European Journal of Clinical Investigation,
Год журнала:
2020,
Номер
50(10)
Опубликована: Июль 29, 2020
Identification
of
reliable
outcome
predictors
in
coronavirus
disease
2019
(COVID-19)
is
paramount
importance
for
improving
patient's
management.A
systematic
review
literature
was
conducted
until
24
April
2020.
From
6843
articles,
49
studies
were
selected
a
pooled
assessment;
cumulative
statistics
age
and
sex
retrieved
587
790
602
234
cases.
Two
endpoints
defined:
(a)
composite
including
death,
severe
presentation,
hospitalization
the
intensive
care
unit
(ICU)
and/or
mechanical
ventilation;
(b)
in-hospital
mortality.
We
extracted
numeric
data
on
patients'
characteristics
cases
with
adverse
outcomes
employed
inverse
variance
random-effects
models
to
derive
estimates.We
identified
18
12
factors
associated
endpoint
respectively.
Among
those,
history
CVD
(odds
ratio
(OR)
=
3.15,
95%
confidence
intervals
(CIs)
2.26-4.41),
acute
cardiac
(OR
10.58,
5.00-22.40)
or
kidney
5.13,
1.78-14.83)
injury,
increased
procalcitonin
4.8,
2.034-11.31)
D-dimer
3.7,
1.74-7.89),
thrombocytopenia
6.23,
1.031-37.67)
conveyed
highest
odds
endpoint.
Advanced
age,
male
sex,
cardiovascular
comorbidities,
lymphocytopenia
conferred
an
risk
death.
With
respect
treatment
phase,
therapy
steroids
3.61,
CI
1.934-6.73),
but
not
mortality.Advanced
abnormal
inflammatory
organ
injury
circulating
biomarkers
captured
patients
clinical
outcome.
Clinical
laboratory
profile
may
then
help
identify
higher
Journal of Translational Medicine,
Год журнала:
2020,
Номер
18(1)
Опубликована: Июнь 8, 2020
On
December
12th
2019,
a
new
coronavirus
(SARS-Cov2)
emerged
in
Wuhan,
China,
sparking
pandemic
of
acute
respiratory
syndrome
humans
(COVID-19).
the
24th
April
2020,
number
COVID-19
deaths
world,
according
to
COVID-Case
Tracker
by
Johns
Hopkins
University,
was
195,313,
and
confirmed
cases
2,783,512.
The
represents
massive
impact
on
human
health,
causing
sudden
lifestyle
changes,
through
social
distancing
isolation
at
home,
with
economic
consequences.
Optimizing
public
health
during
this
requires
not
only
knowledge
from
medical
biological
sciences,
but
also
all
sciences
related
lifestyle,
behavioural
studies,
including
dietary
habits
lifestyle.Our
study
aimed
investigate
immediate
eating
changes
among
Italian
population
aged
≥
12
years.
comprised
structured
questionnaire
packet
that
inquired
demographic
information
(age,
gender,
place
residence,
current
employment);
anthropometric
data
(reported
weight
height);
(adherence
Mediterranean
diet,
daily
intake
certain
foods,
food
frequency,
meals/day);
(grocery
shopping,
habit
smoking,
sleep
quality
physical
activity).
survey
conducted
5th
2020.A
total
3533
respondents
have
been
included
study,
between
86
years
(76.1%
females).
perception
gain
observed
48.6%
population;
3.3%
smokers
decided
quit
smoking;
slight
increased
activity
has
reported,
especially
for
bodyweight
training,
38.3%
respondents;
group
18-30
resulted
having
higher
adherence
diet
when
compared
younger
elderly
(p
<
0.001;
p
0.001,
respectively);
15%
turned
farmers
or
organic,
purchasing
fruits
vegetables,
North
Center
Italy,
where
BMI
values
were
lower.In
we
provided
first
time
Diet
pattern
lockdown.
However,
as
is
ongoing,
our
need
be
investigated
future
more
extensive
studies.
