International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144031 - 144031
Опубликована: Май 1, 2025
Язык: Английский
Frontiers in Nutrition, Год журнала: 2025, Номер 11
Опубликована: Янв. 7, 2025
This study aimed to investigate the association between serum calcium levels and periodontitis in a U.S. adult population, using data from National Health Nutrition Examination Survey (NHANES) 2009-2014. Data were analyzed 8,601 participants aged over 30 years, who categorized based on presence or absence of periodontitis. Serum measured standardized NHANES protocols, status was determined through clinical oral examinations. To assess relationship periodontitis, multivariate logistic regression models applied across three adjustment. Additionally, trend tests subgroup analyses conducted explore associations different demographic subgroups. A smoothing curve fitting threshold effect analysis also performed examine potential nonlinear relationships. After adjusting multiple covariates, highest quartile showed an 18% reduced risk compared those lowest (OR = 0.82, 95% CI: 0.71-0.95, p 0.0083; for 0.0057). The remained stable various Smoothing indicated negative correlation though without significant inflection point at 2.48 mmol/L (p 0.094). Elevated appear be associated with lower adults. These findings suggest that adequate intake may play role prevention, providing valuable insight guidance nutritional preventive strategies periodontal health.
Язык: Английский
Процитировано
3
International Journal of Oral Science, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 1, 2024
Abstarct Odontogenic maxillary sinusitis (OMS) is a subtype of (MS). It actually inflammation the sinus that secondary to adjacent infectious dental lesion. Due lack unique clinical features, OMS difficult distinguish from other types rhinosinusitis. Besides, characteristic pathogeny makes it resistant conventional therapies Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists dentists absolutely urgent settle these questions acquire standardized diagnostic regimen for OMS. However, this disease has received little attention been underrepresented by relatively low publication volume quality. Based on systematically reviewed literature practical experiences expert members, our consensus focuses characteristics, symptoms, classification OMS, further put forward decisions as well common complications relative managements. This aims increase optimize decision-making which finally provides evidence-based options management.
Язык: Английский
Процитировано
14
Small Structures, Год журнала: 2024, Номер 5(3)
Опубликована: Фев. 5, 2024
Alveolar bone resorption caused by bacteria‐induced periodontitis remains challenging due to sustained inflammation. Periodontal pathogens like Porphyromonas gingivalis launch the primed signal of NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome in macrophages; consequent overproduction proinflammatory cytokines and reactive oxygen species (ROS) leads tissue destruction. This provides potential targets for a new therapeutic strategy. Herein, multifunctionalized dual‐crosslinked hydrogel pGM/cPL@NI with NLRP3 inhibitor MCC950 loaded is prepared. Driven strategic functionalization gelatin methacryloyl ε ‐poly‐lysine phenylboronic acid catechol, respectively, containing dynamic photo‐crosslinking networks demonstrates superior mechanical strength stimuli‐responsive behavior, as well overwhelmed performance bacteria killing ROS scavenging. Crucially, restores compromised osteogenesis specifically suppressing cytokine cascade triggered activation promoting anti‐inflammatory polarization macrophages. Collectively, presents robust an effective “cocktail therapy” combining antibacterial, antioxidant, inflammation resolution, regenerative functions. The present study reveals underlying mechanism bacterial‐immune‐regeneration extended approach periodontal engineering.
Язык: Английский
Процитировано
11
Nanotoxicology, Год журнала: 2025, Номер unknown, С. 1 - 35
Опубликована: Март 28, 2025
Because of the intricate interactions between bacteria internalization in periodontal cells and chronic inflammatory activation, disorders remain difficult. Furthermore, primary cause adult tooth loss is periodontitis, one most common dental worldwide. The key to preventing periodontitis has been reduce development generation substances that eventually erode tissue surrounding supporting teeth. there are several disadvantages treating with antibiotics administered systemically. A naturally occurring polymer antibacterial anti-inflammatory properties chitosan (CS). CS highly interested disease as a medicine carrier due its actions against anaerobic microorganisms possible properties. Due multifactorial pathophysiology combining antimicrobial medications single drug delivery method preferable administering them separately since it increases therapeutic range when numerous organisms present. As result, CS-based technologies, such gels, micro, nanoparticles (NPs), were created transport drugs pocket over an extended period. This research provides overview existing benefits CSNP on periodontitis. information might be used create substitutes based for infections.
