Malignant transformation of oral leukoplakia: Systematic review and meta‐analysis of the last 5 years

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 1881 - 1895

Опубликована: Фев. 19, 2021

Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate overall transformation OL and assess risk factors associated with published in last 5 years (2015-2020).We performed a bibliographic search PubMed, Scopus, Web Science, Embase, Cochrane databases keywords "oral leukoplakia", cancer", carcinoma" squamous cell carcinoma". Meta-analysis was conducted using random-effects model.Twenty-four studies were selected, that reported total 16,604 patients. Malignant proportion varied between 1.1% 40.8%. Female gender, non-homogeneous clinical type, presence epithelial dysplasia significantly related MT. Other previously suggested did not show significant results.The pooled MT 9.8% (95% CI: 7.9-11.7). It necessary continue conduct well-designed prospective clinicopathological on OL, uniform definition for reduce bias evaluating various

Язык: Английский

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Oral epithelial dysplasia: Recognition, grading and clinical significance

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 1947 - 1976

Опубликована: Авг. 21, 2021

Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing risk malignant transformation in oral potentially disorders (OPMDs). Current views on molecular pathogenesis and histological interpretation features are described, use systems is discussed. Changes to current 2017 WHO criteria diagnosis proposed with emphasis architectural dysplasia. The predictive values three-grade binary summarised, categories reviewed, including lichenoid verrucous lesions, keratosis unknown significance, HPV-associated dysplasia, differentiated basaloid implications finding an biopsy clinical management discussed from pathologists' viewpoint.

Язык: Английский

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Challenges in the Early Diagnosis of Oral Cancer, Evidence Gaps and Strategies for Improvement: A Scoping Review of Systematic Reviews

Cancers, Год журнала: 2022, Номер 14(19), С. 4967 - 4967

Опубликована: Окт. 10, 2022

Oral cancer is a growing problem, accounting for 377,713 worldwide new cases per year, and 177,757 deaths annually representing 5-year mortality rate close to 50%, which considerable that has not decreased substantially in the last 40 years. The main cause of this high related diagnosis percentage oral cancers advanced stages (stages III IV) treatment complex, mutilating or disabling, ineffective. essential at late stage delay diagnosis, therefore, achievement objective improving prognosis involves reducing its diagnosis. reasons are complex involve several actors circumstances—patients, health care providers, services. In paper, we present results scoping review systematic reviews on diagnostic with aim better understand, based evidence, discuss depth, fact, identify evidence gaps formulate strategies improvement.

Язык: Английский

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An Evidence-Based Update on the Potential for Malignancy of Oral Lichen Planus and Related Conditions: A Systematic Review and Meta-Analysis

Cancers, Год журнала: 2024, Номер 16(3), С. 608 - 608

Опубликована: Янв. 31, 2024

A systematic review and a meta-analysis is presented on published articles the malignant transformation of oral lichen planus (OLP) related conditions, which, based current evidence, updates an earlier by our research group that included publications until November 2018. In this updated study (Nov-2023) we searched MEDLINE, Embase, Web Science, Scopus. We evaluated methodological quality studies (QUIPS tool) carried out meta-analyses. The inclusion criteria were met 101 (38,083 patients), 20 new primary-level (11,512 patients) in last 5 years added to study. pooled ratio was 1.43% (95% CI = 1.09-1.80) for OLP; 1.38% 0.16-3.38) lichenoid lesions; 1.20% 0.00-4.25) reactions; 5.13% 1.90-9.43) OLP with dysplasia. No significant differences found between OLL or LR groups subgroup (

Язык: Английский

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Management of oral potentially malignant disorders

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 2008 - 2025

Опубликована: Июль 29, 2021

Patients with oral potentially malignant disorders (OPMDs), including leukoplakia and erythroplakia, proliferative verrucous leukoplakia, submucous fibrosis, lichen planus/lichenoid lesions, can be challenging to manage. A small proportion will undergo cancer development determining a patient's risk is key making management decisions. Yet, our understanding of the natural history OPMDs has not been fully elucidated, precision approach based on integration numerous predictive markers validated by prospective studies. Evidence-based health promotion clinicians healthcare systems embraced universally. Medical surgical interventions evaluated rigorous research measuring important endpoints, such as development, mortality, or survival, are difficult expensive run. Most these studies employ non-ideal surrogate endpoints have deep methodologic flaws. Diagnostic criteria for enrolling subjects uniform, patients highest comprise proportions those enrolled. Few explore quality life patient preferences. It time rethink how we patients, across each OPMD, considering infrastructure cost-effectiveness. Global networks well-characterized populations well-designed interventional trials using outcome measures needed.

