Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(15), P. 9243 - 9358

Published: July 20, 2021

Research related to the development and application of luminescent nanoparticles (LNPs) for chemical biological analysis imaging is flourishing. Novel materials new applications continue be reported after two decades research. This review provides a comprehensive heuristic overview this field. It targeted both newcomers experts who are interested in critical assessment LNP materials, their properties, strengths weaknesses, prospective applications. Numerous cataloged by fundamental descriptions identities physical morphology, quantitative photoluminescence (PL) PL mechanisms, surface chemistry. These include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, nanodiamonds, metal nanoclusters, lanthanide-doped upconversion downshifting nanoparticles, triplet–triplet annihilation persistent-luminescence conjugated polymer semiconducting multi-nanoparticle assemblies, doped labeled including but not limited those based on polymers silica. As an exercise these ranked several application-related functional criteria. Additional sections highlight recent examples advances analysis, point-of-care diagnostics, cellular, tissue, vivo theranostics. drawn from literature organized material particular properties that leveraged advantage. Finally, perspective what comes next field offered.

Language: Английский

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Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

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Redox-Activatable and Acid-Enhanced Nanotheranostics for Second Near-Infrared Photoacoustic Tomography and Combined Photothermal Tumor Therapy

ACS Nano, Journal Year: 2019, Volume and Issue: 13(5), P. 5816 - 5825

Published: April 29, 2019

Tumor phototheranostics in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by inherent nonspecificity from pseudosignal readout undesirable treatment-related side effects. To address these challenges, herein we explore an activatable biocompatible nanotheranostics that generates diagnostic effects only after specific activation enhancement tumor microenvironmental redox acid while keeping silent at normal tissues. Such intelligent "turn-on" chromogenic allows vivo nearly zero-background photoacoustic tomography (PAT) combined effective photothermal therapy (PTT) both range with minimal adverse In light of sensitivity, superior biocompatibility, this stimuli-activatable photo-nanotheranostics provides broad prospects for investigation intervention deep-tissue acid-associated physiological pathological events.

Language: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6850 - 6918

Published: March 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Language: Английский

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Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(3)

Published: Dec. 6, 2020

Precise manipulation of optical properties through the structure-evolution plasmonic nanoparticles is great interest in biomedical fields including bioimaging and phototherapy. However, previous success has been limited to fixed assembled structures or visible–NIR-I absorption. Here, an activatable NIR-II theranostics system based on silica-encapsulated self-assembled gold nanochains (AuNCs@SiO2) for accurate tumor diagnosis effective treatment reported. This transformable chain structure breaks traditional molecular imaging window, whose absorption can be redshifted from visible region owing fusion between adjacent restricted local space AuNCs@SiO2 triggered by high H2O2 level microenvironment (TME), leading generation a new string-like with strong absorption, which further confirmed finite-difference-time-domain (FDTD) simulation. With TME-activated characteristics, exhibits excellent photoacoustic photothermal conversion efficiency 82.2% at 1064 nm severe cell death remarkable growth inhibition vivo. These prominent intelligent TME-responsive features may open up avenue explore regulated nano-platform intelligent, accurate, noninvasive window.

Language: Английский

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Development of NIR-II Photoacoustic Probes Tailored for Deep-Tissue Sensing of Nitric Oxide

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(18), P. 7196 - 7202

Published: April 27, 2021

Photoacoustic (PA) imaging has emerged as a reliable in vivo technique for diverse biomedical applications ranging from disease screening to analyte sensing. Most contemporary PA agents employ NIR-I light (650–900 nm) generate an ultrasound signal; however, there is significant interference endogenous biomolecules such hemoglobin that are active this window. Transitioning longer excitation wavelengths (i.e., NIR-II) reduces the background and facilitates detection of low abundance targets (e.g., nitric oxide, NO). In study, we employed two-phase tuning approach develop APNO-1080, NIR-II NO-responsive probe deep-tissue imaging. First, performed Hammett Brønsted analyses identify highly reactive selective aniline-based trigger reacts with NO via N-nitrosation chemistry. Next, screened panel platforms chemical structures have propensity aggregate since can diminish signal. head-to-head comparison analogue, APNO-1080 was 17.7-fold more sensitive vitro tissue phantom assay. To evaluate capabilities vivo, orthotopic breast cancer model heterotopic lung model. Relative control mice not bearing tumors, normalized turn-on response 1.3 ± 0.12 1.65 0.07, respectively.

Language: Английский

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Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23223 - 23261

Published: Dec. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Language: Английский

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Supramolecular Self‐Assembly in Living Cells

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(18)

Published: Jan. 17, 2022

Abstract Supramolecular interactions rely on non‐covalent forces, such as hydrophobic effects, hydrogen‐bonding, and electrostatic interactions, which govern many intracellular biological pathways. In cellulo supramolecular self‐assembly is mainly based host–guest changes in pH, enzymes, polymerization‐induced to accurately induce various unnatural reactions without disturbing natural processes. This process can produce synthetic biocompatible macromolecules control cell properties regulate functions, proliferation differentiation. Minireview focuses the latest reports field of anticipates future advances regarding its activation response internal external stimuli, pH changes, reactive oxygen species, well light illumination.

Language: Английский

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Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 28, 2023

Abstract The formation of an occlusive thrombus in the blood vessel is main culprit for numerous life-threatening cardiovascular diseases that represent leading cause morbidity and mortality worldwide. Herein, we develop a polymer nanoplatform integrates long-wavelength second near-infrared (NIR-II) photoacoustic imaging-based thrombosis detection antithrombotic activity. We design synthesize semiconducting homopolymer with strong absorption NIR-II region molecular motion boosts photothermal conversion signal. dope thermosensitive nitric oxide donor to formulate nanoplatform, on which fibrin-specific ligand functionalized ensure selective targeting. show light harvesting capability, bright signal active accumulation ability, nanoprobes are able sensitively selectively delineate thrombi. find also displays rapid efficient clot removal activity nearly complete flow restoration both carotid models low extremity arterial under trigger by integrating thrombus-localized effect on-demand release. This offers versatile approach diagnosis treatment caused various thrombotic disorders.

Language: Английский

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Second Near‐Infrared Plasmonic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy

Small, Journal Year: 2023, Volume and Issue: 19(30)

Published: April 14, 2023

Abstract Photoacoustic imaging (PAI) and imaging‐guided photothermal therapy (PTT) in the second near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to their advantages of greater penetration depth higher signal‐to‐noise ratio. Plasmonic nanomaterials with tunable optical properties strong light absorption provide an alternative dye molecules, showing great prospects for phototheranostic applications. In this review, research progress principally modulating plasmonic nanomaterials, especially affecting parameters such as size, morphology, surface chemical modification, is introduced. The commonly used NIR‐II window, including noble metals, semiconductors, heterostructures, are then summarized. addition, biomedical applications these PAI PTT phototheranostics highlighted. Finally, perspectives challenges advancing practical use clinical translation discussed.

Language: Английский

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