Cognitive Function, Sleep, and Neuroinflammatory Markers in Mice Exposed to Very Long-Term Intermittent Hypoxia

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1815 - 1815

Опубликована: Фев. 20, 2025

Chronic intermittent hypoxia (IH) is one of the hallmark features obstructive sleep apnea (OSA) and adversely affects neurocognitive behavioral functioning. However, how duration IH correlates with its deleterious effects remains unexplored. We aimed to assess over a prolonged period time mimicking untreated OSA. Male C57Bl/6J mice were exposed for 96 weeks. Sleep activity was acquired using piezoelectric system. Novel object recognition (NOR) elevated plus maze test (EPMT) conducted as measures cognitive function anxiety, respectively. Brain inflammation evaluated by panel marker assays. All tests performed after 16 weeks exposure. After weeks, percentages during dark phase decreased in both room air (RA) compared 16-week exposure (RA: p = 0.0214; IH: 0.0188). In addition age-dependent declines NOR performance, had lower preference scores than RA controls (p 0.0070). The spent open arms EPMT reduced RA. Inflammatory expression increased IH-exposed mice. Thus, aging induce similar alterations sleep, cognition, neuroinflammation. are exacerbated concurrent IH, suggesting that OSA disease associated an acceleration biological aging.

Язык: Английский

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Impact of exercise training in a hypobaric/normobaric hypoxic environment on body composition and glycolipid metabolism in individuals with overweight or obesity: a systematic review and meta-analysis

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 10, 2025

Objective This study aims to assess the impact of hypoxia training on body composition and glycolipid metabolism in excess weight or living with obese people through meta-analysis. Methods Randomized controlled trials investigating effects composition, glucose, lipid were systematically searched from databases including CNKI, PubMed, Web Science. The meta-analysis was performed by using Stata 18 RevMan 5.4 analytic tools. risk bias assessed Cochrane evaluation tool, level certainty evidence determined GRADE framework. Between-study heterogeneity examined I 2 test, publication evaluated via Egger test funnel plot. Results A total 32 RCTs 1,011 participants included. 25 (499 men 480 women, Age: 40.25 ± 15.69, BMI: 30.96 3.65). In terms outcome indexes fat ratio (MD is −1.16, 95% CI -1.76 −0.56, P = 0.00) group better than normal oxygen group. There no significant difference mass BMI between normal-oxygen ( > 0.05). glucose metabolism, changes found normoxia Subgroup analysis showed that hypoxic environment at altitude 2001–2,500 m could effectively improve mass, TG LDL-C < effective program reduce carry out moderate intensity 45–60 min for ≤8 weeks, ≥4 times a week Conclusion Hypoxic essential reducing people. It recommended moderate-intensity aerobic exercise week, 2,001–2,500 lose mass. are same. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024628550

Язык: Английский

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Nocturnal pulse oxygen saturation dynamics at simulated high altitude: Predictive value for acute mountain sickness in healthy men born pre‐term

Experimental Physiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

The physiological sequelae of pre-term birth might influence the responses this population to hypoxia. Moreover, identifying variables associated with development acute mountain sickness (AMS) remains a key practically significant area altitude research. We investigated effects on nocturnal oxygen saturation ( SpO2${{S}_{{\mathrm{p}}{{{\mathrm{O}}}_{\mathrm{2}}}}}$ ) dynamics and assessed predictive potential -related metrics for morning AMS in 12 healthy adults gestational age < 32 weeks (pre-term) term-born control participants. Participants spent one night at simulated ∼4200 m (normobaric hypoxia; fraction inspired O2 = 0.141), heart rate recorded continuously fingertip using pulse oximetry Lake Louise scale. Pre-term participants had similar mean (mean ± SD; 77% 3% vs. 4%; P 0.661), minimum (median[IQR]; 67[4]% 69[5]%; 0.223), relative time 80% (72% 29% 70% 27%; 0.879) (79 71 7 beats/min; 0.053). However, increase between two halves was blunted prematurity (-0.12% 1.51% 1.11% 0.78%; 0.021). cumulative desaturation-based hypoxic 'load' higher (32[26]%min/h 7[25]%min/h; 0.039), underpinned by increased desaturation frequency (69[49] 21[35] counts/h; 0.009). Mean , predicted incidence better than random classifier exclusively group, no other groups separately or combined. Overall, alter prediction severe

