IL-4 as a potential biomarker for differentiating major depressive disorder from bipolar depression DOI Creative Commons

Lingna Lu,

Xiwen Hu, Xin Jin

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(15), P. e33439 - e33439

Published: April 14, 2023

We aimed to investigate the differential diagnosis of depressive episodes in patients with major disorder (MDD) and bipolar (BD) using peripheral blood cytokine expression levels. The levels interleukin (IL)-2, IL-6, IL-10, IL-17, IL4, IL-12; interferon (IFN)-γ; tumor necrosis factor (TNF)-α were measured MDD BD presenting acute an inpatient psychiatric setting. IFN-γ groups higher than those control group (P < .05), but there was no significant difference between patient group. Only TNF-α IL-4 both group, had .05). IFN-γ, significantly BD-related manic TNF-α, MDD-related receiver operating characteristic curve test for area under revealed good clinical predictability. Patients exhibited different profiles when experiencing episodes; a more severe immune-inflammatory response system-compensatory immunoregulatory system (CIRS) imbalance. found have diagnostic value differentiating active BD.

Language: Английский

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression DOI Creative Commons
Haixia Wang, Yi He, Zuoli Sun

et al.

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: June 6, 2022

Abstract Major depressive disorder is a highly debilitating psychiatric involving the dysfunction of different cell types in brain. Microglia are predominant resident immune cells brain and exhibit critical role depression. Recent studies have suggested that depression can be regarded as microglial disease. regulate inflammation, synaptic plasticity, formation neural networks, all which affect In this review, we highlighted microglia pathology First, described activation animal models clinically depressed patients. Second, emphasized possible mechanisms by recognize depression-associated stress conditions. Third, how antidepressants (clinical medicines natural products) activation. Thus, review aimed to objectively analyze focus on potential antidepressants. These data regulation actions might novel therapeutic strategy counteract adverse effects devastating mental disorders.

Language: Английский

Citations

299
Transforming the understanding of brain immunity DOI
Giulia Castellani, Tommaso Croese, Javier María Peralta Ramos

et al.

Science, Journal Year: 2023, Volume and Issue: 380(6640)

Published: April 6, 2023

Contemporary studies have completely changed the view of brain immunity from envisioning as isolated and inaccessible to peripheral immune cells an organ in close physical functional communication with system for its maintenance, function, repair. Circulating reside special niches brain's borders, choroid plexus, meninges, perivascular spaces, which they patrol sense a remote manner. These niches, together meningeal lymphatic skull microchannels, provide multiple routes interaction between system, addition blood vasculature. In this Review, we describe current ideas about their implications aging, diseases, immune-based therapeutic approaches.

Language: Английский

Citations

179
Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke DOI
Diana Alsbrook, Mario Di Napoli, Kunal Bhatia

et al.

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(8), P. 407 - 431

Published: July 3, 2023

Language: Английский

Citations

152
Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation? DOI Open Access
Stefan Harsanyi,

Ida Kupcová,

Ľuboš Danišovič

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 578 - 578

Published: Dec. 29, 2022

Depression is one of the leading mental illnesses worldwide and lowers quality life many. According to WHO, about 5% population suffers from depression. Newer studies report a staggering global prevalence 27.6%, it rising. Professionally, depression belonging affective disorders psychiatric illness, category major depressive disorder (MDD) comprises various diagnoses related persistent disruptive mood disorders. Due this fact, imperative find way assess quantitatively using specific biomarker or panel biomarkers that would be able reflect patients' state effects therapy. Cytokines, hormones, oxidative stress markers, neuropeptides are studied in association with The latest research into inflammatory cytokines shows their relationship etiology causative. There stronger cytokine reactions pathogens stressors If combined other predisposing factors, responses lead prolonged processes, dysregulation axes, stress, pain, changes, anxiety, This review focuses on most recent data as markers concerning roles its pathogenesis, possible use diagnosis management, different levels bodily fluids, similarities animal studies. However, not isolated pathophysiologic mechanisms Their only part whole pathway.

