Towards a biologically annotated brain connectome

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(12), С. 747 - 760

Опубликована: Окт. 17, 2023

Язык: Английский

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A synergistic workspace for human consciousness revealed by Integrated Information Decomposition

eLife, Год журнала: 2023, Номер 12

Опубликована: Июль 25, 2023

How is the information-processing architecture of human brain organised, and how does its organisation support consciousness? Here, we combine network science a rigorous information-theoretic notion synergy to delineate ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. We find loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual empirical reconciliation between two prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory, while also advancing our understanding supports through information.

Язык: Английский

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A critical period plasticity framework for the sensorimotor–association axis of cortical neurodevelopment

Trends in Neurosciences, Год журнала: 2023, Номер 46(10), С. 847 - 862

Опубликована: Авг. 28, 2023

To understand human brain development it is necessary to describe not only the spatiotemporal patterns of neurodevelopment but also neurobiological mechanisms that underlie them. Human neuroimaging studies have provided evidence for a hierarchical sensorimotor-to-association (S–A) axis cortical neurodevelopment. Understanding biological this program using traditional approaches has been challenging. Animal models used identify periods enhanced experience-dependent plasticity – 'critical periods' progress along hierarchies and are governed by conserved set promote then restrict plasticity. In review we hypothesize S–A in humans partly driven cascading maturation critical period mechanisms. We how recent advances vivo provide promising path toward testing hypothesis linking signals derived from non-invasive imaging

Язык: Английский

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From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 150, С. 105193 - 105193

Опубликована: Апрель 21, 2023

The human brain exhibits complex interactions across micro, meso-, and macro-scale organisational principles. Recent synergistic multi-modal approaches have begun to link micro-scale information systems level dynamics, transcending hierarchies offering novel perspectives into the brain's function dysfunction. Specifically, distribution of properties (such as receptor density or gene expression) can be mapped onto measures from functional MRI provide neurobiological insights. Methodological enrich imaging analyses with molecular are rapidly evolving, several streams research having developed relatively independently, each unique potential explore trans-hierarchical functioning brain. Here, we address three principal - spatial correlation, molecular-enriched network, in-silico whole modelling a critical overview different sources information, how this utilised within fMRI data, merits pitfalls methodology, and, through use key examples, highlight their promise shed new light on domains neuroscientific inquiry.

Язык: Английский

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In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(23)

Опубликована: Май 30, 2024

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I remains unknown. Here, we noninvasively estimate a putative marker whole-cortex by fitting large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our generates realistic dynamics in the Human Connectome Project. Next, show estimated sensitive gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced changes are spatially consistent with positron emission tomography measurement receptor density. then investigate relationship between and neurodevelopment. find declines heterogeneously across cerebral cortex youth, greatest reduction occurring sensorimotor systems relative association systems. Importantly, among children same chronological age, lower (especially cortex) linked better cognitive performance. This result replicated North American (8.2 23.0 y old) Asian (7.2 7.9 cohorts, suggesting more mature indexes improved cognition normative development. Overall, findings open door studying how disrupted trajectories may lead dysfunction psychopathology emerges youth.

Язык: Английский

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Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease

Cell Reports, Год журнала: 2024, Номер 43(2), С. 113691 - 113691

Опубликована: Янв. 21, 2024

Amyloid-β (Aβ) and tau proteins accumulate within distinct neuronal systems in Alzheimer's disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ pathologies than others, gene expression may play a role. We study the association between brain-wide profiles regional vulnerability (gene-to-Aβ associations) (gene-to-tau by leveraging two large independent AD cohorts. identify susceptibility genes modules co-expression network with specifically related AD. In addition, we biochemical pathways associated gene-to-Aβ gene-to-tau associations. These findings explain discordance pathologies. Finally, propose an analytic framework, linking identified gene-to-pathology associations cognitive dysfunction at individual level, suggesting potential clinical implication of

Язык: Английский

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Excitation–Inhibition Balance, Neural Criticality, and Activities in Neuronal Circuits

The Neuroscientist, Год журнала: 2024, Номер unknown

Опубликована: Янв. 31, 2024

Neural activities in local circuits exhibit complex and multilevel dynamic features. Individual neurons spike irregularly, which is believed to originate from receiving balanced amounts of excitatory inhibitory inputs, known as the excitation–inhibition balance. The spatial-temporal cascades clustered neuronal spikes occur variable sizes durations, manifested neural avalanches with scale-free These may be explained by criticality hypothesis, posits that systems operate around transition between distinct states. Here, we summarize experimental evidence for underlying theory balance criticality. Furthermore, review recent studies excitatory–inhibitory networks synaptic kinetics a simple solution reconcile these two apparently theories single circuit model. This provides more unified understanding circuits, spontaneous stimulus-response dynamics.

Язык: Английский

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A network control theory pipeline for studying the dynamics of the structural connectome

Nature Protocols, Год журнала: 2024, Номер unknown

Опубликована: Июль 29, 2024

Язык: Английский

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A dynamic bifurcation mechanism explains cortex-wide neural correlates of conscious access

Cell Reports, Год журнала: 2025, Номер 44(3), С. 115372 - 115372

Опубликована: Март 1, 2025

Язык: Английский

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Imaging Transcriptomics of Brain Disorders

Biological Psychiatry Global Open Science, Год журнала: 2021, Номер 2(4), С. 319 - 331

Опубликована: Окт. 22, 2021

Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain structure and function in vivo, it has been used extensively to map the neural changes associated with various disorders. However, most techniques offer only indirect measures underlying pathological mechanisms. The recent development anatomically comprehensive gene expression atlases opened new opportunities studying transcriptional correlates noninvasively measured phenotypes, offering rich framework evaluating pathophysiological hypotheses putative Here, we provide an overview some fundamental methods imaging transcriptomics outline their application understanding disorders neurodevelopment, adulthood, neurodegeneration. Converging evidence indicates that spatial variations are linked normative during age-related maturation neurodegeneration part cell-specific markers expression. Transcriptional disorder-related phenotypes also transcriptionally dysregulated genes identified ex vivo analyses patient brains. Modeling studies demonstrate patterns involved regional vulnerability spread disease across brain. This growing body work supports utility testing about molecular mechanism driving disease-related macroscopic phenotypes.

Язык: Английский

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