Integrative and Comparative Biology,
Год журнала:
2021,
Номер
61(3), С. 867 - 886
Опубликована: Июнь 8, 2021
Internal
state
profoundly
alters
perception
and
behavior.
For
example,
a
starved
fly
may
approach
consume
foods
that
it
would
otherwise
find
undesirable.
A
socially
engaged
newt
remain
in
the
presence
of
predator,
whereas
solitary
attempt
to
escape.
Yet,
definition
internal
is
fluid
ill-defined.
As
an
interdisciplinary
group
scholars
spanning
five
career
stages
(from
undergraduate
full
professor)
six
academic
institutions,
we
came
together
provide
operational
could
be
useful
understanding
behavior
function
nervous
systems,
at
timescales
relevant
individual.
In
this
perspective,
propose
define
through
integrative
framework
centered
on
dynamic
interconnected
communication
loops
within
between
body
brain.
This
informed
by
synthesis
historical
contemporary
paradigms
used
neurobiologists,
ethologists,
physiologists,
endocrinologists.
We
view
as
composed
both
spatially
distributed
networks
(body-brain
loops),
temporally
mechanisms
weave
neural
circuits,
physiology,
Given
wide
spatial
temporal
scales
which
operates-and
therefore
broad
range
defined-we
choose
anchor
our
body.
Here
focus
studies
highlight
body-to-brain
signaling;
represented
endocrine
signaling,
brain
sensory
signaling.
potentially
unites
disparate
often
scientists
grappling
with
body-brain
interactions.
invite
others
join
us
examine
approaches
question
assumptions
study
underlying
dynamics
state.
Frontiers in Behavioral Neuroscience,
Год журнала:
2022,
Номер
15
Опубликована: Янв. 6, 2022
Behavioral
flexibility
is
critical
to
survival.
Animals
must
adapt
their
behavioral
responses
based
on
changes
in
the
environmental
context,
internal
state,
or
experience.
Studies
Drosophila
melanogaster
have
provided
insight
into
neural
circuit
mechanisms
underlying
flexibility.
Here
we
discuss
how
behavior
modulated
by
and
learning.
We
describe
general
principles
of
organization
modulation
that
underlie
flexibility,
are
likely
extend
other
species.
Journal of Comparative Physiology A,
Год журнала:
2023,
Номер
209(4), С. 467 - 488
Опубликована: Янв. 20, 2023
Abstract
Using
odors
to
find
food
and
mates
is
one
of
the
most
ancient
highly
conserved
behaviors.
Arthropods
from
flies
moths
crabs
use
broadly
similar
strategies
navigate
toward
odor
sources—such
as
integrating
flow
information
with
information,
comparing
concentration
across
sensors,
over
time.
Because
arthropods
share
many
homologous
brain
structures—antennal
lobes
for
processing
olfactory
mechanosensors
flow,
mushroom
bodies
(or
hemi-ellipsoid
bodies)
associative
learning,
central
complexes
navigation,
it
likely
that
these
closely
related
behaviors
are
mediated
by
neural
circuits.
However,
differences
in
types
they
seek,
physics
dispersal,
locomotion
water,
air,
on
substrates
mean
circuits
must
have
adapted
generate
a
wide
diversity
odor-seeking
In
this
review,
we
discuss
common
specializations
observed
navigation
behavior
arthropods,
review
our
current
knowledge
about
subserving
behavior.
We
propose
comparative
study
arthropod
nervous
systems
may
provide
insight
into
how
set
basic
circuit
structures
has
diversified
different
environments.
Pain
hypersensitivity
arises
from
the
induction
of
plasticity
in
peripheral
and
spinal
somatosensory
neurons,
which
modifies
nociceptive
input
to
brain,
altering
pain
perception.
We
applied
longitudinal
calcium
imaging
dorsal
projection
neurons
determine
whether
how
representation
stimuli
anterolateral
tract,
principal
pathway
transmitting
signals
changes
between
distinct
states.
In
healthy
mice,
we
identified
stable
outputs
selective
for
cooling
or
warming
a
neuronal
ensemble
activated
by
noxious
thermal
mechanical
stimuli.
Induction
acute
sensitization
topical
capsaicin
transiently
re-tuned
output
encode
low-intensity
contrast,
nerve
injury
resulted
persistent
suppression
innocuous
coupled
with
activation
normally
silent
population
high-threshold
neurons.
