Photoacoustics, Год журнала: 2022, Номер 28, С. 100410 - 100410
Опубликована: Сен. 28, 2022
Язык: Английский
Chemical Reviews, Год журнала: 2021, Номер 121(15), С. 9243 - 9358
Опубликована: Июль 20, 2021
Research related to the development and application of luminescent nanoparticles (LNPs) for chemical biological analysis imaging is flourishing. Novel materials new applications continue be reported after two decades research. This review provides a comprehensive heuristic overview this field. It targeted both newcomers experts who are interested in critical assessment LNP materials, their properties, strengths weaknesses, prospective applications. Numerous cataloged by fundamental descriptions identities physical morphology, quantitative photoluminescence (PL) PL mechanisms, surface chemistry. These include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, nanodiamonds, metal nanoclusters, lanthanide-doped upconversion downshifting nanoparticles, triplet–triplet annihilation persistent-luminescence conjugated polymer semiconducting multi-nanoparticle assemblies, doped labeled including but not limited those based on polymers silica. As an exercise these ranked several application-related functional criteria. Additional sections highlight recent examples advances analysis, point-of-care diagnostics, cellular, tissue, vivo theranostics. drawn from literature organized material particular properties that leveraged advantage. Finally, perspective what comes next field offered.
Язык: Английский
Процитировано
248
Chemical Society Reviews, Год журнала: 2022, Номер 51(21), С. 8957 - 9008
Опубликована: Янв. 1, 2022
We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.
Язык: Английский
Процитировано
220
ACS Nano, Год журнала: 2019, Номер 13(5), С. 5816 - 5825
Опубликована: Апрель 29, 2019
Tumor phototheranostics in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by inherent nonspecificity from pseudosignal readout undesirable treatment-related side effects. To address these challenges, herein we explore an activatable biocompatible nanotheranostics that generates diagnostic effects only after specific activation enhancement tumor microenvironmental redox acid while keeping silent at normal tissues. Such intelligent "turn-on" chromogenic allows vivo nearly zero-background photoacoustic tomography (PAT) combined effective photothermal therapy (PTT) both range with minimal adverse In light of sensitivity, superior biocompatibility, this stimuli-activatable photo-nanotheranostics provides broad prospects for investigation intervention deep-tissue acid-associated physiological pathological events.
Язык: Английский
Процитировано
181
Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 6850 - 6918
Опубликована: Март 2, 2022
Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.
Язык: Английский
Процитировано
166
Advanced Materials, Год журнала: 2020, Номер 33(3)
Опубликована: Дек. 6, 2020
Precise manipulation of optical properties through the structure-evolution plasmonic nanoparticles is great interest in biomedical fields including bioimaging and phototherapy. However, previous success has been limited to fixed assembled structures or visible–NIR-I absorption. Here, an activatable NIR-II theranostics system based on silica-encapsulated self-assembled gold nanochains (AuNCs@SiO2) for accurate tumor diagnosis effective treatment reported. This transformable chain structure breaks traditional molecular imaging window, whose absorption can be redshifted from visible region owing fusion between adjacent restricted local space AuNCs@SiO2 triggered by high H2O2 level microenvironment (TME), leading generation a new string-like with strong absorption, which further confirmed finite-difference-time-domain (FDTD) simulation. With TME-activated characteristics, exhibits excellent photoacoustic photothermal conversion efficiency 82.2% at 1064 nm severe cell death remarkable growth inhibition vivo. These prominent intelligent TME-responsive features may open up avenue explore regulated nano-platform intelligent, accurate, noninvasive window.
Язык: Английский
Процитировано
157
Journal of the American Chemical Society, Год журнала: 2021, Номер 143(18), С. 7196 - 7202
Опубликована: Апрель 27, 2021
Photoacoustic (PA) imaging has emerged as a reliable in vivo technique for diverse biomedical applications ranging from disease screening to analyte sensing. Most contemporary PA agents employ NIR-I light (650–900 nm) generate an ultrasound signal; however, there is significant interference endogenous biomolecules such hemoglobin that are active this window. Transitioning longer excitation wavelengths (i.e., NIR-II) reduces the background and facilitates detection of low abundance targets (e.g., nitric oxide, NO). In study, we employed two-phase tuning approach develop APNO-1080, NIR-II NO-responsive probe deep-tissue imaging. First, performed Hammett Brønsted analyses identify highly reactive selective aniline-based trigger reacts with NO via N-nitrosation chemistry. Next, screened panel platforms chemical structures have propensity aggregate since can diminish signal. head-to-head comparison analogue, APNO-1080 was 17.7-fold more sensitive vitro tissue phantom assay. To evaluate capabilities vivo, orthotopic breast cancer model heterotopic lung model. Relative control mice not bearing tumors, normalized turn-on response 1.3 ± 0.12 1.65 0.07, respectively.
Язык: Английский
Процитировано
135
ACS Nano, Год журнала: 2023, Номер 17(23), С. 23223 - 23261
Опубликована: Дек. 2, 2023
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.
Язык: Английский
Процитировано
117
Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(18)
Опубликована: Янв. 17, 2022
Abstract Supramolecular interactions rely on non‐covalent forces, such as hydrophobic effects, hydrogen‐bonding, and electrostatic interactions, which govern many intracellular biological pathways. In cellulo supramolecular self‐assembly is mainly based host–guest changes in pH, enzymes, polymerization‐induced to accurately induce various unnatural reactions without disturbing natural processes. This process can produce synthetic biocompatible macromolecules control cell properties regulate functions, proliferation differentiation. Minireview focuses the latest reports field of anticipates future advances regarding its activation response internal external stimuli, pH changes, reactive oxygen species, well light illumination.
Язык: Английский
Процитировано
83
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Окт. 28, 2023
Abstract The formation of an occlusive thrombus in the blood vessel is main culprit for numerous life-threatening cardiovascular diseases that represent leading cause morbidity and mortality worldwide. Herein, we develop a polymer nanoplatform integrates long-wavelength second near-infrared (NIR-II) photoacoustic imaging-based thrombosis detection antithrombotic activity. We design synthesize semiconducting homopolymer with strong absorption NIR-II region molecular motion boosts photothermal conversion signal. dope thermosensitive nitric oxide donor to formulate nanoplatform, on which fibrin-specific ligand functionalized ensure selective targeting. show light harvesting capability, bright signal active accumulation ability, nanoprobes are able sensitively selectively delineate thrombi. find also displays rapid efficient clot removal activity nearly complete flow restoration both carotid models low extremity arterial under trigger by integrating thrombus-localized effect on-demand release. This offers versatile approach diagnosis treatment caused various thrombotic disorders.
Язык: Английский
Процитировано
50
Small, Год журнала: 2023, Номер 19(30)
Опубликована: Апрель 14, 2023
Abstract Photoacoustic imaging (PAI) and imaging‐guided photothermal therapy (PTT) in the second near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to their advantages of greater penetration depth higher signal‐to‐noise ratio. Plasmonic nanomaterials with tunable optical properties strong light absorption provide an alternative dye molecules, showing great prospects for phototheranostic applications. In this review, research progress principally modulating plasmonic nanomaterials, especially affecting parameters such as size, morphology, surface chemical modification, is introduced. The commonly used NIR‐II window, including noble metals, semiconductors, heterostructures, are then summarized. addition, biomedical applications these PAI PTT phototheranostics highlighted. Finally, perspectives challenges advancing practical use clinical translation discussed.
Язык: Английский
Процитировано
43