Advanced Materials,
Год журнала:
2021,
Номер
33(26)
Опубликована: Май 25, 2021
Abstract
Flexible
and
stretchable
antennas
are
important
for
wireless
communication
using
wearable
implantable
devices
to
address
mechanical
mismatch
at
the
tissue–device
interface.
Emerging
technologies
of
liquid‐metal‐based
electronics
promising
approaches
improve
flexibility
stretchability
conventional
metal‐based
antennas.
However,
existing
methods
encapsulate
liquid
metals
require
monolithically
thick
(at
least
100
µm)
substrates,
resulting
limited
in
deformability
tissue‐adhesiveness.
To
overcome
this
limitation,
fabrication
microchannels
by
direct
ink
writing
on
a
7
µm‐thick
elastomeric
substrate
is
demonstrated,
obtain
metal
microfluidic
with
unprecedented
deformability.
The
fabricated
light‐emitting
device
powered
standard
near‐field‐communication
system
(13.56
MHz,
1
W)
retained
consistent
operation
under
deformations
including
stretching
(>200%
uniaxial
strain),
twisting
(180°
twist),
bending
(3.0
mm
radius
curvature)
while
maintaining
high
quality
factor
(
q
>
20).
Suture‐free
conformal
adhesion
polydopamine‐coated
ex
vivo
animal
tissues
also
demonstrated.
This
technology
offers
new
capability
design
biomedical
requiring
conformable
tissue‐device
integration
toward
minimally
invasive,
imperceptible
medical
treatments.
Physiological Reviews,
Год журнала:
2022,
Номер
102(3), С. 1263 - 1325
Опубликована: Янв. 24, 2022
Optogenetics
combines
light
and
genetics
to
enable
precise
control
of
living
cells,
tissues,
organisms
with
tailored
functions.
has
the
advantages
noninvasiveness,
rapid
responsiveness,
tunable
reversibility,
superior
spatiotemporal
resolution.
Following
initial
discovery
microbial
opsins
as
light-actuated
ion
channels,
a
plethora
naturally
occurring
or
engineered
photoreceptors
photosensitive
domains
that
respond
at
varying
wavelengths
ushered
in
next
chapter
optogenetics.
Through
protein
engineering
synthetic
biology
approaches,
genetically
encoded
photoswitches
can
be
modularly
into
scaffolds
host
cells
myriad
biological
processes,
well
behavioral
disease
intervention
vivo.
Here,
we
summarize
these
optogenetic
tools
on
basis
their
fundamental
photochemical
properties
better
inform
chemical
design
principles.
We
also
highlight
exemplary
applications
opsin-free
optogenetics
dissecting
cellular
physiology
(designated
"optophysiology")
describe
current
progress,
future
trends,
wireless
optogenetics,
which
enables
remote
interrogation
physiological
processes
minimal
invasiveness.
This
review
is
anticipated
spark
novel
thoughts
next-generation
devices
promise
accelerate
both
basic
translational
studies.
Miniature
wireless
bioelectronic
implants
that
can
operate
for
extended
periods
of
time
transform
how
we
treat
disorders
by
acting
rapidly
on
precise
nerves
and
organs
in
a
way
drugs
cannot.
To
reach
this
goal,
materials
methods
are
needed
to
wirelessly
transfer
energy
through
the
body
or
harvest
from
itself.
We
review
some
capabilities
emerging
identify
performance
envelope
existing
technology
discover
where
opportunities
lie
improve
much-and
efficiently-we
deliver
tiny
support
medical
technologies.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(8)
Опубликована: Янв. 10, 2023
Abstract
Advances
in
implantable
bioelectronics
for
the
nervous
system
are
reinventing
stimulation,
inhibition,
and
sensing
of
neuronal
activity.
These
efforts
promise
not
just
breakthrough
treatments
several
neurological
psychiatric
conditions
but
also
signal
beginning
a
new
era
computer‐controlled
human
therapeutics.
Batteries
remain
major
power
source
all
implanted
electrical
neuromodulation
devices,
which
impairs
miniaturization
necessitates
replacement
surgery
when
battery
is
drained.
Triboelectric
nanogenerators
(TENGs)
have
recently
emerged
as
an
innovative
solution
self‐powered,
closed
loop
neurostimulation
devices.
TENGs
can
leverage
biomechanical
activities
different
body
organs
to
sustainably
generate
electricity
neurostimulation.
This
review
features
advances
they
pave
way
self‐sustainable
A
comprehensive
TENG
research
brain,
autonomic,
somatic
systems
provided.
The
direction
growth
this
field,
publication
trends,
modes
discussed.
Finally,
insightful
outlook
into
challenges
facing
neuromodulators
reach
clinical
practice
provided,
solutions
maladies
proposed.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2205 - 2280
Опубликована: Фев. 21, 2024
Advances
in
soft
materials,
miniaturized
electronics,
sensors,
stimulators,
radios,
and
battery-free
power
supplies
are
resulting
a
new
generation
of
fully
implantable
organ
interfaces
that
leverage
volumetric
reduction
mechanics
by
eliminating
electrochemical
storage.
This
device
class
offers
the
ability
to
provide
high-fidelity
readouts
physiological
processes,
enables
stimulation,
allows
control
over
organs
realize
therapeutic
diagnostic
paradigms.
Driven
seamless
integration
with
connected
infrastructure,
these
devices
enable
personalized
digital
medicine.
Key
advances
carefully
designed
material,
electrophysical,
electrochemical,
electromagnetic
systems
form
implantables
mechanical
properties
closely
matched
target
deliver
functionality
supports
sensors
stimulators.
The
elimination
operation,
anywhere
from
acute,
lifetimes
matching
subject
physical
dimensions
imperceptible
operation.
review
provides
comprehensive
overview
basic
building
blocks
related
topics
such
as
implantation,
delivery,
sterilization,
user
acceptance.
State
art
examples
categorized
system
an
outlook
interconnection
advanced
strategies
for
computation
leveraging
consistent
influx
elevate
this
current
battery-powered
is
highlighted.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(3), С. 495 - 511
Опубликована: Фев. 24, 2024
Breast
cancer
is
a
global
health
concern
that
demands
attention.
In
our
contribution
to
addressing
this
disease,
study
focuses
on
investigating
wireless
micro-device
for
intratumoral
drug
delivery,
utilizing
electrochemical
actuation.
Microdevices
have
emerged
as
promising
approach
in
field
due
their
ability
enable
controlled
injections
various
applications.
Proceedings of the National Academy of Sciences,
Год журнала:
2019,
Номер
116(43), С. 21427 - 21437
Опубликована: Окт. 10, 2019
Significance
Neuroscience
studies
using
optogenetics
have
greatly
improved
our
understanding
of
brain
circuits.
Advances
in
the
combined
use
and
pharmacology
to
further
probe
important
neurochemical
signals
has
lagged,
however,
large
part
due
inconvenience
conventional
cannulated
approaches,
as
well
difficulty
controlling,
powering,
manufacturing
optofluidic
devices
that
are
reliable
scalable
for
distribution
neuroscience
community.
Here,
we
present
a
battery-free,
wireless,
lightweight
device
allows
adjustable
infusion
rates,
hands-free
operation,
unlimited
power
supply,
is
compatible
with
existing
near-field
communication
(NFC)
technology.
We
show
this
not
only
reproduces
optogenetic
pharmacological
experiments
vivo
but,
additionally,
far
greater
freedom
movement
small
animal
models
compared
existing,
comparable
platforms.