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2024, Номер 41, С. 271 - 292
Опубликована: Июль 24, 2024
Periodontitis is an inflammatory disease caused by bacterial biofilms, which leads to the destruction of periodontal tissue. Current treatments, such as mechanical cleaning and antibiotics, struggle effectively address persistent inflammation, tissue damage. A new approach involves developing a Janus nanomotor (J-CeM@Au) coating cerium dioxide-doped mesoporous silica (CeM) with gold nanoparticles (AuNPs). This exhibits thermophoretic motion when exposed near-infrared (NIR) laser light due temperature gradient produced photothermal effects asymmetrically distributed AuNPs. The NIR provides energy for propulsion activates nanomotor's antibacterial properties, allowing it penetrate biofilms kill bacteria. Additionally, ability scavenge reactive oxygen species (ROS) can modulate immune response create regenerative environment, promoting healing Overall, this multifunctional offers promising treating periodontitis simultaneously addressing biofilm management modulation autonomous movement.
Язык: Английский
Процитировано
9
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33053 - 33069
Опубликована: Июнь 20, 2024
The primary pathology of periodontitis involves the gradual deterioration periodontal tissues resulting from inflammatory reaction triggered by bacterial infection. In this study, a novel drug for pocket injection, known as Shed-Cu-HA hydrogel, was developed incorporating copper ions (Cu2+) and Shed-derived exosomes (Shed-exo) inside hyaluronic acid (HA) hydrogel. Suitable concentrations Cu2+ Shed-exo released enhanced cell viability proliferation human ligament stem cells. Additionally, demonstrated remarkable antibacterial effects against key pathogen (Aa) owing to synergistic effect HA. Furthermore, material effectively suppressed macrophage response via IL-6/JAK2/STAT3 pathway. Moreover, Shed-Cu-HA, combining inflammation-regulating properties HA with osteogenic activity Cu2+, upregulated expression genes proteins associated differentiation. experimental findings mouse model that administration reduced extent infiltration infections in gingival facilitated regeneration bone collagen after 2 4 weeks injection. Consequently, it holds significant prospects future applications treatment.
Язык: Английский
Процитировано
7
International Journal of Dentistry, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Aim: Noncontained (1‐ or combined 1‐ to 2‐wall) periodontal intraosseous defects represent challenging clinical situations with unpredictable surgical therapeutic outcomes. This randomized trial assessed demineralized freeze‐dried bone allograft (DFDBA) low speed‐platelet‐rich fibrin (PRF) membrane compared DFDBA collagen (CM) in the therapy of noncontained stage III periodontitis patients. Methodology: Twenty‐two patients measuring ≥3 mm and attachment loss ≥5 were randomly allocated into two groups: test group (low‐speed PRF + DFDBA) control (CM DFDBA), 11 participants per group. Clinical radiographic assessments conducted at baseline, 3, 6, 9, 12 months for level (CAL; primary outcome), gingival recession depth (GRD), probing (PD), full mouth bleeding score (FMBS) plaque (FMPS), fill linear defect (RLDD; all secondary outcomes). Results: The mean (±SD) CAL‐gain was 2.45 (±1.51), 2.91 (±1.70), (±1.87), 2.82 (±1.83) mm, while (±1.25), 3.27 (±1.27), 3.00 (±1.41), 2.64 (±1.50) months, respectively, no significant intergroup differences ( p > 0.05). Despite absence differences, both groups demonstrated intragroup improvement CAL‐ PD‐gain, RLDD‐reduction as well RLDD < Conclusion: membranes, conjunction DFDBA, show parameters, comparable CMs DFDBA. Trial Registration: ClinicalTrials.gov identifier: NCT03922503
Язык: Английский
Процитировано
1
