The most common skin symptoms in young adults and adults related to SARS-CoV-2 virus infection

Archives of Dermatological Research, Год журнала: 2024, Номер 316(6)

Опубликована: Май 31, 2024

Abstract Scientists from various areas of the world indicate in their studies that skin lesions occur course infection with SARS-CoV-2 virus. This article is a review most frequently described cutaneous manifestations virus and potential pathophysiology development, as well information on abnormalities histopathological tests. The describes impact some factors related to COVID-19 pandemic exacerbation chronic dermatological diseases. work was constructed basis 142 research studies, reviews, meta-analyses, focusing methods materials used individual works results conclusions resulting them. Some may be prognostic marker disease also prodromal symptom or only infection. Stress exacerbate A correlation observed between type patient’s age. occurrence diseases influenced by drugs treat infections caused SARS-CoV-2. relationship ethnic origin occurring COVID-19. There need further diagnose learn detailed pathomechanism order better understand essence find an appropriate treatment method.

Язык: Английский

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Oncofertility and Fertility Preservation for Women with Gynecological Malignancies: Where Do We Stand Today?

Biomolecules, Год журнала: 2024, Номер 14(8), С. 943 - 943

Опубликована: Авг. 3, 2024

Oncofertility is a growing medical and research field that includes two main areas: oncology reproductive medicine. Nowadays, the percentage of patients surviving cancer has exponentially increased, leading to need for intervention fertility preservation in both men women. Specifically, gynecological malignancies women pose an additional layer complexity due organs being affected. In present review, we report options with cancer- stage-specific focus. We explore drawbacks necessity planning applications during emergency statuses (i.e., COVID-19 pandemic) comment on importance repro-counseling multifaceted their oncological journey.

Язык: Английский

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Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition

Frontiers in Molecular Biosciences, Год журнала: 2022, Номер 9

Опубликована: Сен. 26, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which, since in China, has rapidly become a worldwide pandemic. The aggressiveness and global spread were enhanced by the many SARS-CoV-2 variants that have been isolated up to now. These mutations affect mostly viral glycoprotein Spike (S), capsid protein mainly involved early stages of entry processes, through recognition specific receptors on host cell surface. In particular, subunit S1 contains Receptor Binding Domain (RBD) it is responsible for interaction with angiotensin-converting enzyme (ACE2). Although ACE2 primary receptor currently studied, demonstrated also able infect cells expressing low levels ACE2, indicating virus may alternative cells. identification can better elucidate pathogenicity tropism SARS-CoV-2. Therefore, we investigated interactomes, starting from membrane proteins non-pulmonary lines, such as human kidney (HK-2), normal colon (NCM460D), colorectal adenocarcinoma (Caco-2). We employed an affinity purification-mass spectrometry (AP-MS) pull down, extracts all partners recombinant form domain. purified interactors identified shotgun proteomics approach. lists potential interacting then clusterized according cellular localization, biological pathways, highlighting new possible intracellular functions, crucial not only entrance mechanisms but replication propagation processes.

Язык: Английский

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Conjunctival epithelial cells resist productive SARS-CoV-2 infection

Stem Cell Reports, Год журнала: 2022, Номер 17(7), С. 1699 - 1713

Опубликована: Июнь 23, 2022

Conjunctival epithelial cells, which express viral-entry receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine type (TMPRSS2), constitute the largest exposed epithelium of ocular surface tissue may represent a relevant route. To address this question, we generated an organotypic air-liquid-interface model conjunctival epithelium, composed basal, suprabasal, superficial fibroblasts, could be maintained successfully up to day 75 differentiation. Using single-cell RNA sequencing (RNA-seq), with complementary imaging virological assays, observed that while all cell types were permissive severe acute respiratory syndrome coronavirus (SARS-CoV-2) genome expression, productive infection did not ensue. The early innate immune response SARS-CoV-2 in cells was characterised by robust autocrine paracrine NF-κB activity, without activation antiviral interferon signalling. Collectively, these data enrich our understanding at human surface, potential implications for design preventive strategies transplantation.

Язык: Английский

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The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

Biomolecules, Год журнала: 2023, Номер 13(5), С. 803 - 803

Опубликована: Май 9, 2023

The triamine spermidine is a key metabolite of the polyamine pathway. It plays crucial role in many infectious diseases caused by viral or parasitic infections. Spermidine and its metabolizing enzymes, i.e., spermidine/spermine-N1-acetyltransferase, spermine oxidase, acetyl deoxyhypusine synthase, fulfill common functions during infection protozoa viruses which are obligate, intracellular parasites. competition for this important between infected host cell pathogen determines severity disabling human parasites pathogenic viruses. Here, we review impact metabolites disease development most important, such as SARS-CoV-2, HIV, Ebola, Plasmodium Trypanosomes. Moreover, state-of-the-art translational approaches to manipulate metabolism discussed accelerate drug against these threatful, diseases.

Язык: Английский

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