Clinical Microbiology Reviews,
Год журнала:
2020,
Номер
33(4)
Опубликована: Июнь 23, 2020
In
recent
decades,
several
new
diseases
have
emerged
in
different
geographical
areas,
with
pathogens
including
Ebola
virus,
Zika
Nipah
and
coronaviruses
(CoVs).
Recently,
a
type
of
viral
infection
Wuhan
City,
China,
initial
genomic
sequencing
data
this
virus
do
not
match
previously
sequenced
CoVs,
suggesting
novel
CoV
strain
(2019-nCoV),
which
has
now
been
termed
severe
acute
respiratory
syndrome
CoV-2
(SARS-CoV-2).
Although
coronavirus
disease
2019
(COVID-19)
is
suspected
to
originate
from
an
animal
host
(zoonotic
origin)
followed
by
human-to-human
transmission,
the
possibility
other
routes
should
be
ruled
out.
European Radiology,
Год журнала:
2021,
Номер
31(8), С. 6096 - 6104
Опубликована: Фев. 24, 2021
Abstract
Objective
The
outbreak
of
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-COV-2)
has
caused
more
than
26
million
cases
Corona
virus
disease
(COVID-19)
in
the
world
so
far.
To
control
spread
disease,
screening
large
numbers
suspected
for
appropriate
quarantine
and
treatment
are
a
priority.
Pathogenic
laboratory
testing
is
typically
gold
standard,
but
it
bears
burden
significant
false
negativity,
adding
to
urgent
need
alternative
diagnostic
methods
combat
disease.
Based
on
COVID-19
radiographic
changes
CT
images,
this
study
hypothesized
that
artificial
intelligence
might
be
able
extract
specific
graphical
features
provide
clinical
diagnosis
ahead
pathogenic
test,
thus
saving
critical
time
control.
Methods
We
collected
1065
images
pathogen-confirmed
along
with
those
previously
diagnosed
typical
viral
pneumonia.
modified
inception
transfer-learning
model
establish
algorithm,
followed
by
internal
external
validation.
Results
validation
achieved
total
accuracy
89.5%
specificity
0.88
sensitivity
0.87.
dataset
showed
79.3%
0.83
0.67.
In
addition,
54
first
two
nucleic
acid
test
results
were
negative,
46
predicted
as
positive
an
85.2%.
Conclusion
These
demonstrate
proof-of-principle
using
radiological
timely
accurate
diagnosis.
Key
Points
•
evaluated
performance
deep
learning
algorithm
screen
during
influenza
season.
As
method,
our
relatively
high
image
datasets.
was
used
distinguish
between
other
pneumonia,
both
which
have
quite
similar
radiologic
characteristics.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2020,
Номер
unknown
Опубликована: Фев. 17, 2020
Abstract
Background
The
outbreak
of
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-COV-2)
has
caused
more
than
2.5
million
cases
Corona
Virus
Disease
(COVID-19)
in
the
world
so
far,
with
that
number
continuing
to
grow.
To
control
spread
disease,
screening
large
numbers
suspected
for
appropriate
quarantine
and
treatment
is
a
priority.
Pathogenic
laboratory
testing
gold
standard
but
time-consuming
significant
false
negative
results.
Therefore,
alternative
diagnostic
methods
are
urgently
needed
combat
disease.
Based
on
COVID-19
radiographical
changes
CT
images,
we
hypothesized
Artificial
Intelligence’s
deep
learning
might
be
able
extract
COVID-19’s
specific
graphical
features
provide
clinical
diagnosis
ahead
pathogenic
test,
thus
saving
critical
time
disease
control.
Methods
Findings
We
collected
1,065
images
pathogen-confirmed
(325
images)
along
those
previously
diagnosed
typical
viral
pneumonia
(740
images).
modified
Inception
transfer-learning
model
establish
algorithm,
followed
by
internal
external
validation.
validation
achieved
total
accuracy
89.5%
specificity
0.88
sensitivity
0.87.
dataset
showed
79.3%
0.83
0.67.
