Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game? DOI Open Access

Désirée Gül,

Burcu Önal Acet, Qiang Lü

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5171 - 5171

Опубликована: Май 9, 2024

Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively biological barriers. Smart designed/tuned nanostructures can be effective for cancer treatment. The selection design of adjustment size surface properties important, especially some precision treatments drug delivery (DD). By designing specific methods, an era opened in biomedical field personalized precise Here, we focus on advances nanostructures, as well how structure shape, size, charge, fluids (BFs) affected. We discussed applications specialized therapy head neck (HNC), which is a difficult aggressive type treat, give impetus novel treatment approaches this field. also comprehensively touched shortcomings, current trends, future perspectives when using cancer.

Язык: Английский

Emerging Applications of Nanotechnology in Healthcare and Medicine DOI Creative Commons
Shiza Malik, Khalid Muhammad, Yasir Waheed

и другие.

Molecules, Год журнала: 2023, Номер 28(18), С. 6624 - 6624

Опубликована: Сен. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Язык: Английский

Процитировано

232

Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics DOI
Dengshuai Wei, Yong Sun,

Hu Zhu

и другие.

ACS Nano, Год журнала: 2023, Номер 17(23), С. 23223 - 23261

Опубликована: Дек. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Язык: Английский

Процитировано

127

Exosomal circRNA: emerging insights into cancer progression and clinical application potential DOI Creative Commons
Fan Zhang, Jiajia Jiang, Hui Qian

и другие.

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Июнь 26, 2023

Abstract Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune fibroblasts, other components, thereby regulating critical aspects of cancer progression including escape, angiogenesis, metabolism, drug resistance, proliferation metastasis. Interestingly, microenvironment have new findings in influencing escape mediated by the release exosomal circRNA. Given intrinsic stability, abundance, broad distribution circRNAs, they represent excellent diagnostic prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up possibilities therapy, potentially bolstered nanoparticles or plant exosome delivery strategies. In this review, we summarize functions underlying mechanisms cell non-tumor cell-derived progression, with special focus on their roles immunity metabolism. Finally, examine potential application therapeutic targets, highlighting promise clinical use.

Язык: Английский

Процитировано

100

Nanoparticle drug delivery systems for synergistic delivery of tumor therapy DOI Creative Commons
Daoyuan Chen,

Xuecun Liu,

Xiaoyan Lu

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Фев. 16, 2023

Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not widely used in tumor therapy due to insufficient ability target specific sites, multidrug resistance drugs, and the high toxicity of drugs. With development RNAi technology, nucleic acids been delivered sites replace or correct defective genes knock down genes. Also, synergistic therapeutic effects can be achieved for combined delivery, which is more effective overcoming cancer cells. These combination therapies achieve better than delivering chemotherapeutic drugs alone, so scope has also expanded three aspects: drug-drug, drug-gene, gene-gene. This review summarizes recent advances nanocarriers co-delivery agents, including i) characterization preparation nanocarriers, such as lipid-based polymer inorganic carriers; ii) advantages disadvantages approaches; iii) effectual cases that applied systems; iv) future perspectives design nanoparticle co-deliver agents.

Язык: Английский

Процитировано

60

Advances in peptide-based drug delivery systems DOI Creative Commons

Sijie Guo,

Jing Wang, Qi Wang

и другие.

Heliyon, Год журнала: 2024, Номер 10(4), С. e26009 - e26009

Опубликована: Фев. 1, 2024

Drug-delivery systems (DDSs) are designed to deliver drugs their specific targets minimize toxic effects and improve susceptibility clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, adjustable molecular size; therefore, most peptides can be coupled via linkers form peptide-drug conjugates (PDCs) act as active pro-drugs. PDCs widely thought promising DDSs, given ability drug bio-compatibility physiological stability. Peptide-based DDSs often used therapeutic substances such anti-cancer nucleic acid-based drugs, which not only slow the degradation rate of in vivo but also ensure concentration at site prolong half-life vivo.This article provides an profile advancements future development functional peptide-based delivery both domestically internationally recent years, expectation achieving incorporating taking full advantage synergistic effects.

Язык: Английский

Процитировано

21

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy DOI
Yu Cheng, Long Li, Pei Hu

и другие.

