An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Год журнала: 2023, Номер 35(48)

Опубликована: Окт. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Язык: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15962 - 15977

Опубликована: Авг. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Язык: Английский

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An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Язык: Английский

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A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

ACS Materials Letters, Год журнала: 2024, Номер 6(7), С. 2533 - 2547

Опубликована: Май 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Язык: Английский

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Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

BMEMat, Год журнала: 2023, Номер 1(3)

Опубликована: Июнь 30, 2023

Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.

Язык: Английский

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Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Год журнала: 2023, Номер 52(17), С. 6191 - 6220

Опубликована: Янв. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Язык: Английский

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Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150756 - 150756

Опубликована: Март 26, 2024

Язык: Английский

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Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights

Burns & Trauma, Год журнала: 2024, Номер 12

Опубликована: Янв. 1, 2024

Abstract The healing process at a wound is made up of many types cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex changing ways. Microbial colonization proliferation are possible place injury, which makes infection more likely. Because this, any cut has chance getting an infection. Researchers have found that infections make patients upset cost healthcare system lot money. Surgical site happen to people who recently had surgery. This study shows such surgical linked high rate illness death. shown by fact 25% get serious sepsis need be transferred intensive care unit. In both animal models people, mesenchymal stem cells (MSCs) play active role stages positive effects. Exosomes one main things MSCs release. They effects similar those parent MSCs. Various effector proteins, messenger RNA microRNAs can transported vesicles control activity target cells. big impact on process. These results suggest using MSC-exosomes as new type cell-free therapy could better safer option than whole cell therapy. review mostly about how use parts help heal.

Язык: Английский

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Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing

Advanced Science, Год журнала: 2024, Номер 11(18)

Опубликована: Март 5, 2024

Abstract Regulation of excessive inflammation and impaired cell proliferation is crucial for healing diabetic wounds. Although plant‐to‐mammalian regulation offers effective approaches chronic wound management, the development a potent plant‐based therapeutic presents challenges. This study aims to validate efficacy turmeric‐derived nanoparticles (TDNPs) loaded with natural bioactive compounds. TDNPs can alleviate oxidative stress, promote fibroblast migration, reprogram macrophage polarization. Restoration fibroblast–macrophage communication network by stimulates cellular regeneration, in turn enhancing healing. To address are an ultralight‐weight, high swelling ratio, breathable aerogel (AG) constructed cellulose nanofibers sodium alginate backbones obtain TDNPs@AG (TAG). TAG features shape‐customized accessibility, water‐adaptable tissue adhesiveness, capacity sustained release TDNPs, exhibiting outstanding performance facilitating vivo highlights potential regenerative medicine their applicability as promising solution clinical settings.

Язык: Английский

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Mxene-based mild hyperthemia microneedle patch for diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148592 - 148592

Опубликована: Янв. 7, 2024

Язык: Английский

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