Gene
therapy
(GT)
and
photothermal
(PTT)
have
emerged
as
promising
alternatives
to
chemotherapy
radiotherapy
for
cancer
treatment,
offering
noninvasiveness
reduced
side
effects.
However,
their
efficacy
standalone
treatments
is
limited.
GT
exhibits
slow
response
rates,
while
PTT
confined
local
tumor
ablation.
The
convergence
of
PTT,
known
GT-PTT,
facilitated
by
gene
nanocarriers,
has
attracted
considerable
attention
across
various
disciplines.
In
this
integrated
approach,
reciprocates
sensitizing
cellular
heat,
benefits
improving
translocation,
unpacking,
expression.
Consequently,
integration
presents
a
unique
opportunity
with
rapid
improved
effectiveness.
Extensive
efforts
over
the
past
few
years
been
dedicated
development
resulting
in
notable
achievements
progress
from
laboratory
potential
clinical
applications.
This
comprehensive
review
outlines
recent
advances
including
synergistic
mechanisms,
material
systems,
imaging-guided
therapy,
anticancer
It
also
explores
challenges
future
prospects
nascent
field.
By
presenting
innovative
ideas
insights
into
implementation
GT-PTT
enhanced
aims
inspire
further
area
research.
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 3916 - 3968
Опубликована: Янв. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(3), С. 1861 - 1871
Опубликована: Янв. 22, 2024
Fluorescence
and
photoacoustic
(PA)
imaging
in
the
second
near-infrared
(NIR-II,
1000–1700
nm)
window
has
garnered
massive
interest
owing
to
high
maximum
permissible
exposure
of
light,
reduced
autofluorescence,
improved
deep
penetration.
However,
active
targeted
NIR-II
photoacoustic/NIR-IIa
fluorescence
glioma
under
excitation
been
seldom
reported,
which
is
partly
ascribable
lack
suitable
materials.
In
this
study,
a
small-molecule-based
αvβ3-targeted
fluorescent
probe
IR-32p
was
generated
subsequently
evaluated
U87MG
tumor-bearing
mice
excited
with
NIR-I
light.
Exceptional
dual-modal
properties
such
as
good
tumor
uptake,
targeting
specificity,
contrast
were
achieved
an
orthotopic
model
1020/1064
nm
excitation,
exhibiting
superior
depth
through
skull.
Our
study
introduces
outstanding
agent
absorption
confirms
superiority
over
vivo
NIR-II/PA
imaging.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2020,
Номер
12(4)
Опубликована: Фев. 6, 2020
Abstract
Photoacoustic
imaging
(PAI)
is
a
noninvasive
hybrid
modality
offering
rich
optical
contrast
and
high
depth‐to‐resolution
ratio
deep‐tissue
imaging.
Endogenous
chromophores
present
in
the
body
such
as
hemoglobin,
lipid,
melanin,
so
on
provide
strong
photoacoustic
due
to
their
light
absorption
certain
window.
To
enhance
performance
of
PAI
further,
researchers
have
developed
several
exogenous
agents
metallic
nanoparticles,
carbon‐based
nanomaterials,
quantum
dots,
organic
small
molecules,
semiconducting
polymer
on.
These
not
only
help
improving
contrast,
but
also
make
targeted
molecular
possible.
In
this
review
article,
we
first
discuss
state‐of‐the‐art
techniques
with
endogenous
mechanism.
Later,
an
overview
recent
progress
development
for
vivo
applications.
Finally,
pros/cons
existing
PA
along
future
challenges
agent‐based
biomedical
This
article
categorized
under:
Diagnostic
Tools
>
Nanodevices
Vivo
Nanodiagnostics
Imaging
Physics in Medicine and Biology,
Год журнала:
2020,
Номер
66(5), С. 05TR01 - 05TR01
Опубликована: Дек. 23, 2020
Abstract
Photoacoustic
imaging—a
hybrid
biomedical
imaging
modality
finding
its
way
to
clinical
practices.
Although
the
photoacoustic
phenomenon
was
known
more
than
a
century
back,
only
in
last
two
decades
it
has
been
widely
researched
and
used
for
applications.
In
this
review
we
focus
on
development
progress
of
technology
decade
(2011–2020).
From
becoming
user
friendly,
cheaper
cost,
portable
size,
promises
wide
range
applications,
if
translated
clinic.
The
growth
community
is
steady,
with
several
new
directions
researchers
are
exploring,
inevitable
that
will
one
day
establish
itself
as
regular
system
Micromachines,
Год журнала:
2020,
Номер
11(7), С. 692 - 692
Опубликована: Июль 17, 2020
Ultrasound
detection
is
one
of
the
major
components
photoacoustic
imaging
systems.
Advancement
in
ultrasound
transducer
technology
has
a
significant
impact
on
translation
to
clinic.
Here,
we
present
an
overview
various
technologies
including
conventional
piezoelectric
and
micromachined
transducers,
as
well
optical
technology.
We
explain
core
each
technology,
their
working
principle,
describe
manufacturing
process.
then
quantitatively
compare
performance
when
they
are
used
receive
mode
system.
Theranostics,
Год журнала:
2020,
Номер
10(6), С. 2509 - 2521
Опубликована: Янв. 1, 2020
Photoacoustic
imaging
is
gaining
great
attention
in
the
medical
world
due
to
its
significant
potential
for
clinical
translation.Light
excitation
second
near-infrared
(NIR-II)
window
(1000-1350
nm)
has
resolution
and
penetration
depth
suitable
several
applications.However,
challenge
exists
translation
because
of
absence
notable
intrinsic
chromophores
this
clinically
optical
range
generate
diagnostic
images.Methods:
We
present
newly
developed
a
biocompatible
nickel
dithiolene-based
polymeric
nanoparticle
(NiPNP),
which
have
strong
sharp
absorption
peak
at
1064
nm,
as
photoacoustic
contrast
agent
boost
specific
absorbance
NIR-II
vivo
deep
tissue
imaging.Results:
confirm
enhanced
PA
signal
by
NiPNP's
light
(287%
higher
than
that
NIR-I)
capability
(~5.1
cm)
through
vitro
experiment.We
successfully
acquired
diagnostic-quality
images
(~3.4
sentinel
lymph
nodes,
gastrointestinal
tracts,
bladders
live
rats
using
viable
system.Conclusions:
Our
results
prove
with
deeper
depth,
NiPNP
feasible
preclinical
studies
thus
would
facilitate
further
investigations.
Journal of Nuclear Medicine,
Год журнала:
2020,
Номер
61(10), С. 1419 - 1427
Опубликована: Авг. 6, 2020
With
the
ability
to
noninvasively
image
and
monitor
molecular
processes
within
tumors,
imaging
represents
a
fundamental
tool
for
cancer
scientists.
In
current
review,
we
describe
emergent
optical
technologies
imaging.
We
aim
provide
reader
with
an
overview
of
principles
on
which
each
strategy
is
based,
introduce
established
future
applications,
rationale
selecting
depending
disease
location,
biology,
anatomy.
To
accelerate
clinical
translation
techniques,
also
examples
practical
applications
in
patients.
Elevating
these
techniques
into
standard-of-care
tools
will
transform
patient
stratification,
monitoring,
response
evaluation.
