Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead

Frontiers in Integrative Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 17, 2023

Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band is widely implicated to be involved in a wide range of processes. As such, decreased oscillation has declines neurological diseases, such as memory dysfunction Alzheimer's disease (AD). Recently, studies attempted artificially induce by using 40 Hz sensory entrainment stimulation. These reported attenuation amyloid load, hyper-phosphorylation tau protein, and improvement overall cognition both AD patients mouse models. In this review, we discuss advancements use stimulation animal models therapeutic strategy patients. We also future opportunities, well challenges, for strategies other neurodegenerative neuropsychiatric diseases.

Язык: Английский

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Applications of OPM-MEG for translational neuroscience: a perspective

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 24, 2024

Abstract Magnetoencephalography (MEG) allows the non-invasive measurement of brain activity at millisecond precision combined with localization underlying generators. So far, MEG-systems consisted superconducting quantum interference devices (SQUIDS), which suffer from several limitations. Recent technological advances, however, have enabled development novel based on optically pumped magnetometers (OPMs), offering advantages over conventional SQUID-MEG systems. Considering potential improvements in neuronal signals as well reduced operating costs, application OPM-MEG systems for clinical neuroscience and diagnostic settings is highly promising. Here we provide an overview current state-of-the art its unique translational neuroscience. First, discuss features OPMs benchmark against electroencephalography (EEG), followed by a summary pioneering studies healthy populations. Key applications investigation psychiatric neurological conditions are then reviewed. Specifically, suggest identification biomarkers circuit deficits schizophrenia, dementias, movement disorders, epilepsy, neurodevelopmental syndromes (autism spectrum disorder attention deficit hyperactivity disorder). Finally, give outlook focus remaining methodological technical challenges.

Язык: Английский

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Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia

Schizophrenia Research, Год журнала: 2023, Номер 252, С. 129 - 137

Опубликована: Янв. 13, 2023

Язык: Английский

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Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas

NeuroImage, Год журнала: 2023, Номер 274, С. 120158 - 120158

Опубликована: Май 5, 2023

Magnetoencephalography (MEG) is a widely used non-invasive tool to estimate brain activity with high temporal resolution. However, due the ill-posed nature of MEG source imaging (MSI) problem, ability MSI identify accurately underlying sources along cortical surface still uncertain and requires validation. We validated background resting state 45 healthy participants by comparing it intracranial EEG (iEEG) atlas (https://mni-open-ieegatlas.research.mcgill.ca/). First, we applied wavelet-based Maximum Entropy on Mean (wMEM) as an technique. Next, converted maps into space applying forward model MEG-reconstructed maps, estimated virtual iEEG (ViEEG) potentials each channel location; finally quantitatively compared those actual signals from for 38 regions interest in canonical frequency bands. The spectra were more lateral medial regions. higher amplitude ViEEG than recovered. In deep regions, MEG-estimated amplitudes largely underestimated poorly Overall, our wMEM results similar obtained minimum norm or beamformer localization. Moreover, overestimated oscillatory peaks alpha band, especially anterior This possibly phase synchronization oscillations over extended exceeding spatial sensitivity but detected MEG. Importantly, found that comparable after aperiodic components removed. study identifies frequencies which analysis likely be reliable, promising step towards resolving uncertainty recovering intracerebral studies.

Язык: Английский

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Slowed alpha oscillations and percept formation in psychotic psychopathology

Frontiers in Psychology, Год журнала: 2023, Номер 14

Опубликована: Июнь 14, 2023

Psychosis is in part defined by disturbances perception. Recent investigations have implicated the speed of alpha oscillations observed brain electrical activity as reflective a sampling rate visual environment and Although both slowed aberrant percept formation are evident disorders psychotic psychopathology such schizophrenia it unclear whether slow accounts for abnormal perception these disorders.To examine role we gathered resting-state magneto-encephalography data from probands with (i.e., schizophrenia, schizoaffective disorder, bipolar disorder history psychosis), their biological siblings, healthy controls. We appraised perceptual function without confound cognitive ability effort through use simple binocular rivalry task.We found pace that was associated longer durations during rivalry, consistent assertion occipital govern accumulation information used to generate percepts. Alpha varied widely across individuals highly stable several months indicating likely trait characteristic neural relevant Finally, lower oscillation IQ greater symptomatology implying effects endogenous on may wider consequences everyday functioning.Slowed appear reflect altered functions related formation.

