IL-4 as a potential biomarker for differentiating major depressive disorder from bipolar depression DOI Creative Commons

Lingna Lu,

Xiwen Hu, Xin Jin

и другие.

Medicine, Год журнала: 2023, Номер 102(15), С. e33439 - e33439

Опубликована: Апрель 14, 2023

We aimed to investigate the differential diagnosis of depressive episodes in patients with major disorder (MDD) and bipolar (BD) using peripheral blood cytokine expression levels. The levels interleukin (IL)-2, IL-6, IL-10, IL-17, IL4, IL-12; interferon (IFN)-γ; tumor necrosis factor (TNF)-α were measured MDD BD presenting acute an inpatient psychiatric setting. IFN-γ groups higher than those control group (P < .05), but there was no significant difference between patient group. Only TNF-α IL-4 both group, had .05). IFN-γ, significantly BD-related manic TNF-α, MDD-related receiver operating characteristic curve test for area under revealed good clinical predictability. Patients exhibited different profiles when experiencing episodes; a more severe immune-inflammatory response system-compensatory immunoregulatory system (CIRS) imbalance. found have diagnostic value differentiating active BD.

Язык: Английский

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression DOI Creative Commons
Haixia Wang, Yi He, Zuoli Sun

и другие.

Journal of Neuroinflammation, Год журнала: 2022, Номер 19(1)

Опубликована: Июнь 6, 2022

Abstract Major depressive disorder is a highly debilitating psychiatric involving the dysfunction of different cell types in brain. Microglia are predominant resident immune cells brain and exhibit critical role depression. Recent studies have suggested that depression can be regarded as microglial disease. regulate inflammation, synaptic plasticity, formation neural networks, all which affect In this review, we highlighted microglia pathology First, described activation animal models clinically depressed patients. Second, emphasized possible mechanisms by recognize depression-associated stress conditions. Third, how antidepressants (clinical medicines natural products) activation. Thus, review aimed to objectively analyze focus on potential antidepressants. These data regulation actions might novel therapeutic strategy counteract adverse effects devastating mental disorders.

Язык: Английский

Процитировано

300

Transforming the understanding of brain immunity DOI
Giulia Castellani, Tommaso Croese, Javier María Peralta Ramos

и другие.

Science, Год журнала: 2023, Номер 380(6640)

Опубликована: Апрель 6, 2023

Contemporary studies have completely changed the view of brain immunity from envisioning as isolated and inaccessible to peripheral immune cells an organ in close physical functional communication with system for its maintenance, function, repair. Circulating reside special niches brain's borders, choroid plexus, meninges, perivascular spaces, which they patrol sense a remote manner. These niches, together meningeal lymphatic skull microchannels, provide multiple routes interaction between system, addition blood vasculature. In this Review, we describe current ideas about their implications aging, diseases, immune-based therapeutic approaches.

Язык: Английский

Процитировано

181

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke DOI
Diana Alsbrook, Mario Di Napoli, Kunal Bhatia

и другие.

Current Neurology and Neuroscience Reports, Год журнала: 2023, Номер 23(8), С. 407 - 431

Опубликована: Июль 3, 2023

Язык: Английский

Процитировано

157

Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation? DOI Open Access
Stefan Harsanyi,

Ida Kupcová,

Ľuboš Danišovič

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 578 - 578

Опубликована: Дек. 29, 2022

Depression is one of the leading mental illnesses worldwide and lowers quality life many. According to WHO, about 5% population suffers from depression. Newer studies report a staggering global prevalence 27.6%, it rising. Professionally, depression belonging affective disorders psychiatric illness, category major depressive disorder (MDD) comprises various diagnoses related persistent disruptive mood disorders. Due this fact, imperative find way assess quantitatively using specific biomarker or panel biomarkers that would be able reflect patients' state effects therapy. Cytokines, hormones, oxidative stress markers, neuropeptides are studied in association with The latest research into inflammatory cytokines shows their relationship etiology causative. There stronger cytokine reactions pathogens stressors If combined other predisposing factors, responses lead prolonged processes, dysregulation axes, stress, pain, changes, anxiety, This review focuses on most recent data as markers concerning roles its pathogenesis, possible use diagnosis management, different levels bodily fluids, similarities animal studies. However, not isolated pathophysiologic mechanisms Their only part whole pathway.

Язык: Английский

Процитировано

149

The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases DOI
Mobina Amanollahi, Melika Jameie, Arash Heidari

и другие.

Molecular Neurobiology, Год журнала: 2022, Номер 60(2), С. 923 - 959

Опубликована: Ноя. 16, 2022

Язык: Английский

Процитировано

113

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis DOI Creative Commons
Anbiao Wu, Jiyan Zhang

Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Ноя. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Язык: Английский

Процитировано

85

Stress induced microglial activation contributes to depression DOI
Bingjin Li, Wei Yang, Tongtong Ge

и другие.

Pharmacological Research, Год журнала: 2022, Номер 179, С. 106145 - 106145

Опубликована: Фев. 24, 2022

Язык: Английский

Процитировано

84

Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance DOI Creative Commons
Evgenia Salta, Orly Lazarov, Carlos P. Fitzsimons

и другие.

Cell stem cell, Год журнала: 2023, Номер 30(2), С. 120 - 136

Опубликована: Фев. 1, 2023

Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, clinical data critically discuss the multicellular complexity niche relation to pathophysiology. further present roadmap toward better understanding role by probing promises caveats latest technological advancements field addressing conceptual methodological challenges ahead.

Язык: Английский

Процитировано

80

Engineered Nanoerythrocytes Alleviate Central Nervous System Inflammation by Regulating the Polarization of Inflammatory Microglia DOI
Na Yin,

Yuzhen Zhao,

Chang‐Hua Liu

и другие.

Advanced Materials, Год журнала: 2022, Номер 34(27)

Опубликована: Апрель 28, 2022

Microglial polarization is one of the most promising therapeutic strategies for multiple central nervous system (CNS) disorders. However, safe, effective, and controllable microglial regulation still faces formidable challenges. Although some anti-inflammatory factors promote microglia polarization, their short half-life, high cost, unpredictable in vivo behavior, complex delivery operations, hamper clinical application. Here, inspired by natural microhemorrhage cleaning mechanism, an MG1 peptide RVG29 engineered nanoerythrocyte (NEMR) that can reprogram are developed from classical M1 toward alternative M2 inducing heme oxygenase-1 (HO-1), stimulating Notch1/Hes1/Stat3 signaling, further inhibiting NF-κB p65 translocation. Moreover, carbon monoxide (CO) bilirubin produced endogenous metabolism reinforces effect. In middle cerebral artery occlusion experimental autoimmune encephalomyelitis models, a satisfactory prognosis achieved, with precise inflammatory lesion sites, increased expression factors, reduced blood-brain barrier permeability, as well promotion neurogenesis functional recovery. Furthermore, NEMR be integrated agents, which facilitates drug to enhance effects. Hence, nanoerythrocytes, feasible, efficient, practical tool, provides new strategy rebalancing immune environment CNS

Язык: Английский

Процитировано

79

The neuroimmunology of social-stress-induced sensitization DOI
Rebecca G. Biltz, Caroline M. Sawicki, John F. Sheridan

и другие.

Nature Immunology, Год журнала: 2022, Номер 23(11), С. 1527 - 1535

Опубликована: Ноя. 1, 2022

Язык: Английский

Процитировано

72