Journal of Asthma and Allergy,
Год журнала:
2025,
Номер
Volume 18, С. 363 - 375
Опубликована: Март 1, 2025
This
study
aimed
to
investigate
the
molecular
sensitization
patterns
of
cats,
dogs,
and
horses
in
patients
with
cat
and/or
dog
IgE
cross-reactivity
other
furry
animals.
In
95
diagnosed
allergic
diseases
sensitized
cats
dogs
(confirmed
by
specific
Immunoglobulin
E
(sIgE)
≥
0.35
kUA/L
crude
dander
extracts),
sIgE
levels
components
(Fel
d
1/2/4),
(Can
f
1/2/3/5),
horse
(Equ
c
1),
as
well
allergens
from
cow,
guinea
pig,
mouse,
rat,
rabbit,
chicken,
were
measured.
Sensitization
profiles
analyzed.
Inhibition
tests
using
serum
albumin
(SA)
lipocalin
proteins
performed.
rates
extracts
animals
ranged
16.8%
49.5%.
A
strong
positive
correlation
between
2
Can
3)
rabbit
epithelium,
mouse
pig
epithelium
rat
(rs:
0.66-0.87,
all
P
<
0.05),
while
family
4,
1,
Equ
1)
only
had
a
low
moderate
epithelial
above
four
0.36-0.65,
0.05).
Simultaneous
SA
these
animal
accounted
for
42.4%.
significantly
higher
SA-positive
groups
(all
0.05)
The
results
inhibition
test
showed
that
Fel
3
high
allergens,
ranging
66.5%
91.8%
75.8%
91.9%,
respectively.
When
used
inhibitors,
almost
lower
than
50%.
is
primary
driver
cross-sensitization
animals,
rather
lipocalins.
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics),
Год журнала:
2025,
Номер
70(1), С. 5 - 10
Опубликована: Март 5, 2025
Improvements
in
clinical
approaches
and
innovative
technological
solutions
the
field
of
molecular
allergy
diagnostics
have
fundamentally
changed
tactics
strategy
for
managing
children
with
allergic
diseases.
In
particular,
is
used
to
make
decisions
cases
suspected
food
allergy;
assess
risks
life-threatening
reactions;
optimize
elimination
diet;
identify
cross-reactivity;
diagnose
inhalant
allergies
determine
their
significance;to
provide
optimal
recommendations
reducing
exposure
inhalation
allergens;
rationally
select
pharmacotherapy
allergen-specific
immunotherapy;
predict
course
disease,
including
development
atopic
march.
addition,
foundation
establishing
a
system
preventing
this
article,
we
tried
outline
main
achievements
prospects
application
pediatric
practice.
Journal of Asthma and Allergy,
Год журнала:
2025,
Номер
Volume 18, С. 363 - 375
Опубликована: Март 1, 2025
This
study
aimed
to
investigate
the
molecular
sensitization
patterns
of
cats,
dogs,
and
horses
in
patients
with
cat
and/or
dog
IgE
cross-reactivity
other
furry
animals.
In
95
diagnosed
allergic
diseases
sensitized
cats
dogs
(confirmed
by
specific
Immunoglobulin
E
(sIgE)
≥
0.35
kUA/L
crude
dander
extracts),
sIgE
levels
components
(Fel
d
1/2/4),
(Can
f
1/2/3/5),
horse
(Equ
c
1),
as
well
allergens
from
cow,
guinea
pig,
mouse,
rat,
rabbit,
chicken,
were
measured.
Sensitization
profiles
analyzed.
Inhibition
tests
using
serum
albumin
(SA)
lipocalin
proteins
performed.
rates
extracts
animals
ranged
16.8%
49.5%.
A
strong
positive
correlation
between
2
Can
3)
rabbit
epithelium,
mouse
pig
epithelium
rat
(rs:
0.66-0.87,
all
P
<
0.05),
while
family
4,
1,
Equ
1)
only
had
a
low
moderate
epithelial
above
four
0.36-0.65,
0.05).
Simultaneous
SA
these
animal
accounted
for
42.4%.
significantly
higher
SA-positive
groups
(all
0.05)
The
results
inhibition
test
showed
that
Fel
3
high
allergens,
ranging
66.5%
91.8%
75.8%
91.9%,
respectively.
When
used
inhibitors,
almost
lower
than
50%.
is
primary
driver
cross-sensitization
animals,
rather
lipocalins.
