Genes & Diseases,
Год журнала:
2023,
Номер
10(6), С. 2528 - 2539
Опубликована: Янв. 17, 2023
Bone
defects
caused
by
diseases
or
surgery
are
a
common
clinical
problem.
Researchers
devoted
to
finding
biological
mechanisms
that
accelerate
bone
defect
repair,
which
is
complex
and
continuous
process
controlled
many
factors.
As
members
of
transcriptional
costimulatory
molecules,
Yes-associated
protein
(YAP)
co-activator
with
PDZ-binding
motif
(TAZ)
play
an
important
regulatory
role
in
osteogenesis,
they
affect
cell
function
regulating
the
expression
osteogenic
genes
osteogenesis-related
cells.
Macrophages
group
cells
whose
regulated
YAP/TAZ.
Currently,
relationship
between
YAP/TAZ
macrophage
polarization
has
attracted
increasing
attention.
In
tissue,
can
realize
diverse
regulation
mediating
polarization.
polarize
into
M1
M2
phenotypes
under
different
stimuli.
macrophages
dominate
inflammatory
response
releasing
number
mediators
early
phase
while
massive
aggregation
beneficial
for
inflammation
resolution
tissue
as
secrete
anti-inflammatory
cytokines.
The
mechanism
YAP/TAZ-mediated
during
osteogenesis
warrants
further
study
it
likely
be
promising
strategy
repair.
this
article,
we
review
effect
Hippo-YAP/TAZ
signaling
on
highlight
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Дек. 8, 2021
During
tumor
growth
the
extracellular
matrix
(ECM)
undergoes
dramatic
remodeling.
The
normal
ECM
is
degraded
and
substituted
with
a
tumor-specific
ECM,
which
often
of
higher
collagen
density
increased
stiffness.
structure
has
been
associated
poor
prognosis
in
several
types
cancer.
However,
reason
for
this
association
still
largely
unknown.
Collagen
can
promote
cancer
cell
migration,
but
recent
studies
have
shown
that
collagens
also
affect
function
phenotype
various
tumor-infiltrating
immune
cells
such
as
tumor-associated
macrophages
(TAMs)
T
cells.
This
suggests
could
important
modulatory
functions
within
microenvironment,
affecting
progression
well
efficacy
immunotherapy.
effects
on
help
explain
why
high
tumors
correlated
prognosis.
Knowledge
about
potentially
identify
targets
improving
current
therapies
or
development
new
treatments.
In
review,
knowledge
ability
to
influence
activity
will
be
summarized.
includes
direct
interactions
induction
suppressive
other
macrophages.
Additionally,
potential
immunotherapy
discussed.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Янв. 25, 2022
Tissue
repair
after
trauma
and
infection
has
always
been
a
difficult
problem
in
regenerative
medicine.
Hydrogels
have
become
one
of
the
most
important
scaffolds
for
tissue
engineering
due
to
their
biocompatibility,
biodegradability
water
solubility.
Especially,
stiffness
hydrogels
is
key
factor,
which
influence
morphology
mesenchymal
stem
cells
(MSCs)
differentiation.
The
researches
on
this
point
are
meaningful
field
engineering.
Herein,
review
focus
design
with
different
effects
behavior
MSCs.
In
addition,
effect
hydrogel
phenotype
macrophages
introduced,
then
relationship
between
changes
inflammatory
response
discussed.
Finally,
future
application
certain
medicine
prospected.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(10)
Опубликована: Янв. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
Abstract
Cells
interact
with
their
surrounding
environment
through
a
combination
of
static
and
dynamic
mechanical
signals
that
vary
over
stimulus
types,
intensity,
space,
time.
Compared
to
such
as
stiffness,
porosity,
topography,
the
current
understanding
on
effects
stimulations
cells
remains
limited,
attributing
lack
access
devices,
complexity
experimental
set‐up,
data
interpretation.