Язык: Английский

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Pulsed Hyperoxia Acts on Plasmatic Advanced Glycation End Products and Advanced Oxidation Protein Products and Modulates Mitochondrial Biogenesis in Human Peripheral Blood Mononuclear Cells: A Pilot Study on the “Normobaric Oxygen Paradox”

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2394 - 2394

Опубликована: Фев. 18, 2024

The “normobaric oxygen paradox” (NOP) describes the response to return normoxia after a hyperoxic event, sensed by tissues as an shortage, up-regulating redox-sensitive transcription factors. We have previously characterized time trend of oxygen-sensitive factors in human PBMCs, which 30% is hypoxic trigger, hypoxia-induced factor (HIF-1) activation. On contrary, 100% and 140% induce shift toward oxidative stress response, NRF2 NF-kB activation first 24 h post exposure. Herein, we investigate whether this paradigm triggers Advanced Glycation End products (AGEs) Oxidation Protein Products (AOPPs) circulating biomarkers stress. Secondly, studied if mitochondrial biogenesis was involved link cellular PBMCs. Our results show that AGEs AOPPs increase different manner according dose. Mitochondrial levels peroxiredoxin (PRX3) supported increased at mild hyperoxia, MH (30% O2), high HH (100% while during very VHH (140% significantly only 3 activated through nuclear translocation PGC-1α all experimental conditions. However, consequent release Transcription Factor A (TFAM) observed Conversely, are associated with progressive loss NOP ability TFAM expression despite also occurring these This study confirms pulsed treatment elicits specific responses, its partial pressure administration, further emphasizes importance targeting use activate effects on whole organism.

Язык: Английский

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Hypoxia Sensing and Responses in Parkinson’s Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1759 - 1759

Опубликована: Фев. 1, 2024

Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions oxygen availability (hypoxia). Here we summarize the evidence pointing a central role of hypoxia PD, discuss relation dependence pathological hallmarks including mitochondrial dysfunction, dopaminergic vulnerability, alpha-synuclein-related pathology, highlight link cellular systemic sensing. We describe cases suggesting that may trigger Parkinsonian symptoms but also emphasize endogenous systems protect from can be harnessed PD. Finally, provide examples preclinical clinical research substantiating this potential.

Язык: Английский

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Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects

Redox Biology, Год журнала: 2024, Номер 72, С. 103152 - 103152

Опубликована: Апрель 5, 2024

Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that sensitive applied radiofrequency (RF) and weak fields (WEMFs), known as pair mechanism (RPM). As a leading model, the RPM explains how quantum can influence biochemical cellular signalling. Consequently, generate reactive oxygen species (ROS) link redox processes, such response hypoxia circadian clock. Therapeutic nuclear resonance (tNMR) occupies unique position in paradigm because used frequencies, which far below range 0.1-100 MHz postulated for occur. Nonetheless, tNMR was shown induce like effects, increased extracellular H2O2 levels altered bioenergetics. In this study we compared impact intermittent clock, well role superoxide induced ROS partitioning. We show both, hypoxia, exert on/off clocks dependent time application (day versus night). addition, our data provide further evidence plays central signal transduction. combination with scavengers, Vitamin C, led strong product redistributions. This discovery might represent first indication triads biological systems.

Язык: Английский

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Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint

Neuroprotection/Neuroprotection (Chichester, England. Print), Год журнала: 2024, Номер 2(3), С. 228 - 242

Опубликована: Июнь 4, 2024

Abstract Hypoxia is more and perceived as pivotal physiological driving force, allowing cells in the brain elsewhere to acclimate lowered oxygen (O 2 ), abridged metabolism. The mediating transcription program induced by inspiratory hypoxia but also intensive motor‐cognitive tasks, provoking a relative decrease O relation acutely augmented requirement. We termed this fundamental, demand‐dependent drop availability “functional hypoxia.” Major players response are hypoxia‐inducible factors (HIFs) associated prolyl‐hydroxylases. HIFs factors, stabilized low accessibility, control expression of multitude genes. Changes oxygen, however, can be sensed via other pathways, among them thiol‐oxidase (2‐aminoethanethiol) dioxygenase. Considering far‐reaching biological hypoxia, hitherto mostly observed rodents, we initiated translational project, combining mild moderate with functional hypoxia. had identified combination earlier benefit attainment mice. A total 20 subjects were included: 13 healthy individuals 7 patients depression and/or autism spectrum disorder. Here, show that training under (12% ) for 3.5 h daily over 3 weeks optimally tolerated. present first signals beneficial effects on general well‐being, cognitive performance, physical fitness psychopathology. Erythropoietin serum increases flow cytometry analysis blood reveals several immune cell types mildly modulated To obtain reliable information regarding “add‐on” value top training, single‐blind study—with versus without hypoxia—is essential outlined here.

