Frontiers in Oncology,
Год журнала:
2021,
Номер
11
Опубликована: Дек. 14, 2021
The
aim
of
the
study
was
to
develop
an
algorithm
predict
postoperative
pneumonia
among
elderly
patients
with
lung
cancer
after
video-assisted
thoracoscopic
surgery.
We
analyzed
3,009
from
Thoracic
Perioperative
Database
for
Geriatrics
in
our
hospital
and
finally
enrolled
1,585
(age≧65
years)
treated
included
were
randomly
divided
into
a
training
group
(n
=
793)
validation
792).
Patients
used
screening
up
30
potential
risk
factors,
internally
validate
algorithm.
External
achieved
external
dataset
enrolling
165
surgery
two
hospitals
China.
Of
all
patients,
9.15%
(145/1,585)
suffered
Geriatrics,
10.30%
(17/165)
had
dataset.
consisted
seven
variables,
including
sex,
smoking,
history
chronic
obstructive
pulmonary
disease
(COPD),
duration,
leukocyte
count,
intraoperative
injection
colloid,
hormone.
C-index
receiver
operating
characteristic
curve
(AUROC)
0.70
group,
0.67
internal
0.71
dataset,
corresponding
calibration
slopes
0.88
(95%
confident
interval
[CI]:
0.37-1.39),
0.90
CI:
0.46-1.34),
1.03
0.24-1.83),
respectively.
actual
probabilities
5.14%
(53/1031)
low-risk
15.07%
(71/471)
medium-risk
25.30%
(21/83)
high-risk
(p
<
0.001).
can
be
useful
prognostic
tool
developing
The Annals of Applied Statistics,
Год журнала:
2022,
Номер
16(2)
Опубликована: Июнь 1, 2022
In
the
absence
of
a
randomized
experiment,
key
assumption
for
drawing
causal
inference
about
treatment
effects
is
ignorable
assignment.
Violations
ignorability
may
lead
to
biased
effect
estimates.
Sensitivity
analysis
helps
gauge
how
conclusions
will
be
altered
in
response
potential
magnitude
departure
from
assumption.
However,
sensitivity
approaches
unmeasured
confounding
context
multiple
treatments
and
binary
outcomes
are
scarce.
We
propose
flexible
Monte
Carlo
approach
such
settings.
first
derive
general
form
bias
introduced
by
confounding,
with
emphasis
on
theoretical
properties
uniquely
relevant
treatments.
then
methods
encode
impact
adjust
estimates
which
presumed
removed.
Our
proposed
embed
nested
imputation
within
Bayesian
framework,
allow
seamless
integration
uncertainty
values
parameters
sampling
variability
as
well
use
Additive
Regression
Trees
modeling
flexibility.
Expansive
simulations
validate
our
gain
insight
into
SEER-Medicare
data
demonstrate
using
three
early
stage
nonsmall
cell
lung
cancer.
The
developed
this
work
readily
available
R
package
SAMTx.
Medicine,
Год журнала:
2024,
Номер
103(6), С. e36929 - e36929
Опубликована: Фев. 9, 2024
Investigating
the
applying
effects
of
enhanced
recovery
after
surgery
(ERAS)
in
perioperative
period
elderly
lung
cancer
patients
undergoing
surgery.
We
randomly
selected
98
with
who
were
admitted
to
our
hospital
and
underwent
from
January
2022
September
2023
as
study
subjects.
The
control
group
received
conventional
care
during
period,
intervention
ERAS-guided
measures.
differences
perioperative-related
indices,
pulmonary
function,
pain
level,
inflammatory
factors,
postoperative
complication
rates
between
these
2
groups
compared.
extubation
time,
activity
time
since
getting
out
bad
stay
lower
observation
than
those
(P
<
.05).
At
3
days
postoperatively,
FEV1,
forced
vital
capacity
maximum
ventilation
volume
their
same
before
surgery,
higher
numerical
rating
scale
both
at
6
hours
was
that
tumor
necrosis
factor-α,
IL-6,
CRP
incidence
complications
ERAS
applied
can
shorten
stay,
promote
on
alleviate
inflammation,
reduce
risk
complications.
Abstract
Background
The
optimal
modality
for
postoperative
analgesia
after
uniportal
video-assisted
thoracoscopic
surgery
(UVATS)
the
treatment
of
lung
cancer
has
not
yet
been
determined.
Both
ultrasound-guided
paravertebral
block
(PVB)
and
retrolaminar
(RLB)
have
reported
to
be
successful
in
providing
UVATS.
However,
which
technique
provides
superior
UVATS
is
still
unclear.
This
randomized
study
was
designed
compare
analgesic
effects
adverse
events
associated
with
PVB
RLB
Methods
Sixty
patients
were
undergo
(group
P)
or
R).
In
group
P,
30
mL
0.5%
ropivacaine
injected
at
T3
T5
levels
via
(15
each
level
on
operative
side).
R,
primary
outcome
numerical
rating
scale
(NRS)
score
within
48
h
surgery.
secondary
outcomes
total
sufentanil
consumption,
time
first
request
events.
Results
At
3,
6,
12,
24,
36
postoperatively,
NRS
rest
P
lower
than
that
R
(
p
<
0.05).
24
while
coughing
consumption
significantly
0.001).
Additionally,
longer
0.0001).
incidence
nausea
higher
Conclusions
undergoing
UVATS,
better
results
less
RLB.
Compared
RLB,
seems
a
Trial
registration
name
this
Effect
And
Mechanism
Of
Ultrasound-guided
Multimodal
Regional
Nerve
Block
On
Acute
Chronic
Pain
After
Thoracic
Surgery.
registered
Chinese
Clinical
Registry
ChiCTR2100044060
).
date
March
9,
2021.
Frontiers in Oncology,
Год журнала:
2021,
Номер
11
Опубликована: Дек. 14, 2021
The
aim
of
the
study
was
to
develop
an
algorithm
predict
postoperative
pneumonia
among
elderly
patients
with
lung
cancer
after
video-assisted
thoracoscopic
surgery.
We
analyzed
3,009
from
Thoracic
Perioperative
Database
for
Geriatrics
in
our
hospital
and
finally
enrolled
1,585
(age≧65
years)
treated
included
were
randomly
divided
into
a
training
group
(n
=
793)
validation
792).
Patients
used
screening
up
30
potential
risk
factors,
internally
validate
algorithm.
External
achieved
external
dataset
enrolling
165
surgery
two
hospitals
China.
Of
all
patients,
9.15%
(145/1,585)
suffered
Geriatrics,
10.30%
(17/165)
had
dataset.
consisted
seven
variables,
including
sex,
smoking,
history
chronic
obstructive
pulmonary
disease
(COPD),
duration,
leukocyte
count,
intraoperative
injection
colloid,
hormone.
C-index
receiver
operating
characteristic
curve
(AUROC)
0.70
group,
0.67
internal
0.71
dataset,
corresponding
calibration
slopes
0.88
(95%
confident
interval
[CI]:
0.37-1.39),
0.90
CI:
0.46-1.34),
1.03
0.24-1.83),
respectively.
actual
probabilities
5.14%
(53/1031)
low-risk
15.07%
(71/471)
medium-risk
25.30%
(21/83)
high-risk
(p
<
0.001).
can
be
useful
prognostic
tool
developing
