Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 101, С. 106259 - 106259
Опубликована: Окт. 9, 2024
Язык: Английский
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1363 - 1383
Опубликована: Фев. 1, 2024
Osteoporosis (OP) affects millions of people worldwide, especially postmenopausal women and the elderly. Although current available anti-OP agents can show promise in slowing down bone resorption, most are not specifically delivered to hard tissue, causing significant toxicity. A bone-targeted nanodrug delivery system reduce side effects precisely deliver drug candidates bone. This review focuses on progress nanoparticles OP therapy. We enumerate existing medications, types categorize pairs common bone-targeting functional groups. Finally, we summarize potential use treatment. Ongoing research into development targeted ligands nanocarriers will continue expand possibilities OP-targeted therapies clinical application.
Язык: Английский
Процитировано
13
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Янв. 3, 2024
Abstract Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence blood–brain barrier. Specific proteins RNAs in brain-derived extracellular vesicles (EVs) usually reflect corresponding state brain disease, therefore, EVs can be used as diagnostic biomarkers CNS diseases. In addition, engineered fused target cells delivery cargo, demonstrating great potential nanocarrier platform. We review progress markers drug carriers neurological The main areas include visual imaging, biomarker loading therapy different types It is hoped that increased knowledge will facilitate their translation
Язык: Английский
Процитировано
10
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Abstract Neurodegenerative diseases (NDs) like Alzheimer’s, Parkinson’s, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability insufficient blood–brain barrier (BBB) permeability. Recently, exosomes—nanoscale vesicles packed with proteins, RNAs, lipids—have emerged as promising agents potential reshape therapeutic approaches these diseases. Unlike drug carriers, they naturally traverse BBB can deliver bioactive molecules affected neural cells. Their molecular cargo influence cell signaling, reduce neuroinflammation, potentially slow neurodegenerative progression. Moreover, exosomes serve non-invasive biomarkers, enabling precise while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded molecules, enhance this capability targeting diseased neurons overcoming barriers. By offering enhanced reduced immunogenicity, an ability bypass physiological limitations, exosome-based present a transformative advantage over existing approaches. This review examines multifaceted role of NDDs, emphasizing their capabilities, intrinsic functions, advanced vehicles.
Язык: Английский
Процитировано
1
Theranostics, Год журнала: 2024, Номер 14(8), С. 3246 - 3266
Опубликована: Янв. 1, 2024
The rapid advancement of mRNA as vaccines and therapeutic agents in the biomedical field has sparked hope fight against untreatable diseases.Successful clinical application therapeutics largely depends on carriers.Recently, a new exciting focus emerged natural cell-derived vesicles.These nanovesicles offer many functions, including enhanced drug delivery capabilities immune evasion, thereby presenting unique promising platform for effective safe therapeutics.In this study, we summarize characteristics properties biomimetic systems particular, discuss features cellular membrane-derived vesicles (CDVs) combination synthetic with CDVs.
Язык: Английский
Процитировано
9
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105562 - 105562
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
7
Cells, Год журнала: 2024, Номер 13(7), С. 606 - 606
Опубликована: Март 30, 2024
In vitro and preclinical in vivo research the last 35 years has clearly highlighted crucial physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes satellite cells/Schwann cells central peripheral nervous system, respectively. Several possible pharmacological targets to various neurodegenerative disorders painful conditions have therefore been successfully identified, including receptors enzymes, mediators neuroinflammation. However, translation these promising data a clinical setting is often hampered by both technical biological difficulties, making it necessary perform experiments on human models diseases. this review we will, therefore, summarize most relevant contribution pathologies their modulation based obtained post-mortem tissues iPSC-derived brain organoids. The possibility an visualization glia reaction neuroinflammation patients will be also discussed.
Язык: Английский
Процитировано
6
Nano Convergence, Год журнала: 2024, Номер 11(1)
Опубликована: Май 13, 2024
Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.
Язык: Английский
Процитировано
6
Journal of Neuroimmune Pharmacology, Год журнала: 2024, Номер 19(1)
Опубликована: Апрель 22, 2024
Язык: Английский
Процитировано
5
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4279 - 4295
Опубликована: Май 1, 2024
Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are type of cell that only found inside the nervous system. These can differentiate into various kinds cells, potentially regenerating or restoring neural networks within areas brain have been destroyed. This review begins by providing introduction existing approaches for ischemic followed examination promise limits associated with utilization NSCs treatment stroke. Subsequently, comprehensive overview was conducted synthesize literature on underlying processes cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy context mechanisms encompass neuroprotection, inflammatory response suppression, endogenous nerve vascular regeneration facilitation. Nevertheless, translation NSC-sEVs is hindered challenges such as inadequate targeting efficacy insufficient content loading. In light these limitations, we compiled advancements utilizing modified treating stroke based methods vesicle modification. conclusion, examining NSC-sEVs-based anticipated be both fundamental applied investigations about
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135826 - 135826
Опубликована: Сен. 23, 2024
Neurodegenerative diseases (NDDs) are increasingly prevalent with global aging, demanding effective treatments. Exosomes, which contain biological macromolecules such as RNA (including miRNAs) and proteins like α-synuclein, tau, amyloid-beta, gaining attention innovative therapeutics. This comprehensive review systematically explores the potential roles of exosomes in NDDs, a particular focus on their role synaptic dysfunction. We present pathophysiology NDDs discuss mechanisms exosome formation, secretion, action. Subsequently, we different types Alzheimer's disease Parkinson's disease, special regulation function. In addition, explore use biomarkers, well challenges opportunities clinical application. provide perspectives future research directions development trends to more understanding guidance for application treatment NDDs. conclusion, rich macromolecules, novel therapeutic strategy, have opened up new possibilities brought hope patients.
Язык: Английский
Процитировано
5