Periodontology 2000, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Abstract The objective of the study was to compare treatment outcomes periodontal furcation defects by using platelet‐rich fibrin (PRF) with other commonly utilized modalities. eligibility criteria comprised randomized controlled trials (RCTs) comparing clinical PRF those modalities for defects. Studies were classified into 11 categories in 3 different groups as follows: Group I (addition PRF): (1) open flap debridement (OFD) alone versus OFD/PRF, (2) OFD/bone graft (OFD/BG) OFD/BG/PRF; II (comparative studies (3) OFD/BG (4) OFD/collagen membrane (5) OFD/PRP (6) OFD/rhBMP2 OFD/PRF; and III biomaterial/biomolecule OFD/PRF … (7) OFD/PRF/BG, (8) OFD/PRF/amniotic (AM), (9) OFD/PRF/metformin, (10) OFD/PRF/bisphosphonates, (11) OFD/PRF/statins. Weighted means forest plots calculated reduction probing pocket depth (PPD), gain vertical horizontal attachment levels (VCAL HCAL), bone (VBL, HBL), radiographic fill (RBF). From 45 articles identified, 21 RCTs reporting on class furcations included. use OFD/BG/PRF statistically significantly reduced PPD improved VCAL HCAL when compared OFD or OFD/BG, respectively. comparison between OFD/CM, OFD/PRP, led similar all investigated parameters, including a PPD, VCAL/HCAL gain, RBF. additional incorporation BG only mildly outcomes, whereas addition AM outcomes. small biomolecules such metformin, bisphosphonates, statins significant improvements VCAL, alone. Noteworthy, very high heterogeneity found studies. alone, being observed and/or OFD/rhBMP2. Future research geared toward better understanding potential ways enhance regenerative properties various may prove valuable future applications. histological investigating human is largely needed. conjunction values, yielding comparable used biomaterials. combination grafts offer benefits, thus warranting investigation.
Язык: Английский
Процитировано
6
Journal of Periodontal Research, Год журнала: 2024, Номер 59(4), С. 679 - 688
Опубликована: Март 25, 2024
This study aimed to investigate the factors influencing clinical outcomes of regenerative therapy using recombinant human fibroblast growth factor-2 (rhFGF-2).
Язык: Английский
Процитировано
5
Journal of Dental Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 21, 2024
Cementum, a bone-like tissue, is an essential component of periodontium, and periodontitis can lead to degenerative changes in the cementum, eventually resulting tooth loss. The therapeutic strategy for advanced achieve periodontal regeneration, which cementum regeneration key criterion. Cementoblasts are responsible cementogenesis, their mineralization counts regeneration. However, research still limited. Thus, novel treatment targets required. expression levels lysine (K)–specific demethylase 6B (KDM6B), fatty acid oxidation (FAO), cementogenic markers were detected by quantitative polymerase chain reaction, Western blot, immunofluorescence, immunohistochemical assays. FAO analyzed assay kit. In vivo, injection GSK-J4 into mice influence KDM6B on formation. Chromatin immunoprecipitation sequencing, transcriptomic RNA subsequent chromatin immunoprecipitation–quantitative reaction overexpression HADHA (hydroxyacyl-coA dehydrogenase trifunctional multienzyme complex subunit alpha) elucidated KDM6B- Hadha axis. Global lactylation was blot. Lactylation proteomics clarified modified sites HADHA. Mutating these applying coimmunoprecipitation confirmed significance. Knockdown Kdm6b utilized assess its regulation HADHA, FAO, levels. elevated during cementoblast mineralization. targeted activated transcription, thereby increasing promoting occurred process mineralization, could regulate promote Overexpression addition lactate sodium rescue inhibition knockdown Kdm6b. summary, regulates mediating histone demethylation lactylation, upregulating thus
Язык: Английский
Процитировано
4