Язык: Английский

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Alpha transcranial alternating current stimulation reduces depressive symptoms in people with schizophrenia and auditory hallucinations: a double-blind, randomized pilot clinical trial

Schizophrenia, Год журнала: 2022, Номер 8(1)

Опубликована: Дек. 24, 2022

People with schizophrenia exhibit reduced alpha oscillations and frontotemporal coordination of brain activity. Alpha are associated top-down inhibition. Reduced may fail to censor spurious endogenous activity, leading auditory hallucinations. Transcranial alternating current stimulation (tACS) at the frequency was shown enhance in people thus be a network-based treatment for We conducted double-blind, randomized, placebo-controlled pilot clinical trial examine efficacy 10-Hz tACS treating hallucinations schizophrenia. administered phase dorsolateral prefrontal cortex temporoparietal junction return Cz. Patients were randomized receive or sham five consecutive days during week (40 min/day), followed by maintenance period, which participants received weekly min/visit) sham. general psychopathology (p < 0.05, Cohen's d = -0.690), especially depression 0.005, -0.806), but not increased power target region 0.05), peak global functional connectivity towards 10 Hz left-right frontal 0.005). Importantly, changes significantly correlated symptom improvement 0.05). Daily Hz-tACS altered alpha-band connectivity. Successful engagement other symptoms, Considering existing research 10Hz as major depressive disorder, our study demonstrates its transdiagnostic potential depression.

Язык: Английский

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Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets

Psychiatry and Clinical Neurosciences, Год журнала: 2022, Номер 76(8), С. 361 - 366

Опубликована: Май 10, 2022

The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared components these based on multipopulation data sets.We used two sets for East Asian (EAS) European (EUR) samples. SCZ was Psychiatric Genomics Consortium Asia with our own genome-wide association study EAS EUR. Nonpsychiatric (20 binary traits [mainly complex disorders] 34 quantitative laboratory examinations physical characteristics]) were obtained from Biobank Japan UK EUR samples, respectively. To evaluate correlation, linkage disequilibrium score regression analysis utilized further meta-analysis each result samples to obtain robust evidence. Subsequent mendelian randomization also included examine causal effect.A significant correlation several metabolic syndrome (MetS) detected in combined (meta-analysis data) (body mass index [rg = -0.10, q-value 1.0 × 10-9 ], high-density-lipoprotein cholesterol 0.072, 2.9 10-3 blood sugar -0.068, 1.4 10-2 triglycerides -0.052, 2.4 systolic pressure -0.054, 3.5 C-reactive protein -0.076, 7.8 10-5 ]. However, no susceptibility analysis.Our results indicate MetS protein. Specifically, we found it interesting that opposite of expected clinical studies: this suggests associated reduced MetS. This implied patients not but environmental factors, including antipsychotics, lifestyle changes, poor diet, lack exercise, living conditions.

Язык: Английский

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$\bm{\xi}$-$\bm{\pi}$: A Nonparametric Model for Neural Power Spectra Decomposition

IEEE Journal of Biomedical and Health Informatics, Год журнала: 2024, Номер 28(5), С. 2624 - 2635

Опубликована: Фев. 9, 2024

The power spectra estimated from the brain recordings are mixed representation of aperiodic transient activity and periodic oscillations, i.e., component (AC) (PC). Quantitative neurophysiology requires precise decomposition preceding parameterizing each component. However, shape, statistical distribution, scale, mixing mechanism AC PCs unclear, challenging effectiveness current popular parametric models such as FOOOF, IRASA, BOSC, etc. Here, $\xi$ - notation="LaTeX">$\pi$ was proposed to decompose neural by embedding nonparametric estimation with penalized Whittle likelihood shape language modeling into expectation maximization framework. validated on synthesized loss statistics sleep EEG large sample iEEG evaluation metrics neurophysiological evidence. Compared both simulation presenting irregularities batch multiple isolated peaks indicated that improved fit less higher F1-score in recognizing centering frequencies number peaks; revealed produced more distinguishable exponents state classification accuracy; showed approached clinical findings peak discovery. Overall, offered good performance decomposition, which allows flexible parameterization using descriptive or kernel functions. is a seminal tool for signal decoding fields cognitive neuroscience, brain-computer interface, neurofeedback, diseases.

Язык: Английский

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Oscillatory traveling waves provide evidence for predictive coding abnormalities in schizophrenia

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Increased cingulo-orbital connectivity is associated with violent behaviours in schizophrenia

Journal of Psychiatric Research, Год журнала: 2022, Номер 147, С. 183 - 189

Опубликована: Янв. 5, 2022

Язык: Английский

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