Magnetic sensitivity of cryptochrome 4 from a migratory songbird

Nature, Год журнала: 2021, Номер 594(7864), С. 535 - 540

Опубликована: Июнь 23, 2021

Язык: Английский

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Magnetic field effects in biology from the perspective of the radical pair mechanism

Journal of The Royal Society Interface, Год журнала: 2022, Номер 19(193)

Опубликована: Авг. 1, 2022

Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, energies implicated in effects are much smaller than thermal energies. Here, we review observations, and suggest an explanation based on radical pair mechanism, which involves quantum dynamics electron nuclear spins transient molecules. While mechanism has been studied detail context avian magnetoreception, reviewed here show magnetosensitivity is widespread throughout biology. We field physiological functions, discussing static, hypomagnetic oscillating fields, as well isotope effects. then a potential unifying model for described effects, discuss plausible candidate molecules pairs. recent proposing provides explanations xenon anaesthesia lithium treatment hyperactivity, circadian clock, neurogenesis microtubule assembly. conclude by future lines investigation this exciting new area

Язык: Английский

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Interactions between electromagnetic radiation and biological systems

iScience, Год журнала: 2024, Номер 27(3), С. 109201 - 109201

Опубликована: Фев. 10, 2024

Even though the bioeffects of electromagnetic radiation (EMR) have been extensively investigated during past several decades, our understandings EMR and mechanisms interactions between biological systems EMRs are still far from satisfactory. In this article, we introduce summarize consensus, controversy, limitations, unsolved issues. The published works effects on different including humans, animals, cells, biochemical reactions. Alternative methodologies also include dielectric spectroscopy, detection bioelectromagnetic emissions, theoretical predictions. many studies, thermal not properly controlled or considered. frequency is limited to commonly used bands, particularly frequencies power line wireless communications; fewer studies were performed for other frequencies. addition, complex EM environment rarely discussed. summary, understanding quite restrictive further investigations needed answer questions.

Язык: Английский

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Quantum life science: biological nano quantum sensors, quantum technology-based hyperpolarized MRI/NMR, quantum biology, and quantum biotechnology

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The emerging field of quantum life science combines principles from physics and biology to study fundamental processes at the molecular level.

Язык: Английский

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Approaching the Quantum Limit of Energy Resolution in Animal Magnetoreception

PRX Life, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 16, 2025

A large number of magnetic sensors, like superconducting quantum interference devices, optical pumping, and nitrogen vacancy magnetometers, were shown to satisfy the energy resolution limit. This limit states that sensitivity sensor, when translated into a product with time, is bounded below by Planck's constant, ℏ. bound implies fundamental limitation as what can be achieved in sensing. Here we explore biological particular three magnetoreception mechanisms thought underly animals' geomagnetic field sensing: radical-pair, magnetite, MagR mechanism. We address question how close these approach At quantitative level, utility it informs workings sensing model-independent ways thus provide subtle consistency checks for theoretical models estimated or measured parameter values, particularly needed complex systems. qualitative closer ℏ, more “quantum” sensor. offers an alternative route towards understanding biology magnetoreception. It also quantifies room improvement, illuminating nature has achieved, stimulating engineering biomimetic sensors exceeding nature's performance. Published American Physical Society 2025

Язык: Английский

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Adaptive evolution and loss of a putative magnetoreceptor in passerines

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 291(2016)

Опубликована: Фев. 7, 2024

Migratory birds possess remarkable accuracy in orientation and navigation, which involves various compass systems including the magnetic compass. Identifying primary magnetosensor remains a fundamental open question. Cryptochromes (Cry) have been shown to be magnetically sensitive, Cry4a from migratory songbird seems show enhanced sensitivity vitro compared resident species. We investigate Cry their potential involvement magnetoreception phylogenetic framework, integrating molecular evolutionary analyses with protein dynamics modelling. Our analysis is based on 363 bird genomes identifies different selection regimes passerines. that characterized by strong positive high variability, typical characteristics of sensor proteins. identify key sites are likely facilitated evolution an optimized sensory for night-time songbirds. Additionally, we Cry4 was lost hummingbirds, parrots Tyranni (Suboscines), thus identified gene deletion, might facilitate testing function birds. In contrast, other avian (Cry1 Cry2) were highly conserved across all species, indicating basal, non-sensory functions. results support specialization or functional differentiation songbirds could magnetosensation.