In
addition,
54
first
two
nucleic
acid
test
results
were
negative,
46
predicted
as
positive
85.2%.
Conclusion
These
demonstrate
proof-of-principle
using
artificial
intelligence
radiological
timely
accurate
diagnosis.
Author
summary
COVID-19,
measures
time.
pneumonia.
algorithm.
Our
study
represents
apply
effectively
COVID-19.
International Journal of Biological Sciences,
Год журнала:
2020,
Номер
16(10), С. 1753 - 1766
Опубликована: Янв. 1, 2020
The
outbreak
of
Coronavirus
disease
2019
,
caused
by
severe
acute
respiratory
syndrome
(SARS)
coronavirus
2
(SARS-CoV-2),
has
thus
far
killed
over
3,000
people
and
infected
80,000
in
China
elsewhere
the
world,
resulting
catastrophe
for
humans.Similar
to
its
homologous
virus,
SARS-CoV,
which
SARS
thousands
2003,
SARS-CoV-2
might
also
be
transmitted
from
bats
causes
similar
symptoms
through
a
mechanism.However,
COVID-19
lower
severity
mortality
than
but
is
much
more
transmissive
affects
elderly
individuals
youth
men
women.In
response
rapidly
increasing
number
publications
on
emerging
disease,
this
article
attempts
provide
timely
comprehensive
review
swiftly
developing
research
subject.We
will
cover
basics
about
epidemiology,
etiology,
virology,
diagnosis,
treatment,
prognosis,
prevention
disease.Although
many
questions
still
require
answers,
we
hope
that
helps
understanding
eradication
threatening
disease.
Journal of Medical Internet Research,
Год журнала:
2020,
Номер
22(4), С. e19016 - e19016
Опубликована: Апрель 9, 2020
The
recent
coronavirus
disease
(COVID-19)
pandemic
is
taking
a
toll
on
the
world's
health
care
infrastructure
as
well
social,
economic,
and
psychological
well-being
of
humanity.
Individuals,
organizations,
governments
are
using
social
media
to
communicate
with
each
other
number
issues
relating
COVID-19
pandemic.
Not
much
known
about
topics
being
shared
platforms
COVID-19.
Analyzing
such
information
can
help
policy
makers
organizations
assess
needs
their
stakeholders
address
them
appropriately.This
study
aims
identify
main
posted
by
Twitter
users
related
pandemic.Leveraging
set
tools
(Twitter's
search
application
programming
interface
(API),
Tweepy
Python
library,
PostgreSQL
database)
predefined
terms
("corona,"
"2019-nCov,"
"COVID-19"),
we
extracted
text
metadata
(number
likes
retweets,
user
profile
including
followers)
public
English
language
tweets
from
February
2,
2020,
March
15,
2020.
We
analyzed
collected
word
frequencies
single
(unigrams)
double
words
(bigrams).
leveraged
latent
Dirichlet
allocation
for
topic
modeling
discussed
in
tweets.
also
performed
sentiment
analysis
mean
likes,
followers
calculated
interaction
rate
per
topic.Out
approximately
2.8
million
included,
167,073
unique
160,829
met
inclusion
criteria.
Our
identified
12
topics,
which
were
grouped
into
four
themes:
origin
virus;
its
sources;
impact
people,
countries,
economy;
ways
mitigating
risk
infection.
was
positive
10
negative
2
(deaths
caused
increased
racism).
tweet
account
ranged
2722
(increased
racism)
13,413
(economic
losses).
highest
15.4
loss),
while
lowest
3.94
(travel
bans
warnings).Public
crisis
response
activities
ground
online
becoming
increasingly
simultaneous
intertwined.
Social
provides
an
opportunity
directly
public.
Health
systems
should
work
building
national
international
detection
surveillance
through
monitoring
media.
There
need
more
proactive
agile
presence
combat
spread
fake
news.