These
results
demonstrate
differential
modulation
brain
during
neuropathic
Current Opinion in Neurobiology,
Год журнала:
2020,
Номер
65, С. 129 - 137
Опубликована: Ноя. 23, 2020
The
larva
of
Drosophila
melanogaster
is
emerging
as
a
powerful
model
system
for
comprehensive
brain-wide
understanding
the
circuit
implementation
neural
computations.
With
an
unprecedented
amount
tools
in
hand,
including
synaptic-resolution
connectomics,
whole-brain
imaging,
and
genetic
selective
targeting
single
neuron
types,
it
possible
to
dissect
which
circuits
computations
are
at
work
behind
behaviors
that
have
interesting
level
complexity.
Here
we
present
some
recent
advances
regarding
multisensory
integration,
learning,
action
selection
larva.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Июль 5, 2021
Abstract
Feeding
decisions
are
fundamental
to
survival,
and
decision
making
is
often
disrupted
in
disease.
Here,
we
show
that
neural
activity
a
small
population
of
neurons
projecting
the
fan-shaped
body
higher-order
central
brain
region
Drosophila
represents
food
choice
during
sensory
conflict.
We
found
deprived
flies
made
tradeoffs
between
appetitive
aversive
values
food.
identified
an
upstream
neuropeptidergic
dopaminergic
network
relays
internal
state
other
decision-relevant
information
specific
subset
neurons.
These
were
strongly
inhibited
by
taste
rejected
choice,
suggesting
they
encode
behavioral
choice.
Our
findings
reveal
responses
choices
determined
not
only
quality,
but
also
previous
experience
(including
outcome)
hunger
state,
which
integrated
before
relay
downstream
motor
circuits
for
implementation.
Journal of Neuroendocrinology,
Год журнала:
2024,
Номер
36(6)
Опубликована: Март 11, 2024
Abstract
Olfaction
is
the
most
ancient
sense
and
needed
for
food‐seeking,
danger
protection,
mating
survival.
It
often
first
sensory
modality
to
perceive
changes
in
external
environment,
before
sight,
taste
or
sound.
Odour
molecules
activate
olfactory
neurons
that
reside
on
epithelium
nasal
cavity,
which
transmits
this
odour‐specific
information
bulb
(OB),
where
it
relayed
higher
brain
regions
involved
perception
behaviour.
Besides
odour
processing,
recent
studies
suggest
OB
extends
its
function
into
regulation
of
food
intake
energy
balance.
Furthermore,
numerous
hormone
receptors
associated
with
appetite
metabolism
are
expressed
within
OB,
suggesting
a
neuroendocrine
role
outside
hypothalamus.
Olfactory
cues
important
promote
preparatory
behaviours
consumption,
such
as
enhancing
salivation.
In
addition,
altered
state
(fasting,
satiety
overnutrition)
can
change
processing
perception.
Similarly,
various
animal
models
human
pathologies
indicate
strong
link
between
impairment
metabolic
dysfunction.
Therefore,
understanding
nature
reciprocal
relationship
critical
understand
how
disorders
arise.
This
present
review
elaborates
connection
olfaction,
feeding
behaviour
will
shed
light
an
interface
internal
environments.
Elucidating
specific
mechanisms
by
signals
integrated
translated
responses
holds
promise
development
targeted
therapeutic
strategies
interventions
aimed
at
modulating
promoting
health.
Biology,
Год журнала:
2024,
Номер
13(2), С. 94 - 94
Опубликована: Фев. 2, 2024
Neural
networks
have
an
extensive
ability
to
change
in
response
environmental
stimuli.
This
flexibility
peaks
during
restricted
windows
of
time
early
life
called
critical
periods.
The
ubiquitous
occurrence
this
form
plasticity
across
sensory
modalities
and
phyla
speaks
the
importance
periods
for
proper
neural
development
function.
Extensive
investigation
into
visual
has
advanced
our
knowledge
molecular
events
key
processes
that
underlie
impact
early-life
experience
on
neuronal
plasticity.
However,
despite
olfaction
overall
survival
organism,
cellular
basis
olfactory
not
garnered
study
compared
Recent
work
providing
a
comprehensive
mapping
highly
organized
neuropil
its
turn
attracted
growing
interest
how
these
circuits
undergo
Here,
we
perform
comparative
review
fruit
flies
mice
provide
novel
insight
odor
exposure
shaping
highlighting
mechanisms
found
modalities.
