Bone Targeting Nanoparticles for the Treatment of Osteoporosis

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1363 - 1383

Опубликована: Фев. 1, 2024

Osteoporosis (OP) affects millions of people worldwide, especially postmenopausal women and the elderly. Although current available anti-OP agents can show promise in slowing down bone resorption, most are not specifically delivered to hard tissue, causing significant toxicity. A bone-targeted nanodrug delivery system reduce side effects precisely deliver drug candidates bone. This review focuses on progress nanoparticles OP therapy. We enumerate existing medications, types categorize pairs common bone-targeting functional groups. Finally, we summarize potential use treatment. Ongoing research into development targeted ligands nanocarriers will continue expand possibilities OP-targeted therapies clinical application.

Язык: Английский

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Current progression in application of extracellular vesicles in central nervous system diseases

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 3, 2024

Abstract Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence blood–brain barrier. Specific proteins RNAs in brain-derived extracellular vesicles (EVs) usually reflect corresponding state brain disease, therefore, EVs can be used as diagnostic biomarkers CNS diseases. In addition, engineered fused target cells delivery cargo, demonstrating great potential nanocarrier platform. We review progress markers drug carriers neurological The main areas include visual imaging, biomarker loading therapy different types It is hoped that increased knowledge will facilitate their translation

Язык: Английский

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Exosomes as new generation vehicles for drug delivery systems

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105562 - 105562

Опубликована: Март 11, 2024

Язык: Английский

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Bioinspired cellular membrane-derived vesicles for mRNA delivery

Theranostics, Год журнала: 2024, Номер 14(8), С. 3246 - 3266

Опубликована: Янв. 1, 2024

The rapid advancement of mRNA as vaccines and therapeutic agents in the biomedical field has sparked hope fight against untreatable diseases.Successful clinical application therapeutics largely depends on carriers.Recently, a new exciting focus emerged natural cell-derived vesicles.These nanovesicles offer many functions, including enhanced drug delivery capabilities immune evasion, thereby presenting unique promising platform for effective safe therapeutics.In this study, we summarize characteristics properties biomimetic systems particular, discuss features cellular membrane-derived vesicles (CDVs) combination synthetic with CDVs.

Язык: Английский

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Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies

Cells, Год журнала: 2024, Номер 13(7), С. 606 - 606

Опубликована: Март 30, 2024

In vitro and preclinical in vivo research the last 35 years has clearly highlighted crucial physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes satellite cells/Schwann cells central peripheral nervous system, respectively. Several possible pharmacological targets to various neurodegenerative disorders painful conditions have therefore been successfully identified, including receptors enzymes, mediators neuroinflammation. However, translation these promising data a clinical setting is often hampered by both technical biological difficulties, making it necessary perform experiments on human models diseases. this review we will, therefore, summarize most relevant contribution pathologies their modulation based obtained post-mortem tissues iPSC-derived brain organoids. The possibility an visualization glia reaction neuroinflammation patients will be also discussed.

Язык: Английский

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Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke

Journal of Neuroimmune Pharmacology, Год журнала: 2024, Номер 19(1)

Опубликована: Апрель 22, 2024

Язык: Английский

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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Nano Convergence, Год журнала: 2024, Номер 11(1)

Опубликована: Май 13, 2024

Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.

Язык: Английский

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Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4279 - 4295

Опубликована: Май 1, 2024

Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are type of cell that only found inside the nervous system. These can differentiate into various kinds cells, potentially regenerating or restoring neural networks within areas brain have been destroyed. This review begins by providing introduction existing approaches for ischemic followed examination promise limits associated with utilization NSCs treatment stroke. Subsequently, comprehensive overview was conducted synthesize literature on underlying processes cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy context mechanisms encompass neuroprotection, inflammatory response suppression, endogenous nerve vascular regeneration facilitation. Nevertheless, translation NSC-sEVs is hindered challenges such as inadequate targeting efficacy insufficient content loading. In light these limitations, we compiled advancements utilizing modified treating stroke based methods vesicle modification. conclusion, examining NSC-sEVs-based anticipated be both fundamental applied investigations about

Язык: Английский

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Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress

Epigenetics, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 27, 2025

The effects of chronically stressing male mice can be transmitted across generations by stress-specific changes in their sperm miRNA content, which induce phenotypes offspring. However, how each stress paradigm alters the levels distinct sets miRNAs is not known. We showed previously that exposure to chronic social instability (CSI) results elevated anxiety and reduced sociability specifically female offspring multiple because it reduces miR-34c stressed males unstressed Here, we describe evidence astrocyte-derived exosomes (A-Exos) carrying mediate CSI has this transgenerational effect on sperm. found decreases carried A-Exos prefrontal cortex amygdala, as well blood males. Importantly, are also these tissues F1 offspring, who despite being exposed stress, exhibit transmit same stress-associated traits Furthermore, restoring content CSI-stressed intravenous injection miR-34c-containing restores These findings reveal an unexpected role for maintaining a process when suppressed mediates example epigenetic inheritance.

Язык: Английский

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Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Neurodegenerative diseases (NDs) like Alzheimer’s, Parkinson’s, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability insufficient blood–brain barrier (BBB) permeability. Recently, exosomes—nanoscale vesicles packed with proteins, RNAs, lipids—have emerged as promising agents potential reshape therapeutic approaches these diseases. Unlike drug carriers, they naturally traverse BBB can deliver bioactive molecules affected neural cells. Their molecular cargo influence cell signaling, reduce neuroinflammation, potentially slow neurodegenerative progression. Moreover, exosomes serve non-invasive biomarkers, enabling precise while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded molecules, enhance this capability targeting diseased neurons overcoming barriers. By offering enhanced reduced immunogenicity, an ability bypass physiological limitations, exosome-based present a transformative advantage over existing approaches. This review examines multifaceted role of NDDs, emphasizing their capabilities, intrinsic functions, advanced vehicles.

Язык: Английский

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