Язык: Английский

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On the Oral Microbiome of Oral Potentially Malignant and Malignant Disorders: Dysbiosis, Loss of Diversity, and Pathogens Enrichment

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3466 - 3466

Опубликована: Фев. 9, 2023

The role of dysbiosis in the development and progression oral potentially malignant disorders (OPMDs) remains largely unknown. Here, we aim to characterize compare microbiome homogeneous leucoplakia (HL), proliferative verrucous leukoplakia (PVL), squamous cell carcinoma (OSCC), OSCC preceded by PVL (PVL-OSCC). Fifty biopsies from HL (n = 9), 12), 10), PVL-OSCC 8), healthy 11) donors were obtained. sequence V3–V4 region 16S rRNA gene was used analyze composition diversity bacterial populations. In cancer patients, number observed amplicon variants (ASVs) lower Fusobacteriota constituted more than 30% microbiome. patients had a higher abundance Campilobacterota Proteobacteria any other group analyzed. A penalized regression performed determine which species able distinguish groups. is enriched Streptococcus parasanguinis, salivarius, Fusobacterium periodonticum, Prevotella histicola, Porphyromonas pasteri, Megasphaera micronuciformis; salivae, Campylobacter concisus, Dialister pneumosintes, Schaalia odontolytica; Capnocytophaga leadbetteri, sputigena, gingivalis, showae, Metamycoplasma salivarium, nanceiensis; Lachnospiraceae bacterium, Selenomonas shahii. There differential suffering OPMDs cancer. To best our knowledge, this first study comparing alterations these groups; thus, additional studies are needed.

Язык: Английский

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Early Diagnosis of Oral Cancer: A Complex Polyhedral Problem with a Difficult Solution

Cancers, Год журнала: 2023, Номер 15(13), С. 3270 - 3270

Опубликована: Июнь 21, 2023

Oral and oropharyngeal cancers are a growing problem, accounting for 377,713 98,412 new cases per year all over the world 177,757 48,143 deaths annually, respectively. Despite substantial improvement in diagnostic procedures treatment techniques recent years, mortality rate has not decreased substantially last 40 which is still close to 50% of cases. The major cause responsible this high associated with percentage oral diagnosed advanced stages (stages III IV) where harbors poor efficacy, resulting challenges, mutilations, or disability. main reason cancer be at an stage delay, so it critical reduce delay order improve prognosis patients suffering from cancer. causes complex concern patients, healthcare professionals, services. In manuscript, critically reviewed based on current evidence, as well their causes, problems, potential strategies.

Язык: Английский

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Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review

Cancers, Год журнала: 2024, Номер 16(8), С. 1550 - 1550

Опубликована: Апрель 18, 2024

Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes cancer, death rates lip cavity cancer have remained stagnant three decades. Evidence shows that only small fraction of cancers are in fact preceded by OPMDs, most OPMDs an annual transformation rate less than 1%. As encompass very heterogeneous group conditions, it could be argued patients with mucosal diseases bearing substantial risk warrant close surveillance treatment, these include proliferative leukoplakia, erythroplakia, non-homogeneous well presenting severe dysplasia at biopsy. In this narrative review, I discuss intricate epidemiology malignancies we colloquially refer to explore limitations focusing reduce incidence mortality argue may-be label represents overdiagnosis OPMDs.

Язык: Английский

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Significance of p53 overexpression in the prediction of the malignant transformation risk of oral potentially malignant disorders: A systematic review and meta-analysis

Oral Oncology, Год журнала: 2022, Номер 126, С. 105734 - 105734

Опубликована: Янв. 25, 2022

Язык: Английский

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State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature

Journal of Clinical Medicine, Год журнала: 2021, Номер 10(22), С. 5383 - 5383

Опубликована: Ноя. 18, 2021

Diabetes mellitus (DM) is a global health problem, having recognized that in the next 20 years number of diabetic patients world will increase to 642 million. DM exerts enormous repercussions on general (especially derived from vascular, cardiac, renal, ocular, or neurological affectation). It entails addition high deaths directly related disease, as well care cost, estimated at $673 billion annually. Oral cavity found among all organs and systems affected course DM. Important pathologies are developed with higher prevalence, such periodontitis (PD), alterations salivary flow, fungal infections, oral cancer, potentially malignant disorders (OPMD). has been proven PD hinders metabolic control presence increases possibility for developing diabetes. Despite relevance these pathologies, knowledge primary physicians diabetes specialists about importance diabetics, dentists scarce non-existent. accepted correct management requires interdisciplinary teams, including dentists. In this critical review, existing evidence-degree preventive, clinical, diagnosis, prognosis, therapeutic aspects diseases occur significant frequency population extension.

Язык: Английский

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