Язык: Английский

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Prevalence of occupational hypersensitivity pneumonitis: a systematic review and meta-analysis

International Journal of Environmental Health Research, Год журнала: 2024, Номер unknown, С. 1 - 18

Опубликована: Март 27, 2024

In this meta-analysis, we aimed to evaluate the prevalence of occupational hypersensitivity pneumonitis (OHP) among different occupations globally. Our search was conducted on MEDLINE via PubMed, Scopus, Web Science, and Cochrane CENTRAL from inception September 2023. Eligible studies were observational in nature focused several specific occupations. A total 46 articles included (n = 2,826,420 participants). The overall OHP found be 4.2% (95% CI: 2.1% 8.0%), but varied significantly based occupation geographic location. Printers had highest at 57.14%, followed by tobacco workers (26.32%), water-related (24.10%). South America showed 16.71%, compared Asia (15.19%), North (8.52%). Significant variations region found, with rates printers workers. Age smoking identified as contributing factors variability.

Язык: Английский

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Hypoxia Pathways in Parkinson’s Disease: From Pathogenesis to Therapeutic Targets

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10484 - 10484

Опубликована: Сен. 29, 2024

The human brain is highly dependent on oxygen, utilizing approximately 20% of the body’s oxygen at rest. Oxygen deprivation to can lead loss consciousness within seconds and death minutes. Recent studies have identified regions with spontaneous episodic hypoxia, referred as “hypoxic pockets”. Hypoxia also result from impaired blood flow due conditions such heart disease, clots, stroke, or hemorrhage, well reduced intake excessive consumption caused by factors like low ambient pulmonary diseases, infections, inflammation, cancer. Severe hypoxia in manifest symptoms similar Parkinson’s disease (PD), including cerebral edema, mood disturbances, cognitive impairments. Additionally, development PD appears be closely associated hypoxic pathways. This review seeks investigate molecular interactions between PD, emphasizing pathological role pathways exploring their potential therapeutic targets.

Язык: Английский

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Individualized Algorithm-Based Intermittent Hypoxia Improves Quality of Life in Patients Suffering from Long-Term Sequelae After COVID-19 Infection

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(5), С. 1590 - 1590

Опубликована: Фев. 26, 2025

Background/Objectives: Post-COVID-19 condition (PCC), also known as long COVID, has emerged a recognized syndrome affecting millions of people worldwide, significantly impairing their quality life. Currently, no effective therapeutic options are available to manage this condition. The objective the present study was evaluate long-term effects personalized, algorithm-based intermittent hypoxia–hyperoxia conditioning (IHHC) on life and pain in patients with PCC. Methods: This open-label cohort included 199 PCC patients, aged 11–87 years (female-to-male ratio: 67:33) experiencing moderate-to-severe fatigue, between 1 January 2020 31 December 2023. Each patient received an treatment plan tailored demographics, symptom duration, baseline (NRS) (SF-36) scores. Patients average six sessions (range: 2–21), each consisting hypoxic–hyperoxic cycles, hypoxia (9–13% O2) lasting 3–8 min hyperoxia (34–36% 1–3 min. primary outcomes were changes NRS SF-36 scores at 6-week 6-month follow-ups. Results: At follow-up after initiation, increased by 102 points (p < 0.001, 95% CI: 78.4–127), improvement persisted (Δ106, p 57.0–154). Pain reduced 28–32% both time points, exceeding clinically relevant threshold. Health transition indicated patient-perceived health status. Conclusions: In study, IHHC alleviated improved suffering from persistent sequelae COVID-19 infection. sustained for up months. Further research is warranted elucidate mechanisms underlying IHHC’s population.

Язык: Английский

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