Prefrontal Cortex subregions provide distinct visual and behavioral feedback modulation to the Primary Visual Cortex DOI Creative Commons
Sofie Ährlund‐Richter, Yuma Osako, Kyle Jenks

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Abstract The mammalian Prefrontal Cortex (PFC) has been suggested to modulate sensory information processing across multiple cortical regions via long-range axonal projections. These projections arise from PFC subregions with unique brain-wide connectivity and functional repertoires, which may provide the architecture for modular feedback intended shape processing. Here, we used tracing, somatic 2-photon calcium imaging, chemogenetic manipulations in mice delineate how Anterior Cingulate (ACA) ventrolateral Orbitofrontal (ORB) of primary Visual (VISp) behavioral states. Structurally, found that ACA ORB have distinct patterning both layers. axons VISp had a stronger representation visual stimulus than axons, but showed non-visual, behavior-dependent activity. input enhanced encoding stimuli by neurons, modulation responses scaled arousal. On other hand, shaped movement arousal related responses, specifically reduced high-contrast stimuli. Thus, separable projection patterns encode information, putatively providing substrate their effects on representations VISp. Our results offer refined model hierarchy its impact processing, whereby as opposed generalized properties contribute activity during discrete

Язык: Английский

The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques DOI Open Access
Amber Howell, Shaun Warrington, Clara Fonteneau

и другие.

Опубликована: Фев. 29, 2024

Each cortical area has a distinct pattern of anatomical connections within the thalamus, central subcortical structure composed functionally and structurally nuclei. Previous studies have suggested that certain areas may more extensive target multiple thalamic nuclei, which potentially allows them to modulate distributed information flow. However, there is lack quantitative investigations into connectivity patterns thalamus. Consequently, it remains unknown if exhibit systematic differences in extent their To address this knowledge gap, we used diffusion magnetic resonance imaging (dMRI) perform brain-wide probabilistic tractography for 828 healthy adults from Human Connectome Project. We then developed framework quantify spatial each area’s Additionally, leveraged resting-state functional MRI, myelin, human neural gene expression data test thalamus varied along hierarchy. Our results revealed two cortico-thalamic motifs: 1) sensorimotor motif characterized by focal targeting posterolateral associated with fast, feed-forward flow; 2) an associative diffuse anteromedial slow, feed-back These findings were consistent across subjects also observed macaques, indicating cross-species generalizability. Overall, our study demonstrates association support functionally-distinct

Язык: Английский

Процитировано

3
Dysfunctions of cellular context-sensitivity in neurodevelopmental learning disabilities DOI Creative Commons
Alberto Granato, William A. Phillips, Jan M. Schulz

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105688 - 105688

Опубликована: Апрель 25, 2024

Pyramidal neurons have a pivotal role in the cognitive capabilities of neocortex. Though they been predominantly modeled as integrate-and-fire point processors, many them another input integration their apical dendrites that is central to mechanisms endowing with sensitivity context underlies basic capabilities. Here we review evidence implicating impairments those three major neurodevelopmental disabilities, fragile X, Down syndrome, and fetal alcohol spectrum disorders. Multiple dysfunctions by which pyramidal cells are sensitive found be implicated all syndromes. Further deciphering these cellular would lead understanding therapies for learning disabilities beyond any currently available.

Язык: Английский

Процитировано

3
Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex DOI Creative Commons
Yuxiao Li, Miao Ren,

Bimin Liu

и другие.

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 15, 2025

The retrosplenial cortex (RSP) is a complex brain region with multiple interconnected subregions that plays crucial roles in various cognitive functions, including memory, spatial navigation, and emotion. Understanding the afferent efferent connectivity of RSP essential for comprehending underlying mechanisms its functions. Here, via viral tracing fluorescence micro-optical sectioning tomography (fMOST), we systematically investigated anatomical organisation upstream downstream circuits glutamatergic GABAergic neurons dorsal ventral RSP. cortical connections show laminar which input are distributed more deeper layers cortex. Although different types have similar circuits, bidirectional hippocampus, whereas only unidirectional connections. Moreover, receive inputs from primary sensory than prefrontal association preferred such exhibits spatially topological visual lateral thalamus. systematic study on long-range across cell may provide useful information future revealing working mechanisms. Dissection mouse intermediate reveals subregions.

Язык: Английский

Процитировано

0
Long‐range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse DOI Creative Commons
Miao Ren, Yuxiao Li, Tao Jiang

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Abstract INTRODUCTION Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, mechanisms underlying AD‐associated changes in long‐range circuits remain poorly understood. METHODS In this study, we used viral tracing and fluorescence micro‐optical sectioning tomography (fMOST) imaging investigate whole‐brain input circuit of frontal cortex 5×FAD mice. RESULTS Pathological axonal degeneration was widely observed upstream regions, including cortex, hippocampus, thalamus, across all AD brains examined. The proportion neurons projecting parvalbumin‐expressing neurons, compared those somatostatin‐expressing decreased hippocampus basal forebrain. This decline closely related mouse age cell type presynaptic neurons. DISCUSSION study demonstrates selective vulnerability prelimbic area at mesoscopic level, thereby enhancing our understanding architecture brain. Highlights We with single‐cell resolution generate brain‐wide maps model. pathological proportions showed relevance age, distribution, Compared body dendrites medial prefrontal structure are more extensive.

Язык: Английский

Процитировано

0
Deciphering neuronal variability across states reveals dynamic sensory encoding DOI Creative Commons
Shailaja Akella, Peter Ledochowitsch, Joshua H. Siegle

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0
Relationships and representations of brain structures, connectivity, dynamics and functions DOI
Oliver Schmitt

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111332 - 111332

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Remote synchronization induced by external signals in star networks DOI
Siyu Huo, Nan Yao,

Zi-Gang Huang

и другие.

Chaos Solitons & Fractals, Год журнала: 2025, Номер 196, С. 116345 - 116345

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

0
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation DOI
Ziru Deng, Xiang Fei, Siyu Zhang

и другие.

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Hippocampus alters visual representation to encode new memory DOI Creative Commons
Chenhui Liu, Zhen Liu,

Kaiyuan Liu

и другие.

Cell Reports, Год журнала: 2025, Номер 44(5), С. 115594 - 115594

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

0
Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes DOI Creative Commons
Zhaonan Chen, Yanmei Liu, Yunqi Yang

и другие.

Science Advances, Год журнала: 2025, Номер 11(22)

Опубликована: Май 30, 2025

Basal forebrain cholinergic neurons (BFCNs) influence cognition and emotion through specific acetylcholine release in various brain regions, including the prefrontal cortices basolateral amygdala (BLA). Acetylcholine is controlled by distinct BFCN subtypes, modulated excitatory inhibitory inputs. However, organization of whole-brain input-output networks these subtypes remains unclear. Here, we identified two subtypes—BFCN →ACA →BLA —innervating anterior cingulate cortex (ACA) BLA, each with unique distributions, electrophysiological properties, projection patterns. Combining rabies-virus–assisted mapping triple-plex RNAscope hybridization, characterized their input networks, identifying shared inputs for subtypes. Moreover, our results reveal a long-range reciprocal loop: target isocortex, excitatory-input source, whereas inhibitory-input sources such as striatum pallidum, thus enabling dynamic interactions among Our study deepens understanding modulation provides insights into functional interactions.

Язык: Английский

Процитировано

0