Yet,
in
pursuit
emerging
translational
applications
(e.g.,
cell
manufacturing
for
clinical
treatment),
it
is
crucial
understand
how
respond
variety
forces
are
omnipresent
vivo
so
they
can
be
exploited
enhance
therapeutic
outcomes.
With
rising
appreciation
extracellular
matrix
(ECM)
key
regulator
biofunctions,
researchers
have
bioengineered
suite
ECM‐mimicking
hydrogels,
which
fine‐tuned
spatiotemporal
cues
model
complex
profiles.
This
review
first
discusses
stimuli
may
impact
different
cellular
components
various
mechanobiology
pathways
involved.
Then,
hydrogels
designed
incorporate
parameters
influence
behaviors
described.
The
Scopus
database
also
used
analyze
relative
strength
evidence,
ranging
from
strong
weak,
based
number
published
literatures,
associated
citations,
treatment
significance.
Additionally,
impacts
clinically
relevant
types
including
mesenchymal
stem
cells,
fibroblasts,
immune
evaluated.
aim
draw
attention
paucity
studies
well
highlight
potential
using
cocktail
intensities
fates
(similar
concept
biochemical
direct
fate).
It
envisioned
this
progress
report
will
inspire
more
exciting
development
mechanoresponsive
biomedical
applications.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 9, 2024
Biomaterial
wound
dressings,
such
as
hydrogels,
interact
with
host
cells
to
regulate
tissue
repair.
This
study
investigates
how
crosslinking
of
gelatin-based
hydrogels
influences
immune
and
stromal
cell
behavior
healing
in
female
mice.
We
observe
that
softer,
lightly
crosslinked
promote
greater
cellular
infiltration
result
smaller
scars
compared
stiffer,
heavily
hydrogels.
Using
single-cell
RNA
sequencing,
we
further
show
increase
inflammation
lead
the
formation
a
distinct
macrophage
subpopulation
exhibiting
signs
oxidative
activity
fusion.
Conversely,
are
more
readily
taken
up
by
macrophages
integrated
within
tissue.
The
physical
properties
differentially
affect
fibroblast
interactions,
promoting
pro-fibrotic
drives
fusion
through
RANKL
signaling.
These
findings
suggest
tuning
can
guide
responses
improve
healing,
offering
insights
for
designing
better
biomaterials
treatment.
Tissue-resident
macrophages
play
important
roles
in
tissue
homeostasis
and
repair.
However,
how
monitor
maintain
integrity
is
not
well
understood.
The
extracellular
matrix
(ECM)
a
key
structural
organizational
component
of
all
tissues.
Here,
we
find
that
sense
the
mechanical
properties
ECM
to
regulate
specific
repair
program.
We
show
macrophage
mechanosensing
mediated
by
cytoskeletal
remodeling
can
be
performed
three-dimensional
environments
through
noncanonical,
integrin-independent
mechanism
analogous
amoeboid
migration.
these
dynamics
also
integrate
biochemical
signaling
colony-stimulating
factor
1
ultimately
chromatin
accessibility
control
mechanosensitive
gene
expression
This
study
identifies
an
"amoeboid"
mode
which
may
fibrosis.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 21, 2024
The
extracellular
matrix
(ECM)
plays
critical
roles
in
cytoskeletal
support,
biomechanical
transduction
and
biochemical
signal
transformation.
Tumor-associated
macrophage
(TAM)
function
is
regulated
by
stiffness
solid
tumors
often
associated
with
poor
prognosis.
ECM
stiffness-induced
mechanical
cues
can
activate
cell
membrane
mechanoreceptors
corresponding
mechanotransducers
the
cytoplasm,
modulating
phenotype
of
TAMs.
Currently,
tuning
TAM
polarization
through
stimulation
has
received
increasing
attention,
whereas
its
effect
on
fate
rarely
been
summarized.
A
better
understanding
relationship
between
will
contribute
to
development
new
strategies
for
cancer
therapy.
In
this
review,
we
first
introduced
overall
stiffness,
analyzed
changes
mediated
tumor
progression,
finally
summarized
effects
targeting
prognosis
provide
insight
into
field.