Advanced Science, Год журнала: 2021, Номер 8(14)

Опубликована: Май 16, 2021

Abstract Gene therapy provides a promising strategy for curing monogenetic disorders and complex diseases. However, there are challenges associated with the use of viral delivery vectors. The advent nanomedicine represents quantum leap in application gene therapy. Recent advances stimulus‐responsive nonviral nanocarriers indicate that they efficient systems loading unloading therapeutic nucleic acids. Some responsive to cues derived from internal environment, such as changes pH, redox potential, enzyme activity, reactive oxygen species, adenosine triphosphate, hypoxia. Others external stimulations, including temperature gradients, light irradiation, ultrasonic energy, magnetic field. Multiple stimuli‐responsive strategies have also been investigated recently experimental

Язык: Английский

Процитировано

97

Poly(disulfide)s: From Synthesis to Drug Delivery DOI
Ruhe Zhang, Tianqi Nie,

Yifen Fang

и другие.

Biomacromolecules, Год журнала: 2021, Номер 23(1), С. 1 - 19

Опубликована: Дек. 7, 2021

Bioresponsive polymers have been widely used in drug delivery because of their degradability. For example, poly(disulfide)s with repeating disulfide bonds the main chain attracted considerable research attention. The characteristics bonds, including dynamic and reversible properties responsiveness to stimuli such as reductants, light, heat, mechanical force, make them ideal platforms for on-demand delivery. This review introduces synthesis methods applications poly(disulfide)s. Furthermore, are classified on basis monomers used: oxidative step-growth polymerization dithiols, ring-opening cyclic disulfides, linear disulfides. In addition, recent advances small-molecule or biomacromolecular drugs discussed. Quantum-dot-loaded poly(disulfide) systems imaging also included. provides an overview various design strategies employed construction inspire new field

Язык: Английский

Процитировано

73

Nanomedicine and drug delivery to the retina: current status and implications for gene therapy DOI Creative Commons
Mohamed M. Tawfik, Fang Chen, Jeffrey L. Goldberg

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2022, Номер 395(12), С. 1477 - 1507

Опубликована: Сен. 15, 2022

Abstract Blindness affects more than 60 million people worldwide. Retinal disorders, including age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, are the leading causes of blindness. Finding means to optimize local sustained delivery drugs or genes eye retina is one goal advance development new therapeutics. Despite ease accessibility delivering via ocular surface, still challenging due anatomic physiologic barriers. Designing a suitable platform overcome these barriers should enhance drug bioavailability provide safe, controlled, release. Current inventions for posterior segment treatments include intravitreal implants subretinal viral gene that satisfy criteria. Several other novel technologies, nanoparticles, micelles, dendrimers, microneedles, liposomes, nanowires, now being widely studied delivery, extensive research on using siRNA, mRNA, aptamers also rise. This review discusses current state retinal drug/gene highlights future therapeutic opportunities.

Язык: Английский

Процитировано

55

Engineering poly- and micelleplexes for nucleic acid delivery – A reflection on their endosomal escape DOI Creative Commons
Benjamin Winkeljann,

David C. Keul,

Olivia M. Merkel

и другие.

Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 518 - 534

Опубликована: Дек. 9, 2022

For the longest time, field of nucleic acid delivery has remained skeptical whether or not polycationic drug carrier systems would ever make it into clinical practice. Yet, with disclosure patents on polyethyleneimine-based RNA carriers through leading companies in therapeutics such as BioNTech SE and progress studies beyond phase I trials, this aloofness seems to regress. As one most striking characteristics polymer-based vectors, extraordinary tunability can be both a blessing curse. knowing about adjustment screws how they impact performance provides formulation scientist committed its development head start. Here, we equip reader toolbox - that should advise support developer conceptualize cutting-edge poly- micelleplex system for therapeutic acids; specific, engineer vector towards maximum endosomal escape at minimum toxicity. Therefore, after briefly sketching boundary conditions polymeric design, will dive topic trafficking. We only discuss recent knowledge endo-lysosomal compartment but further depict different hypotheses mechanisms facilitate polyplex systems. Finally, combine facets introduced previous chapters fundamental building blocks polymer design evaluate advantages drawbacks. Throughout article, particular focus placed cellular peculiarities, an additional barrier, also give inspiration cell-specific traits might capitalized on.

Язык: Английский

Процитировано

43

Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities DOI

Houman Isazadeh,

Farshid Oruji, Shima Shabani

и другие.

Molecular Biology Reports, Год журнала: 2023, Номер 50(11), С. 9529 - 9543

Опубликована: Сен. 23, 2023

Язык: Английский

Процитировано

37