Fibroblasts: Origins, definitions, and functions in health and disease

Cell, Год журнала: 2021, Номер 184(15), С. 3852 - 3872

Опубликована: Июль 1, 2021

Язык: Английский

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Tuning immunity through tissue mechanotransduction

Nature reviews. Immunology, Год журнала: 2022, Номер 23(3), С. 174 - 188

Опубликована: Авг. 16, 2022

Язык: Английский

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Immune Modulatory Properties of Collagen in Cancer

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Дек. 8, 2021

During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The normal ECM is degraded and substituted with a tumor-specific ECM, which often of higher collagen density increased stiffness. structure has been associated poor prognosis in several types cancer. However, reason for this association still largely unknown. Collagen can promote cancer cell migration, but recent studies have shown that collagens also affect function phenotype various tumor-infiltrating immune cells such as tumor-associated macrophages (TAMs) T cells. This suggests could important modulatory functions within microenvironment, affecting progression well efficacy immunotherapy. effects on help explain why high tumors correlated prognosis. Knowledge about potentially identify targets improving current therapies or development new treatments. In review, knowledge ability to influence activity will be summarized. includes direct interactions induction suppressive other macrophages. Additionally, potential immunotherapy discussed.

Язык: Английский

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A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Янв. 25, 2022

Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability water solubility. Especially, stiffness hydrogels is key factor, which influence morphology mesenchymal stem cells (MSCs) differentiation. The researches on this point are meaningful field engineering. Herein, review focus design with different effects behavior MSCs. In addition, effect hydrogel phenotype macrophages introduced, then relationship between changes inflammatory response discussed. Finally, future application certain medicine prospected.

Язык: Английский

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Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Advanced Functional Materials, Год журнала: 2023, Номер 33(10)

Опубликована: Янв. 1, 2023

Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.

Язык: Английский

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Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy

Advanced Science, Год журнала: 2023, Номер 10(21)

Опубликована: Апрель 29, 2023

Abstract Cells interact with their surrounding environment through a combination of static and dynamic mechanical signals that vary over stimulus types, intensity, space, time. Compared to such as stiffness, porosity, topography, the current understanding on effects stimulations cells remains limited, attributing lack access devices, complexity experimental set‐up, data interpretation. Yet, in pursuit emerging translational applications (e.g., cell manufacturing for clinical treatment), it is crucial understand how respond variety forces are omnipresent vivo so they can be exploited enhance therapeutic outcomes. With rising appreciation extracellular matrix (ECM) key regulator biofunctions, researchers have bioengineered suite ECM‐mimicking hydrogels, which fine‐tuned spatiotemporal cues model complex profiles. This review first discusses stimuli may impact different cellular components various mechanobiology pathways involved. Then, hydrogels designed incorporate parameters influence behaviors described. The Scopus database also used analyze relative strength evidence, ranging from strong weak, based number published literatures, associated citations, treatment significance. Additionally, impacts clinically relevant types including mesenchymal stem cells, fibroblasts, immune evaluated. aim draw attention paucity studies well highlight potential using cocktail intensities fates (similar concept biochemical direct fate). It envisioned this progress report will inspire more exciting development mechanoresponsive biomedical applications.

Язык: Английский

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Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 9, 2024

Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue repair. This study investigates how crosslinking of gelatin-based hydrogels influences immune and stromal cell behavior healing in female mice. We observe that softer, lightly crosslinked promote greater cellular infiltration result smaller scars compared stiffer, heavily hydrogels. Using single-cell RNA sequencing, we further show increase inflammation lead the formation a distinct macrophage subpopulation exhibiting signs oxidative activity fusion. Conversely, are more readily taken up by macrophages integrated within tissue. The physical properties differentially affect fibroblast interactions, promoting pro-fibrotic drives fusion through RANKL signaling. These findings suggest tuning can guide responses improve healing, offering insights for designing better biomaterials treatment.

Язык: Английский

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Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases

Nature Nanotechnology, Год журнала: 2024, Номер 19(3), С. 281 - 297

Опубликована: Янв. 29, 2024

Язык: Английский

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Mechanosensing regulates tissue repair program in macrophages

Science Advances, Год журнала: 2024, Номер 10(11)

Опубликована: Март 13, 2024

Tissue-resident macrophages play important roles in tissue homeostasis and repair. However, how monitor maintain integrity is not well understood. The extracellular matrix (ECM) a key structural organizational component of all tissues. Here, we find that sense the mechanical properties ECM to regulate specific repair program. We show macrophage mechanosensing mediated by cytoskeletal remodeling can be performed three-dimensional environments through noncanonical, integrin-independent mechanism analogous amoeboid migration. these dynamics also integrate biochemical signaling colony-stimulating factor 1 ultimately chromatin accessibility control mechanosensitive gene expression This study identifies an "amoeboid" mode which may fibrosis.

Язык: Английский

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Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 21, 2024

The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by stiffness solid tumors often associated with poor prognosis. ECM stiffness-induced mechanical cues can activate cell membrane mechanoreceptors corresponding mechanotransducers the cytoplasm, modulating phenotype of TAMs. Currently, tuning TAM polarization through stimulation has received increasing attention, whereas its effect on fate rarely been summarized. A better understanding relationship between will contribute to development new strategies for cancer therapy. In this review, we first introduced overall stiffness, analyzed changes mediated tumor progression, finally summarized effects targeting prognosis provide insight into field.

Язык: Английский

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