Epilepsy insights revealed by intravital functional optical imaging DOI Creative Commons
Matthew Stern, Raymond Dingledine, Robert A. Gross

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain millions patients suffering from poorly controlled seizures. One approach to closing this treatment gap may be found through a deeper mechanistic understanding the network alterations that underly aberrant activity. Functional optical imaging in vertebrate models provides powerful advantages end, enabling spatiotemporal acquisition individual neuron activity patterns across multiple This coupled with advent genetically encoded indicators, them for specific ions, neurotransmitters or voltage, grants researchers unparalleled access intact nervous system. Here, we will review how vivo functional various seizure has advanced our knowledge dynamics, principally initiation, propagation termination.

Language: Английский

Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings DOI Creative Commons

Veronica M Zarr,

Jyun-you Liou, Edward M. Merricks

et al.

STAR Protocols, Journal Year: 2025, Volume and Issue: 6(1), P. 103659 - 103659

Published: Feb. 27, 2025

Language: Английский

Citations

0
Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity DOI Creative Commons
Eric R. Cole, Thomas E. Eggers, David Weiß

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(3), P. 036039 - 036039

Published: June 1, 2024

. Therapeutic brain stimulation is conventionally delivered using constant-frequency pulses. Several recent clinical studies have explored how unconventional and irregular temporal patterns could enable better therapy. However, it challenging to understand which are most effective for different therapeutic applications given the massively high-dimensional parameter space.

Language: Английский

Citations

3
Seizure network characterization by functional connectivity mapping and manipulation DOI Creative Commons
James E. Niemeyer,

Peijuan Luo,

Carmen Pons

et al.

Neurophotonics, Journal Year: 2025, Volume and Issue: 12(S1)

Published: Jan. 16, 2025

Despite the availability of various anti-seizure medications, nearly 1/3 epilepsy patients experience drug-resistant seizures. These are left with invasive surgical options that do not guarantee seizure remission. The development novel treatment depends on elucidating complex biology seizures and brain networks. We aimed to develop an experimental paradigm uses anatomical network information, functional connectivity, in vivo models determine how networks, their manipulation, affect propagation. Guided by a known network, we applied widefield calcium imaging neural activity spread through regions, focusing primary somatosensory cortex secondary motor cortex. used microstimulation induce suprathreshold excitatory activation compared this reproducible stimulus acute pharmacologically induced spontaneous In proof-of-concept experiment, ablated single node within bilateral measured effect propagation recruitment. Similar preliminary experiments were repeated chronic model. propagated distinct pattern throughout sequential Seizures recapitulated same pattern, indicating hijacking existing pathways. Ablation key changed contralateral spread. Early cobalt data presented. Here, demonstrate for combining microstimulation, cortical ablation, mapping networks inform patterns can be extended long-term tracking study epileptogenesis other Our findings suggest may useful therapies disorders involving

Language: Английский

Citations

0
SAFE-OPT: a Bayesian optimization algorithm for learning optimal deep brain stimulation parameters with safety constraints DOI Creative Commons
Eric R. Cole, Mark Connolly,

Mihir Ghetiya

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(4), P. 046054 - 046054

Published: Aug. 1, 2024

To treat neurological and psychiatric diseases with deep brain stimulation (DBS), a trained clinician must select parameters for each patient by monitoring their symptoms side-effects in months-long trial-and-error process, delaying optimal clinical outcomes. Bayesian optimization has been proposed as an efficient method to quickly automatically search parameters. However, conventional does not account safety could trigger unwanted or dangerous side-effects.

Language: Английский

Citations

2
Epilepsy insights revealed by intravital functional optical imaging DOI Creative Commons
Matthew Stern, Raymond Dingledine, Robert A. Gross

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain millions patients suffering from poorly controlled seizures. One approach to closing this treatment gap may be found through a deeper mechanistic understanding the network alterations that underly aberrant activity. Functional optical imaging in vertebrate models provides powerful advantages end, enabling spatiotemporal acquisition individual neuron activity patterns across multiple This coupled with advent genetically encoded indicators, them for specific ions, neurotransmitters or voltage, grants researchers unparalleled access intact nervous system. Here, we will review how vivo functional various seizure has advanced our knowledge dynamics, principally initiation, propagation termination.

Language: Английский

Citations

0