Russian Physics Journal, Год журнала: 2024, Номер unknown
Опубликована: Сен. 20, 2024
Язык: Английский
Biomimetics, Год журнала: 2024, Номер 9(3), С. 153 - 153
Опубликована: Март 1, 2024
The rehabilitation of alveolar bone defects moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, guided regeneration technique combined with various grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, dimensional stability. Thus, development biomimetic scaffolds tailor-made characteristics that can modulate cell tissue interaction may be a promising tool. This article presents critical consideration in scaffold’s design while also providing information on fabrication methods nanosystems. Their utilization delivery systems will mentioned.
Язык: Английский
Процитировано
11
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(22), С. 6962 - 6962
Опубликована: Ноя. 7, 2023
Guided bone regeneration (GBR) is a promising technique in tissue engineering that aims to replace lost or injured using resorbable scaffolds. The promotion of osteoblast adhesion, migration, and proliferation greatly aided by GBR materials, surface changes are critical imitating the natural structure improve cellular responses. Moreover, interactions between bioresponsive scaffolds, growth factors (GFs), immune cells, stromal progenitor cells essential promoting regeneration. This literature review comprehensively discusses various aspects scaffolds engineering, encompassing scaffold design, fabrication techniques, advanced manufacturing methods, including three-dimensional printing. In addition, this explores modifications replicate native structures their impact on mechanisms described, providing information how GFs, orchestrate healing. Practical applications clinical settings presented underscore importance these principles integration, healing, Furthermore, delves into emerging areas metamaterials artificial intelligence regenerative medicine. These interdisciplinary approaches hold immense promise for furthering improving therapeutic outcomes, leading enhanced patient well-being. potential combining material science, manufacturing, biology showcased as pathway advance addressing variety needs challenges. By comprehensive narrative, detailed, up-to-date account scaffolds' role transformative offered.
Язык: Английский
Процитировано
20
Periodontology 2000, Год журнала: 2023, Номер 94(1), С. 627 - 638
Опубликована: Сен. 28, 2023
The aim of this study was to investigate the biological outcomes bone-level implants restored with long vs. short abutments, regard 'one abutment at one time' protocol. systematic search performed in five databases: MEDLINE (PubMed), EMBASE, Web Science, Scopus, and CENTRAL for randomized controlled trials up January 14, 2023. Data were collected marginal bone loss, bleeding on probing, probing pocket depth by two reviewers. As effect size measure, mean difference (MD), risk ratio (RR) used continuous categorical outcomes, R-statistics software conducting statistical analyses. For quality certainty assessment, Risk Bias Tool 2, ROBINS-I, GRADE approach used. resulted 4055 records without any duplicates. After title, abstract, full-text analysis, eight articles found eligible inclusion. Bone-level platform-switched presented less loss after 6 months 1 year as well, when abutments (MD 0.63, 95% CI: [-0.16; 1.42]) 0.26, [-0.02; 0.53]). However, subgroup analysis revealed no applying protocol (p = 0.973). Bleeding similarly good results both groups almost differences (RR 0.97, [0.76; 1.23]) -0.05, [-1.11; 1.01]). Longer seem be a favorable choice decreasing early irrespective connection timing.
Язык: Английский
Процитировано
10
Clinical Oral Implants Research, Год журнала: 2024, Номер 35(11), С. 1452 - 1466
Опубликована: Авг. 6, 2024
Examine the histomorphometric bone composition, following alveolar ridge preservation techniques and unassisted socket healing.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135338 - 135338
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
4
Clinical Oral Implants Research, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
ABSTRACT Objectives To evaluate the 1‐ to 5‐year outcomes of dental implants placed with tenting screw (TS) technique and compare their clinical efficacy conventional guided bone regeneration (GBR). Methods This retrospective study involved TS or GBR technique. Horizontal volumetric gains were evaluated by reconstructing cone‐beam computed tomography (CBCT) data. Complications, biological parameters, esthetic scores, patients' satisfaction recorded. Results A total 75 in 42 patients (20 defect sites group 22 group) included this study. With a follow‐up, no failed, resulting 100% implant survival rate. After healing periods, demonstrated horizontal 2.85 ± 1.42 mm, 3.37 1.79 3.27 1.68 mm at 1, 3, 5 below shoulder, significantly exceeding ( p = 0.009, 0.002, respectively). Consistently, three‐dimensional resorption rates for groups after periods 16.5% 29.3% < 0.001), increasing 36.7% 50.7% follow‐up 0.001). The overall PPDs smaller than those (2.50 (2.25, 2.50) vs. 2.50 2.75) 0.038). No other significant differences observed terms peri‐implant soft tissue health, esthetics, satisfaction. Conclusions Considering superior augmentation comparable patient technique, emerges as reliable treatment option atrophic alveolar ridges anterior maxilla.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way
Язык: Английский
Процитировано
0
Journal of Clinical Personalized Medicine, Год журнала: 2025, Номер 04(02), С. 1073 - 1084
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2024, Номер 11(30)
Опубликована: Июнь 14, 2024
Abstract Maxillofacial bone defects exhibit intricate anatomy and irregular morphology, presenting challenges for effective treatment. This study aimed to address these by developing an injectable bioactive composite microsphere, termed D‐P‐Ak (polydopamine‐PLGA‐akermanite), designed fit within the defect site while minimizing injury. The microspheres biodegraded gradually, releasing calcium, magnesium, silicon ions, which, notably, not only directly stimulated osteogenic differentiation of marrow mesenchymal stem cells (BMSCs) but also activated sensory nerve secrete calcitonin gene‐related peptide (CGRP), a key factor in repair. Moreover, released CGRP enhanced BMSCs through epigenetic methylation modification. Specifically, inhibition EZH2 enhancement KDM6A reduced trimethylation level histone 3 at lysine 27 (H3K27), thereby activating transcription genes such as Runx2 Osx. efficacy repair is validated rat mandibular model, demonstrating that peripheral response facilitates regeneration These findings illuminated novel strategy constructing neuroactive osteo‐inductive biomaterials with potential further clinical applications.
Язык: Английский
Процитировано
3
Materials, Год журнала: 2024, Номер 17(19), С. 4782 - 4782
Опубликована: Сен. 28, 2024
Bone grafting in oral and maxillofacial surgery has evolved significantly due to developments materials science, offering innovative alternatives for the repair of bone defects. A few grafts are currently used clinical settings, including autografts, xenografts, allografts. However, despite their benefits, they have some challenges, such as limited availability, possibility disease transmission, lack personalization defect. Synthetic gained attention since potential overcome these limitations. Moreover, new technologies like nanotechnology, 3D printing, bioprinting allowed incorporation molecules or substances within aid repair. The addition different moieties, growth factors, stem cells, nanomaterials, been reported help mimic natural healing process more closely, promoting faster complete regeneration. In this regard, review explores available grafts, incorporating into composition accelerate improve regeneration, advanced graft manufacturing techniques. Furthermore, presented current applications success stories novel emphasize future synthetic biomaterial innovations improving patient outcomes surgery.
Язык: Английский
Процитировано
3