Bioactive Materials,
Год журнала:
2021,
Номер
6(12), С. 4402 - 4414
Опубликована: Май 1, 2021
Nanosuspensions,
as
a
new
drug
delivery
system
for
insoluble
drugs,
are
only
composed
of
and
small
amount
stabilizer,
which
is
dispersed
in
an
aqueous
solution
with
high
drug-loading,
particle
size,
dispersion,
large
specific
surface
area.
It
can
significantly
improve
the
dissolution,
bioavailability,
efficacy
drugs.
In
this
study,
paclitaxel
nanosuspensions
((PTX)NS)
were
prepared
by
ultrasonic
precipitation
method,
characteristics
simple
preparation
easy
repetition.
With
help
homologous
targeting
mechanism,
kind
glioma
C6
cancer
cell
membrane
(CCM)-coated
(PTX)NS
was
developed
modified
DWSW
peptide
to
obtain
DWSW-CCM-(PTX)NS
functions
BBB
penetration
tumor
targeting.
The
results
showed
that
could
effectively
camouflage
so
it
not
cleared
immune
cross
blood-brain-barrier
(BBB)
selectively
target
tissues.
Cell
uptake
experiments
vivo
imaging
confirmed
cells
distribution
intracranial
gliomas
increased.
Cytotoxicity
test
anti-glioma
studies
inhibit
growth
prolong
survival
time
glioma-bearing
mice.
Finally,
coating
endowed
biological
properties
adhesion
escape.
This
study
provides
integrated
improving
demonstrates
encouraging
potential
biomimetic
applicable
therapy.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Сен. 30, 2021
Cell
membrane
coated
nanoparticles
(NPs)
have
recently
been
recognized
as
attractive
nanomedical
tools
because
of
their
unique
properties
such
immune
escape,
long
blood
circulation
time,
specific
molecular
recognition
and
cell
targeting.
However,
the
integrity
coating
on
NPs,
a
key
metrics
related
to
quality
these
biomimetic-systems
resulting
biomedical
function,
has
remained
largely
unexplored.
Here,
we
report
fluorescence
quenching
assay
probe
coating.
In
contradiction
common
assumption
perfect
coating,
uncover
that
up
90%
biomimetic
NPs
are
only
partially
coated.
Using
in
vitro
homologous
targeting
studies,
demonstrate
could
still
be
internalized
by
target
cells.
By
combining
simulations
with
experimental
analysis,
further
identify
an
endocytic
entry
mechanism
for
NPs.
We
unravel
high
degree
(≥50%)
enter
cells
individually,
whereas
low
(<50%)
need
aggregate
together
before
internalization.
This
quantitative
method
fundamental
understanding
how
will
enhance
rational
designing
nanosystems
pave
way
more
effective
cancer
nanomedicine.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Июнь 7, 2021
Abstract
Over
the
past
decades,
great
interest
has
been
given
to
biomimetic
nanoparticles
(BNPs)
since
rise
of
targeted
drug
delivery
systems
and
nanotechnology.
Biological
vectors
including
cell
membranes,
extracellular
vesicles
(EVs),
viruses
are
considered
promising
candidates
for
owing
their
biocompatibility
biodegradability.
BNPs,
integration
biological
functional
agents,
anticipated
load
cargos
or
camouflage
synthetic
achieve
delivery.
Despite
excellent
intrinsic
properties,
natural
deliberately
modified
endow
multiple
functions
such
as
good
permeability,
improved
loading
capability,
high
specificity.
Through
structural
modification
transformation
vectors,
they
pervasively
utilized
more
effective
vehicles
that
can
deliver
contrast
chemotherapy
drugs,
nucleic
acids,
genes
target
sites
refractory
disease
therapy.
This
review
summarizes
recent
advances
in
based
on
EVs,
viruses,
highlighting
potential
applications
BNPs
fields
biomedical
imaging
therapy
industry,
well
discussing
possibility
clinical
translation
exploitation
trend
these
BNPs.
ACS Nano,
Год журнала:
2021,
Номер
15(2), С. 2068 - 2098
Опубликована: Фев. 8, 2021
Materials
that
respond
to
endogenous
stimuli
are
being
leveraged
enhance
spatiotemporal
control
in
a
range
of
biomedical
applications
from
drug
delivery
diagnostic
tools.
The
design
materials
undergo
morphological
or
chemical
changes
response
specific
biological
cues
pathologies
will
be
an
important
area
research
for
improving
efficacies
existing
therapies
and
imaging
agents,
while
also
promising
developing
personalized
theranostic
systems.
Internal
stimuli-responsive
systems
can
engineered
across
length
scales
nanometers
macroscopic
signals
such
as
enzymes,
pH,
glucose,
ATP,
hypoxia,
redox
signals,
nucleic
acids
by
incorporating
synthetic
bio-inspired
moieties
natural
building
blocks.
This
Review
summarize
mechanisms
fabrication
strategies
used
internal
with
focus
on
broad
pathologies,
including
cancer,
diabetes,
vascular
disorders,
inflammation,
microbial
infections.
