Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings
STAR Protocols,
Год журнала:
2025,
Номер
6(1), С. 103659 - 103659
Опубликована: Фев. 27, 2025
Язык: Английский
Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity
Journal of Neural Engineering,
Год журнала:
2024,
Номер
21(3), С. 036039 - 036039
Опубликована: Июнь 1, 2024
.
Therapeutic
brain
stimulation
is
conventionally
delivered
using
constant-frequency
pulses.
Several
recent
clinical
studies
have
explored
how
unconventional
and
irregular
temporal
patterns
could
enable
better
therapy.
However,
it
challenging
to
understand
which
are
most
effective
for
different
therapeutic
applications
given
the
massively
high-dimensional
parameter
space.
Язык: Английский
Seizure network characterization by functional connectivity mapping and manipulation
Neurophotonics,
Год журнала:
2025,
Номер
12(S1)
Опубликована: Янв. 16, 2025
Despite
the
availability
of
various
anti-seizure
medications,
nearly
1/3
epilepsy
patients
experience
drug-resistant
seizures.
These
are
left
with
invasive
surgical
options
that
do
not
guarantee
seizure
remission.
The
development
novel
treatment
depends
on
elucidating
complex
biology
seizures
and
brain
networks.
We
aimed
to
develop
an
experimental
paradigm
uses
anatomical
network
information,
functional
connectivity,
in
vivo
models
determine
how
networks,
their
manipulation,
affect
propagation.
Guided
by
a
known
network,
we
applied
widefield
calcium
imaging
neural
activity
spread
through
regions,
focusing
primary
somatosensory
cortex
secondary
motor
cortex.
used
microstimulation
induce
suprathreshold
excitatory
activation
compared
this
reproducible
stimulus
acute
pharmacologically
induced
spontaneous
In
proof-of-concept
experiment,
ablated
single
node
within
bilateral
measured
effect
propagation
recruitment.
Similar
preliminary
experiments
were
repeated
chronic
model.
propagated
distinct
pattern
throughout
sequential
Seizures
recapitulated
same
pattern,
indicating
hijacking
existing
pathways.
Ablation
key
changed
contralateral
spread.
Early
cobalt
data
presented.
Here,
demonstrate
for
combining
microstimulation,
cortical
ablation,
mapping
networks
inform
patterns
can
be
extended
long-term
tracking
study
epileptogenesis
other
Our
findings
suggest
may
useful
therapies
disorders
involving
Язык: Английский
SAFE-OPT: a Bayesian optimization algorithm for learning optimal deep brain stimulation parameters with safety constraints
Journal of Neural Engineering,
Год журнала:
2024,
Номер
21(4), С. 046054 - 046054
Опубликована: Авг. 1, 2024
To
treat
neurological
and
psychiatric
diseases
with
deep
brain
stimulation
(DBS),
a
trained
clinician
must
select
parameters
for
each
patient
by
monitoring
their
symptoms
side-effects
in
months-long
trial-and-error
process,
delaying
optimal
clinical
outcomes.
Bayesian
optimization
has
been
proposed
as
an
efficient
method
to
quickly
automatically
search
parameters.
However,
conventional
does
not
account
safety
could
trigger
unwanted
or
dangerous
side-effects.
Язык: Английский
Epilepsy insights revealed by intravital functional optical imaging
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 29, 2024
Despite
an
abundance
of
pharmacologic
and
surgical
epilepsy
treatments,
there
remain
millions
patients
suffering
from
poorly
controlled
seizures.
One
approach
to
closing
this
treatment
gap
may
be
found
through
a
deeper
mechanistic
understanding
the
network
alterations
that
underly
aberrant
activity.
Functional
optical
imaging
in
vertebrate
models
provides
powerful
advantages
end,
enabling
spatiotemporal
acquisition
individual
neuron
activity
patterns
across
multiple
This
coupled
with
advent
genetically
encoded
indicators,
them
for
specific
ions,
neurotransmitters
or
voltage,
grants
researchers
unparalleled
access
intact
nervous
system.
Here,
we
will
review
how
vivo
functional
various
seizure
has
advanced
our
knowledge
dynamics,
principally
initiation,
propagation
termination.
Язык: Английский