Language: Английский

Citations

148
The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases DOI
Mobina Amanollahi, Melika Jameie, Arash Heidari

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 60(2), P. 923 - 959

Published: Nov. 16, 2022

Language: Английский

Citations

110
Stress induced microglial activation contributes to depression DOI
Bingjin Li, Wei Yang, Tongtong Ge

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 179, P. 106145 - 106145

Published: Feb. 24, 2022

Language: Английский

Citations

84
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis DOI Creative Commons
Anbiao Wu, Jiyan Zhang

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Language: Английский

Citations

84
Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance DOI Creative Commons
Evgenia Salta, Orly Lazarov, Carlos P. Fitzsimons

et al.

Cell stem cell, Journal Year: 2023, Volume and Issue: 30(2), P. 120 - 136

Published: Feb. 1, 2023

Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, clinical data critically discuss the multicellular complexity niche relation to pathophysiology. further present roadmap toward better understanding role by probing promises caveats latest technological advancements field addressing conceptual methodological challenges ahead.

Language: Английский

Citations

80
Engineered Nanoerythrocytes Alleviate Central Nervous System Inflammation by Regulating the Polarization of Inflammatory Microglia DOI
Na Yin,

Yuzhen Zhao,

Chang‐Hua Liu

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(27)

Published: April 28, 2022

Microglial polarization is one of the most promising therapeutic strategies for multiple central nervous system (CNS) disorders. However, safe, effective, and controllable microglial regulation still faces formidable challenges. Although some anti-inflammatory factors promote microglia polarization, their short half-life, high cost, unpredictable in vivo behavior, complex delivery operations, hamper clinical application. Here, inspired by natural microhemorrhage cleaning mechanism, an MG1 peptide RVG29 engineered nanoerythrocyte (NEMR) that can reprogram are developed from classical M1 toward alternative M2 inducing heme oxygenase-1 (HO-1), stimulating Notch1/Hes1/Stat3 signaling, further inhibiting NF-κB p65 translocation. Moreover, carbon monoxide (CO) bilirubin produced endogenous metabolism reinforces effect. In middle cerebral artery occlusion experimental autoimmune encephalomyelitis models, a satisfactory prognosis achieved, with precise inflammatory lesion sites, increased expression factors, reduced blood-brain barrier permeability, as well promotion neurogenesis functional recovery. Furthermore, NEMR be integrated agents, which facilitates drug to enhance effects. Hence, nanoerythrocytes, feasible, efficient, practical tool, provides new strategy rebalancing immune environment CNS

Language: Английский

Citations

79
A richer and more diverse future for microglia phenotypes DOI Creative Commons
Jie Wang,

Wen‐Bin He,

Junlong Zhang

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(4), P. e14713 - e14713

Published: March 21, 2023

Microglia are the only resident innate immune cells derived from mesoderm in nerve tissue. They play a role development and maturation of central nervous system (CNS). mediate repair CNS injury participate endogenous response induced by various diseases exerting neuroprotective or neurotoxic effects. Traditionally, microglia considered to be resting state, M0 type, under physiological conditions. In this they perform surveillance constantly monitoring pathological responses CNS. undergo series morphological functional changes state eventually polarize into classically activated (M1) alternatively (M2). M1 release inflammatory factors toxic substances inhibit pathogens, while M2 exert effects promoting regeneration. However, recent years, view regarding M1/M2 polarization has gradually changed. According some researchers, phenomenon is not yet confirmed. The term used for simplified description its phenotype function. Other researchers believe that process rich diverse, consequently, classification method limitations. This conflict hinders academic community establishing more meaningful pathways terms, therefore, careful revision concept required. present article briefly reviews current consensus controversy microglial typing provide supporting materials objective understanding microglia.

Language: Английский

Citations

53