We
discuss
observed
challenges,
future
directions,
clinical
translation
aspects
these
responsive
materials.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Апрель 13, 2023
Nanomaterial-based
drug
delivery
systems
(NBDDS)
are
widely
used
to
improve
the
safety
and
therapeutic
efficacy
of
encapsulated
drugs
due
their
unique
physicochemical
biological
properties.
By
combining
with
nanoparticles
using
rational
targeting
pathways,
nano-targeted
were
created
overcome
main
drawbacks
conventional
treatment,
including
insufficient
stability
solubility,
lack
transmembrane
transport,
short
circulation
time,
undesirable
toxic
effects.
Herein,
we
reviewed
recent
developments
in
different
design
strategies
approaches
employing
various
nanomaterial-based
systems.
We
also
discussed
challenges
perspectives
smart
precisely
intravascular
extravascular
diseases.
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(8), С. 2096 - 2113
Опубликована: Фев. 2, 2021
Cell
membranes
have
recently
emerged
as
a
new
source
of
materials
for
molecular
delivery
systems.
been
extruded
or
sonicated
to
make
nanoscale
vesicles.
Unlike
synthetic
lipid
polymeric
nanoparticles,
cell
membrane-derived
vesicles
unique
multicomponent
feature,
comprising
lipids,
proteins,
and
carbohydrates.
Because
contain
the
intrinsic
functionalities
signaling
networks
their
parent
cells,
they
can
overcome
various
obstacles
encountered
Advanced Materials,
Год журнала:
2022,
Номер
34(33)
Опубликована: Июнь 23, 2022
Glioblastoma
(GBM)
is
an
intractable
malignancy
with
high
recurrence
and
mortality.
Combinatorial
therapy
based
on
temozolomide
(TMZ)
cisplatin
(CDDP)
shows
promising
potential
for
GBM
in
clinical
trials.
However,
significant
challenges
include
limited
blood-brain-barrier
(BBB)
penetration,
poor
targeting
of
tissue/cells,
systemic
side
effects,
which
hinder
its
efficacy
therapy.
To
surmount
these
challenges,
new
GBM-cell
membrane
camouflaged
pH-sensitive
biomimetic
nanoparticles
(MNPs)
inspired
by
the
fact
that
cancer
cells
readily
pass
BBB
localize
homologous
cells,
are
developed.
This
study's
results
show
MNPs
can
efficiently
co-load
TMZ
CDDP,
transport
across
to
specifically
target
GBM.
Incorporation
polymer
then
allows
controlled
release
drug
cargos
at
sites
combination
Mice
bearing
orthotopic
U87MG
or
drug-resistant
U251R
tumor
treated
MNPs@TMZ+CDDP
a
potent
anti-GBM
effect,
greatly
extending
survival
time
relative
mice
receiving
single-drug
loaded
nanoparticles.
No
obvious
effects
apparent
histological
analyses
blood
routine
studies.
Considering
results,
nanoparticle
formulation
overcomes
multiple
currently
limiting
combined
CDDP
appears
be
strategy
future
combinatorial
chemotherapy.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5187 - 5210
Опубликована: Март 10, 2023
Red
blood
cells
(RBCs)
and
RBC
membrane-derived
nanoparticles
have
been
historically
developed
as
bioinspired
drug
delivery
systems
to
combat
the
issues
of
premature
clearance,
toxicity,
immunogenicity
synthetic
nanocarriers.
RBC-based
possess
characteristics
including
biocompatibility,
biodegradability,
long
circulation
time,
which
make
them
suited
for
systemic
administration.
Therefore,
they
employed
in
designing
optimal
formulations
various
preclinical
models
clinical
trials
treat
a
wide
range
diseases.
In
this
review,
we
provide
an
overview
biology,
synthesis,
characterization
based
on
RBCs
their
membrane
whole
RBCs,
membrane-camouflaged
nanoparticles,
RBC-derived
extracellular
vesicles,
hitchhiking.
We
also
highlight
conventional
latest
engineering
strategies,
along
with
therapeutic
modalities,
enhanced
precision
effectiveness
delivery.
Additionally,
focus
current
state
applications
translation
carriers,
well
discussing
opportunities
challenges
associated
these
systems.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Окт. 19, 2022
Cell
membrane
(CM)
coating
technology
is
increasingly
being
applied
in
nanomedicine,
but
the
entire
procedure
including
adsorption,
rupture,
and
fusion
not
completely
understood.
Previously,
we
showed
that
majority
of
biomimetic
nanoparticles
(NPs)
were
only
partially
coated,
mechanism
underlying
this
partial
remains
unclear,
which
hinders
further
improvement
technique.
Here,
show
an
intermediate
state
due
to
adsorption
CM
fragments
or
vesicles,
latter
could
eventually
be
ruptured
under
external
force.
Such
difficult
self-repair
achieve
full
limited
fluidity.
Building
on
our
understanding
detailed
process,
develop
a
general
approach
for
fixing
coating:
phospholipid
introduced
as
helper
increase
fluidity,
promoting
final
lipid
patches.
The
NPs
coated
with
have
high
ratio
(~23%)
exhibit
enhanced
tumor
targeting
ability
comparison
traditionally
(full
~6%).
Our
results
provide
mechanistic
basis
towards
enhancing
accumulation.