3057 - 3069

Опубликована: Фев. 14, 2023

Abstract Objectives Oral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated complex symptomatology and psychological alteration. The aim the study was to evaluate prevalence anxiety (A) depression (D) in patients K-OLP, analyzing potential predictors which can affect mental health status. Methods Three hundred K-OLP versus 300 healthy controls (HC) were recruited 15 Italian universities. Numeric Rating Scale (NRS), Total Pain Index (T-PRI), Hamilton Scales for Depression Anxiety (HAM-D HAM-A) administered. Results showed statistically higher scores NRS, T-PRI, HAM-D, HAM-A compared HC ( p -value < 0.001 ** ). A D found 158 (52.7%) 148 (49.3%) patients. Strong linear correlations identified between HAM-A, employment status status, female gender. Multivariate logistic regression revealed HAM-D greatest increase R2 value patients, respectively (DR2 = 55.5% 0.001**; DR2 56.5% 0.001**). Conclusions HC, also subjects without pain, suggesting processing pain certain way independent mood. Clinical relevance Mood disorders assessment should carefully performed relation obtain complete analysis

Язык: Английский

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Hypertension in oral lichen planus: A systematic review and meta‐analysis

Oral Diseases, Год журнала: 2023, Номер 30(4), С. 1793 - 1805

Опубликована: Сен. 19, 2023

Abstract Objectives To perform a systematic review and meta‐analysis in order to qualitatively quantitatively evaluate the prevalence magnitude of association hypertension patients with oral lichen planus (OLP). Methods MEDLINE, Embase, Scopus, Web Science databases were searched for studies published before May 2022, not restricted by publication language or date. The methodological quality risk bias primary‐level critically assessed. Meta‐analyses performed, as well meta‐regression, stratified, sensitivity small‐study effects analyses, Galbraith (radial) plot, trial sequential analysis. Quality evidence was evaluated using GRADE system. Results 104 studies, including 16,587 patients, met inclusion criteria. results show that who suffer from OLP have high (PP = 24.17%, 95% CI 21.45–27.00), low evidence. A significant between also reported (OR 1.28, 1.01–1.63, p 0.04), showing moderate Conclusions Patients could be at an increased suffering which is probably due multiple factors. Healthcare practitioners involved management should aware this comorbidity apply suitable measures make referrals if suspected, although further research needed.

Язык: Английский

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