International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5171 - 5171
Опубликована: Май 9, 2024
Nanoparticles
(NPs)
are
extremely
important
tools
to
overcome
the
limitations
imposed
by
therapeutic
agents
and
effectively
biological
barriers.
Smart
designed/tuned
nanostructures
can
be
effective
for
cancer
treatment.
The
selection
design
of
adjustment
size
surface
properties
important,
especially
some
precision
treatments
drug
delivery
(DD).
By
designing
specific
methods,
an
era
opened
in
biomedical
field
personalized
precise
Here,
we
focus
on
advances
nanostructures,
as
well
how
structure
shape,
size,
charge,
fluids
(BFs)
affected.
We
discussed
applications
specialized
therapy
head
neck
(HNC),
which
is
a
difficult
aggressive
type
treat,
give
impetus
novel
treatment
approaches
this
field.
also
comprehensively
touched
shortcomings,
current
trends,
future
perspectives
when
using
cancer.
Molecules,
Год журнала:
2023,
Номер
28(18), С. 6624 - 6624
Опубликована: Сен. 14, 2023
Knowing
the
beneficial
aspects
of
nanomedicine,
scientists
are
trying
to
harness
applications
nanotechnology
in
diagnosis,
treatment,
and
prevention
diseases.
There
also
potential
uses
designing
medical
tools
processes
for
new
generation
scientists.
The
main
objective
conducting
this
research
review
is
gather
widespread
nanomedicine
under
one
heading
highlight
standard
practices
field.
Comprehensive
has
been
conducted
incorporate
latest
data
related
medicine
therapeutics
derived
from
acknowledged
scientific
platforms.
Nanotechnology
used
conduct
sensitive
procedures.
showing
successful
fields
diagnostics,
disease
regenerative
medicine,
gene
therapy,
dentistry,
oncology,
aesthetics
industry,
drug
delivery,
therapeutics.
A
thorough
association
cooperation
between
physicians,
clinicians,
researchers,
technologies
will
bring
forward
a
future
where
there
more
calculated,
outlined,
technically
programed
field
nanomedicine.
Advances
being
made
overcome
challenges
associated
with
application
due
pathophysiological
basis
This
highlights
multipronged
how
proving
health
industry.
need
minimize
health,
environmental,
ethical
concerns
linked
nanotechnology.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23223 - 23261
Опубликована: Дек. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июнь 26, 2023
Abstract
Exosomal
circRNA
serves
a
novel
genetic
information
molecule,
facilitating
communication
between
tumor
cells
and
microenvironmental
cells,
such
as
immune
fibroblasts,
other
components,
thereby
regulating
critical
aspects
of
cancer
progression
including
escape,
angiogenesis,
metabolism,
drug
resistance,
proliferation
metastasis.
Interestingly,
microenvironment
have
new
findings
in
influencing
escape
mediated
by
the
release
exosomal
circRNA.
Given
intrinsic
stability,
abundance,
broad
distribution
circRNAs,
they
represent
excellent
diagnostic
prognostic
biomarkers
for
liquid
biopsy.
Moreover,
artificially
synthesized
circRNAs
may
open
up
possibilities
therapy,
potentially
bolstered
nanoparticles
or
plant
exosome
delivery
strategies.
In
this
review,
we
summarize
functions
underlying
mechanisms
cell
non-tumor
cell-derived
progression,
with
special
focus
on
their
roles
immunity
metabolism.
Finally,
examine
potential
application
therapeutic
targets,
highlighting
promise
clinical
use.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 16, 2023
Nanoparticle
drug
delivery
systems
have
proved
anti-tumor
effects;
however,
they
are
not
widely
used
in
tumor
therapy
due
to
insufficient
ability
target
specific
sites,
multidrug
resistance
drugs,
and
the
high
toxicity
of
drugs.
With
development
RNAi
technology,
nucleic
acids
been
delivered
sites
replace
or
correct
defective
genes
knock
down
genes.
Also,
synergistic
therapeutic
effects
can
be
achieved
for
combined
delivery,
which
is
more
effective
overcoming
cancer
cells.
These
combination
therapies
achieve
better
than
delivering
chemotherapeutic
drugs
alone,
so
scope
has
also
expanded
three
aspects:
drug-drug,
drug-gene,
gene-gene.
This
review
summarizes
recent
advances
nanocarriers
co-delivery
agents,
including
i)
characterization
preparation
nanocarriers,
such
as
lipid-based
polymer
inorganic
carriers;
ii)
advantages
disadvantages
approaches;
iii)
effectual
cases
that
applied
systems;
iv)
future
perspectives
design
nanoparticle
co-deliver
agents.
Heliyon,
Год журнала:
2024,
Номер
10(4), С. e26009 - e26009
Опубликована: Фев. 1, 2024
Drug-delivery
systems
(DDSs)
are
designed
to
deliver
drugs
their
specific
targets
minimize
toxic
effects
and
improve
susceptibility
clearance
during
targeted
transport.
Peptides
have
high
affinity,
low
immunogenicity,
simple
amino
acid
composition,
adjustable
molecular
size;
therefore,
most
peptides
can
be
coupled
via
linkers
form
peptide-drug
conjugates
(PDCs)
act
as
active
pro-drugs.
PDCs
widely
thought
promising
DDSs,
given
ability
drug
bio-compatibility
physiological
stability.
