The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques DOI Open Access
Amber Howell, Shaun Warrington, Clara Fonteneau

et al.

Published: Feb. 29, 2024

Each cortical area has a distinct pattern of anatomical connections within the thalamus, central subcortical structure composed functionally and structurally nuclei. Previous studies have suggested that certain areas may more extensive target multiple thalamic nuclei, which potentially allows them to modulate distributed information flow. However, there is lack quantitative investigations into connectivity patterns thalamus. Consequently, it remains unknown if exhibit systematic differences in extent their To address this knowledge gap, we used diffusion magnetic resonance imaging (dMRI) perform brain-wide probabilistic tractography for 828 healthy adults from Human Connectome Project. We then developed framework quantify spatial each area’s Additionally, leveraged resting-state functional MRI, myelin, human neural gene expression data test thalamus varied along hierarchy. Our results revealed two cortico-thalamic motifs: 1) sensorimotor motif characterized by focal targeting posterolateral associated with fast, feed-forward flow; 2) an associative diffuse anteromedial slow, feed-back These findings were consistent across subjects also observed macaques, indicating cross-species generalizability. Overall, our study demonstrates association support functionally-distinct

Language: Английский

Deciphering neuronal variability across states reveals dynamic sensory encoding DOI Creative Commons
Shailaja Akella, Peter Ledochowitsch, Joshua H. Siegle

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 19, 2025

Language: Английский

Citations

0
Relationships and representations of brain structures, connectivity, dynamics and functions DOI
Oliver Schmitt

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111332 - 111332

Published: March 1, 2025

Language: Английский

Citations

0
Hippocampus alters visual representation to encode new memory DOI Creative Commons
Chenhui Liu, Zhen Liu,

Kaiyuan Liu

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115594 - 115594

Published: April 16, 2025

Language: Английский

Citations

0
The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques DOI Open Access
Amber Howell, Shaun Warrington, Clara Fonteneau

et al.

Published: Feb. 29, 2024

Each cortical area has a distinct pattern of anatomical connections within the thalamus, central subcortical structure composed functionally and structurally nuclei. Previous studies have suggested that certain areas may more extensive target multiple thalamic nuclei, which potentially allows them to modulate distributed information flow. However, there is lack quantitative investigations into connectivity patterns thalamus. Consequently, it remains unknown if exhibit systematic differences in extent their To address this knowledge gap, we used diffusion magnetic resonance imaging (dMRI) perform brain-wide probabilistic tractography for 828 healthy adults from Human Connectome Project. We then developed framework quantify spatial each area’s Additionally, leveraged resting-state functional MRI, myelin, human neural gene expression data test thalamus varied along hierarchy. Our results revealed two cortico-thalamic motifs: 1) sensorimotor motif characterized by focal targeting posterolateral associated with fast, feed-forward flow; 2) an associative diffuse anteromedial slow, feed-back These findings were consistent across subjects also observed macaques, indicating cross-species generalizability. Overall, our study demonstrates association support functionally-distinct

Language: Английский

Citations

3
Dysfunctions of cellular context-sensitivity in neurodevelopmental learning disabilities DOI Creative Commons
Alberto Granato, William A. Phillips, Jan M. Schulz

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105688 - 105688

Published: April 25, 2024

Pyramidal neurons have a pivotal role in the cognitive capabilities of neocortex. Though they been predominantly modeled as integrate-and-fire point processors, many them another input integration their apical dendrites that is central to mechanisms endowing with sensitivity context underlies basic capabilities. Here we review evidence implicating impairments those three major neurodevelopmental disabilities, fragile X, Down syndrome, and fetal alcohol spectrum disorders. Multiple dysfunctions by which pyramidal cells are sensitive found be implicated all syndromes. Further deciphering these cellular would lead understanding therapies for learning disabilities beyond any currently available.

Language: Английский

Citations

3
Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex DOI Creative Commons
Yanmei Liu, Jiahe Zhang,

Zhishan Jiang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 27, 2024

Abstract Unified visual perception requires integration of bottom-up and top-down inputs in the primary cortex (V1), yet organization V1 remains unclear. Here, we used optogenetics-assisted circuit mapping to identify how multiple from higher-order cortical thalamic areas engage excitatory inhibitory neurons. Top-down overlap superficial layers segregate deep layers. Inputs medial secondary (V2M) anterior cingulate (ACA) converge on L6 Pyrs, whereas ventrolateral orbitofrontal (ORBvl) lateral posterior nucleus (LP) are processed parallel Pyr-type-specific subnetworks (Pyr ←ORBvl Pyr ←LP ) drive mutual inhibition between them via local interneurons. Our study deepens understanding modulation mechanisms processing establishes that V2M ACA employ integrated distinct LP ORBvl L5.

Language: Английский

Citations

3
Remote synchronization induced by external signals in star networks DOI
Siyu Huo, Nan Yao,

Zi-Gang Huang

et al.

Chaos Solitons & Fractals, Journal Year: 2025, Volume and Issue: 196, P. 116345 - 116345

Published: April 3, 2025

Language: Английский

Citations

0
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation DOI
Ziru Deng, Xiang Fei, Siyu Zhang

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing DOI Creative Commons
Yanjie Wang,

Zhaonan Chen,

Guofen Ma

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 25, 2023

Abstract Interhemispheric communication through the corpus callosum is required for both sensory and cognitive processes. Impaired transcallosal inhibition causing interhemispheric imbalance believed to underlie visuospatial bias after frontoparietal cortical damage, but synaptic circuits involved remain largely unknown. Here, we show that lesions in mouse anterior cingulate area (ACA) cause severe mediated by a loop. In visual-change-detection task, ACA callosal-projection neurons (CPNs) were more active with contralateral visual field changes than ipsilateral changes. Unilateral CPN inactivation impaired change detection improved altering interaction callosal projections. CPNs strongly activated parvalbumin-positive (PV+) neurons, callosal-input-driven PV+ preferentially inhibited CPNs, thus mediating inhibition. neuron activation caused similar behavioral inactivation, bilateral eliminated this bias. Notably, restoring balance activating contralesional significantly ACA-lesioned animals. Thus, frontal loop comprising mediates processing, enhancing restores while also reversing lesion-induced

Language: Английский

Citations

8
The local and long‐range input landscape of inhibitory neurons in mouse auditory cortex DOI Creative Commons
Gen‐ichi Tasaka,

Claudia Maggi,

Elham Anwer Taha

et al.

The Journal of Comparative Neurology, Journal Year: 2022, Volume and Issue: 531(4), P. 502 - 514

Published: Dec. 1, 2022

Abstract Roughly 20% of the neurons in mouse cortex are inhibitory interneurons (INs). Of these, three major subtypes parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP) expressing neurons. We used monosynaptic rabies tracing to compare presynaptic input landscape onto these IN primary auditory (A1). compared both local patterns inputs as well long‐range patterns. The SST was more widespread PV VIP brain‐wide rich heterogeneous with >40 brain regions connecting all INs from hemispheres. general pattern similar among groups INs. Nevertheless, a few differences could be identified. At low resolution, proportion versus smaller for mesoscale we found fewer temporal association area INs, basal forebrain lateral amygdala. Our work can resource quantitative comparison location level impinging discrete populations A1.

Language: Английский

Citations

12