Язык: Английский

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Discovery of magnetic field line dependent anisotropic chemiresistive response in Magnetite: A new piece to the puzzle of magnetoreception

Materials Horizons, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The discovery of anisotropic chemiresistive properties in magnetite under an Earth-like magnetic field offers a crucial clue that may unravel the long-standing mystery behind physical mechanism magnetite-based magnetoreception.

Язык: Английский

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The Magnetic Compass of Birds: The Role of Cryptochrome

Frontiers in Physiology, Год журнала: 2021, Номер 12

Опубликована: Май 19, 2021

The geomagnetic field provides directional information for birds. avian magnetic compass is an inclination that uses not the polarity of but axial course lines and their in space. It works a flexible functional window, it requires short-wavelength light. These characteristics result from underlying sensory mechanism based on radical pair processes eyes, with cryptochrome suggested as receptor molecule. chromophore cryptochrome, flavin adenine dinucleotide (FAD), undergoes photocycle, where pairs are formed during photo-reduction well re-oxidation; behavioral data indicate latter crucial detecting directions. Five types cryptochromes found retina birds: 1a (Cry1a), 1b, 2, 4a, 4b. Because its location outer segments ultraviolet cones clear oil droplets, Cry1a appears to be most likely molecule information.

Язык: Английский

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Cryptochrome magnetoreception: four tryptophans could be better than three

Journal of The Royal Society Interface, Год журнала: 2021, Номер 18(184)

Опубликована: Ноя. 1, 2021

The biophysical mechanism of the magnetic compass sensor in migratory songbirds is thought to involve photo-induced radical pairs formed cryptochrome (Cry) flavoproteins located photoreceptor cells eyes. In Cry4a—the most likely six known avian Crys have a sensing function—four pair states are sequentially by stepwise transfer an electron along chain four tryptophan residues photo-excited flavin. purified Cry4a from European robin, third these flavin–tryptophan more magnetically sensitive than fourth, consistent with smaller separation radicals former. Here, we explore idea that two could exist rapid dynamic equilibrium such key and kinetic properties weighted averages. Spin dynamics simulations suggest largely responsible for while fourth may be better placed initiate signalling particularly if terminal can reduced nearby tyrosine. Such arrangement allowed independent optimization essential functions protein. It might also rationalize why has tryptophans plants only three.

Язык: Английский

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Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor

Journal of Comparative Physiology A, Год журнала: 2022, Номер 208(1), С. 97 - 106

Опубликована: Янв. 1, 2022

The light-dependent magnetic compass sense of night-migratory songbirds can be disrupted by weak radiofrequency fields. This finding supports a quantum mechanical, radical-pair-based mechanism magnetoreception as observed for isolated cryptochrome 4, protein found in birds' retinas. exact identity the magnetically sensitive radicals is uncertain vivo, but their formation seems to require bound flavin adenine dinucleotide chromophore and chain four tryptophan residues within protein. Resulting from hyperfine interactions nuclear spins with unpaired electrons, sensitivity fields depends strongly on number nuclei (hydrogen nitrogen atoms) they contain. Quantum-chemical calculations suggested that electromagnetic noise frequency range 75-85 MHz could give information about involved. Here, we show broadband prevent songbird using its behavioural experiments. These results indicate at least one components radical pair involved sensory process avian must contain substantial strong would case if flavin-tryptophan were sensor.

Язык: Английский

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