Peptide-based
DDSs
often
used
therapeutic
substances
such
anti-cancer
nucleic
acid-based
drugs,
which
not
only
slow
the
degradation
rate
of
in
vivo
but
also
ensure
concentration
at
site
prolong
half-life
vivo.This
article
provides
an
profile
advancements
future
development
functional
peptide-based
delivery
both
domestically
internationally
recent
years,
expectation
achieving
incorporating
taking
full
advantage
synergistic
effects.
Abstract
Gene
therapy
provides
a
promising
strategy
for
curing
monogenetic
disorders
and
complex
diseases.
However,
there
are
challenges
associated
with
the
use
of
viral
delivery
vectors.
The
advent
nanomedicine
represents
quantum
leap
in
application
gene
therapy.
Recent
advances
stimulus‐responsive
nonviral
nanocarriers
indicate
that
they
efficient
systems
loading
unloading
therapeutic
nucleic
acids.
Some
responsive
to
cues
derived
from
internal
environment,
such
as
changes
pH,
redox
potential,
enzyme
activity,
reactive
oxygen
species,
adenosine
triphosphate,
hypoxia.
Others
external
stimulations,
including
temperature
gradients,
light
irradiation,
ultrasonic
energy,
magnetic
field.
Multiple
stimuli‐responsive
strategies
have
also
been
investigated
recently
experimental
Biomacromolecules,
Год журнала:
2021,
Номер
23(1), С. 1 - 19
Опубликована: Дек. 7, 2021
Bioresponsive
polymers
have
been
widely
used
in
drug
delivery
because
of
their
degradability.
For
example,
poly(disulfide)s
with
repeating
disulfide
bonds
the
main
chain
attracted
considerable
research
attention.
The
characteristics
bonds,
including
dynamic
and
reversible
properties
responsiveness
to
stimuli
such
as
reductants,
light,
heat,
mechanical
force,
make
them
ideal
platforms
for
on-demand
delivery.
This
review
introduces
synthesis
methods
applications
poly(disulfide)s.
Furthermore,
are
classified
on
basis
monomers
used:
oxidative
step-growth
polymerization
dithiols,
ring-opening
cyclic
disulfides,
linear
disulfides.
In
addition,
recent
advances
small-molecule
or
biomacromolecular
drugs
discussed.
Quantum-dot-loaded
poly(disulfide)
systems
imaging
also
included.
provides
an
overview
various
design
strategies
employed
construction
inspire
new
field
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2022,
Номер
395(12), С. 1477 - 1507
Опубликована: Сен. 15, 2022
Abstract
Blindness
affects
more
than
60
million
people
worldwide.
Retinal
disorders,
including
age-related
macular
degeneration
(AMD),
diabetic
retinopathy
(DR),
and
glaucoma,
are
the
leading
causes
of
blindness.
Finding
means
to
optimize
local
sustained
delivery
drugs
or
genes
eye
retina
is
one
goal
advance
development
new
therapeutics.
Despite
ease
accessibility
delivering
via
ocular
surface,
still
challenging
due
anatomic
physiologic
barriers.
Designing
a
suitable
platform
overcome
these
barriers
should
enhance
drug
bioavailability
provide
safe,
controlled,
release.
Current
inventions
for
posterior
segment
treatments
include
intravitreal
implants
subretinal
viral
gene
that
satisfy
criteria.
Several
other
novel
technologies,
nanoparticles,
micelles,
dendrimers,
microneedles,
liposomes,
nanowires,
now
being
widely
studied
delivery,
extensive
research
on
using
siRNA,
mRNA,
aptamers
also
rise.
This
review
discusses
current
state
retinal
drug/gene
highlights
future
therapeutic
opportunities.
Journal of Controlled Release,
Год журнала:
2022,
Номер
353, С. 518 - 534
Опубликована: Дек. 9, 2022
For
the
longest
time,
field
of
nucleic
acid
delivery
has
remained
skeptical
whether
or
not
polycationic
drug
carrier
systems
would
ever
make
it
into
clinical
practice.
Yet,
with
disclosure
patents
on
polyethyleneimine-based
RNA
carriers
through
leading
companies
in
therapeutics
such
as
BioNTech
SE
and
progress
studies
beyond
phase
I
trials,
this
aloofness
seems
to
regress.
As
one
most
striking
characteristics
polymer-based
vectors,
extraordinary
tunability
can
be
both
a
blessing
curse.
knowing
about
adjustment
screws
how
they
impact
performance
provides
formulation
scientist
committed
its
development
head
start.
Here,
we
equip
reader
toolbox
-
that
should
advise
support
developer
conceptualize
cutting-edge
poly-
micelleplex
system
for
therapeutic
acids;
specific,
engineer
vector
towards
maximum
endosomal
escape
at
minimum
toxicity.
Therefore,
after
briefly
sketching
boundary
conditions
polymeric
design,
will
dive
topic
trafficking.
We
only
discuss
recent
knowledge
endo-lysosomal
compartment
but
further
depict
different
hypotheses
mechanisms
facilitate
polyplex
systems.
Finally,
combine
facets
introduced
previous
chapters
fundamental
building
blocks
polymer
design
evaluate
advantages
drawbacks.
Throughout
article,
particular
focus
placed
cellular
peculiarities,
an
additional
barrier,
also
give
inspiration
cell-specific
traits
might
capitalized
on.
