Bioactive Materials,
Год журнала:
2021,
Номер
6(12), С. 4402 - 4414
Опубликована: Май 1, 2021
Nanosuspensions,
as
a
new
drug
delivery
system
for
insoluble
drugs,
are
only
composed
of
and
small
amount
stabilizer,
which
is
dispersed
in
an
aqueous
solution
with
high
drug-loading,
particle
size,
dispersion,
large
specific
surface
area.
It
can
significantly
improve
the
dissolution,
bioavailability,
efficacy
drugs.
In
this
study,
paclitaxel
nanosuspensions
((PTX)NS)
were
prepared
by
ultrasonic
precipitation
method,
characteristics
simple
preparation
easy
repetition.
With
help
homologous
targeting
mechanism,
kind
glioma
C6
cancer
cell
membrane
(CCM)-coated
(PTX)NS
was
developed
modified
DWSW
peptide
to
obtain
DWSW-CCM-(PTX)NS
functions
BBB
penetration
tumor
targeting.
The
results
showed
that
could
effectively
camouflage
so
it
not
cleared
immune
cross
blood-brain-barrier
(BBB)
selectively
target
tissues.
Cell
uptake
experiments
vivo
imaging
confirmed
cells
distribution
intracranial
gliomas
increased.
Cytotoxicity
test
anti-glioma
studies
inhibit
growth
prolong
survival
time
glioma-bearing
mice.
Finally,
coating
endowed
biological
properties
adhesion
escape.
This
study
provides
integrated
improving
demonstrates
encouraging
potential
biomimetic
applicable
therapy.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(52), С. 21702 - 21711
Опубликована: Дек. 16, 2020
Clearance
of
peripheral
amyloid-β
(Aβ)
has
been
demonstrated
to
be
promising
for
overcoming
the
blood–brain
barrier
(BBB)
hurdle
eliminate
brain-derived
Aβ
associated
with
Alzheimer's
disease
(AD).
Even
so,
current
developed
therapeutic
assays
clearance
are
still
facing
challenges
on
how
avoid
interference
certain
biological
molecules
and
prevent
triggering
activation
immune
responses
blood
clotting.
Here,
a
biomimetic
nanozyme
(CuxO@EM-K)
augmented
protein
adsorption
resistance,
minimized
immunogenicity,
enhanced
biocompatibility
is
designed
synthesized.
The
CuxO@EM-K
made
CuxO
wrapped
modified
3xTg-AD
mouse
erythrocyte
membrane
Aβ-targeting
pentapeptide
KLVFF.
KLVFF
serves
as
Aβ-specific
ligand
that
works
together
selectively
capture
in
blood.
Meanwhile,
coating
prevents
coronas
formation
thus
retains
ability
fluids.
More
importantly,
core
multiple
antioxidant
enzyme-like
activities
stabilizes
outer
simultaneously
mitigates
Aβ-induced
oxidative
damage,
which
enables
extended
systemic
circulation
indispensable
adsorbing
Aβ.
In
vivo
studies
demonstrate
not
only
reduces
burden
brain
but
also
ameliorates
memory
deficits
widely
used
model.
Moreover,
shows
no
apparent
toxicity
mice.
Overall,
this
work
provides
an
example
developing
biocompatible
synergistic
AD.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(23)
Опубликована: Март 25, 2021
Abstract
Immunotherapy
is
leading
a
paradigm
shift
in
the
treatment
of
various
diseases,
including
tumors,
auto‐immune
and
infectious
diseases.
However,
limited
response
rate
systemic
side
effects
significantly
impede
clinical
applications
immunotherapy.
As
natural
carriers
for
proteins
molecules,
cells
with
low
immunogenicity
toxicity
have
attracted
considerable
attention
biomedical
achieved
encouraging
progress
especially
The
convergence
multiple
disciplines
has
equipped
cell‐based
delivery
systems
control
over
their
spatiotemporal
distribution
to
enhance
efficacy
reduce
effects.
Here,
an
overview
fundamentals
design
principles
followed
by
perspective
that
includes
most
recent
advances
as
carriers,
special
focus
on
implications
immunotherapy
offered.
Abstract
Gene
therapy
provides
a
promising
strategy
for
curing
monogenetic
disorders
and
complex
diseases.
However,
there
are
challenges
associated
with
the
use
of
viral
delivery
vectors.
The
advent
nanomedicine
represents
quantum
leap
in
application
gene
therapy.
Recent
advances
stimulus‐responsive
nonviral
nanocarriers
indicate
that
they
efficient
systems
loading
unloading
therapeutic
nucleic
acids.
Some
responsive
to
cues
derived
from
internal
environment,
such
as
changes
pH,
redox
potential,
enzyme
activity,
reactive
oxygen
species,
adenosine
triphosphate,
hypoxia.
Others
external
stimulations,
including
temperature
gradients,
light
irradiation,
ultrasonic
energy,
magnetic
field.
Multiple
stimuli‐responsive
strategies
have
also
been
investigated
recently
experimental
Bioactive Materials,
Год журнала:
2021,
Номер
6(12), С. 4402 - 4414
Опубликована: Май 1, 2021
Nanosuspensions,
as
a
new
drug
delivery
system
for
insoluble
drugs,
are
only
composed
of
and
small
amount
stabilizer,
which
is
dispersed
in
an
aqueous
solution
with
high
drug-loading,
particle
size,
dispersion,
large
specific
surface
area.
It
can
significantly
improve
the
dissolution,
bioavailability,
efficacy
drugs.
In
this
study,
paclitaxel
nanosuspensions
((PTX)NS)
were
prepared
by
ultrasonic
precipitation
method,
characteristics
simple
preparation
easy
repetition.
With
help
homologous
targeting
mechanism,
kind
glioma
C6
cancer
cell
membrane
(CCM)-coated
(PTX)NS
was
developed
modified
DWSW
peptide
to
obtain
DWSW-CCM-(PTX)NS
functions
BBB
penetration
tumor
targeting.
The
results
showed
that
could
effectively
camouflage
so
it
not
cleared
immune
cross
blood-brain-barrier
(BBB)
selectively
target
tissues.
Cell
uptake
experiments
vivo
imaging
confirmed
cells
distribution
intracranial
gliomas
increased.
Cytotoxicity
test
anti-glioma
studies
inhibit
growth
prolong
survival
time
glioma-bearing
mice.
Finally,
coating
endowed
biological
properties
adhesion
escape.
This
study
provides
integrated
improving
demonstrates
encouraging
potential
biomimetic
applicable
therapy.
