Technology Roadmap for Flexible Sensors

ACS Nano, Год журнала: 2023, Номер 17(6), С. 5211 - 5295

Опубликована: Март 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Язык: Английский

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Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues

Nature Materials, Год журнала: 2021, Номер 20(11), С. 1559 - 1570

Опубликована: Июль 29, 2021

Язык: Английский

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Three-dimensional electronic microfliers inspired by wind-dispersed seeds

Nature, Год журнала: 2021, Номер 597(7877), С. 503 - 510

Опубликована: Сен. 22, 2021

Язык: Английский

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Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

Frontiers in Science, Год журнала: 2023, Номер 1

Опубликована: Фев. 28, 2023

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning memory possibly cognition vitro . Coining the term “organoid intelligence” (OI) encompass these developments, we present a collaborative program implement vision multidisciplinary field OI. This aims establish OI as form genuine biological computing that harnesses using scientific bioengineering an ethically responsible manner. Standardized, 3D, myelinated can now be produced with high cell density enriched levels glial cells gene expression for learning. Integrated microfluidic perfusion systems support scalable durable culturing, spatiotemporal chemical signaling. Novel 3D microelectrode arrays permit high-resolution electrophysiological signaling recording explore capacity recapitulate mechanisms formation and, ultimately, their computational potential. Technologies could enable novel biocomputing models via stimulus-response training organoid-computer interfaces are development. We envisage complex, networked whereby connected real-world sensors output devices, ultimately each other sensory organ (e.g. retinal organoids), trained biofeedback, big-data warehousing, machine methods. In parallel, emphasize embedded ethics approach analyze ethical raised by research iterative, manner involving all relevant stakeholders. The many possible applications this urge strategic development discipline. anticipate OI-based allow faster decision-making, continuous during tasks, greater energy data efficiency. Furthermore, “intelligence-in-a-dish” help elucidate pathophysiology devastating developmental degenerative diseases (such dementia), potentially aiding identification therapeutic approaches address major global unmet needs.

Язык: Английский

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Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июль 29, 2022

Human brain organoids replicate much of the cellular diversity and developmental anatomy human brain. However, physiology neuronal circuits within remains under-explored. With high-density CMOS microelectrode arrays shank electrodes, we captured spontaneous extracellular activity from derived induced pluripotent stem cells. We inferred functional connectivity spike timing, revealing a large number weak connections skeleton significantly fewer strong connections. A benzodiazepine increased uniformity firing patterns decreased relative fraction weakly connected edges. Our analysis local field potential demonstrate that contain assemblies sufficient size to co-activate generate potentials their collective transmembrane currents phase-lock spiking activity. These results point for study neuropsychiatric diseases, drug action, effects external stimuli upon networks.

Язык: Английский

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Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare

Chemical Reviews, Год журнала: 2024, Номер 124(2), С. 455 - 553

Опубликована: Янв. 4, 2024

In the era of Internet-of-things, many things can stay connected; however, biological systems, including those necessary for human health, remain unable to connected global Internet due lack soft conformal biosensors. The fundamental challenge lies in fact that electronics and biology are distinct incompatible, as they based on different materials via functioning principles. particular, body is curvilinear, yet typically rigid planar. Recent advances design have generated tremendous opportunities wearable bioelectronics, which may bridge gap, enabling ultimate dream healthcare anyone, anytime, anywhere. We begin with a review historical development healthcare, indicating significant trend healthcare. This followed by focal point discussion about new design, particularly low-dimensional nanomaterials. summarize material types their attributes designing bioelectronic sensors; we also cover synthesis fabrication methods, top-down, bottom-up, combined approaches. Next, discuss energy challenges progress made date. addition front-end devices, describe back-end machine learning algorithms, artificial intelligence, telecommunication, software. Afterward, integration systems been applied various testbeds real-world settings, laboratories preclinical clinical environments. Finally, narrate remaining conjunction our perspectives.

Язык: Английский

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Shell microelectrode arrays (MEAs) for brain organoids

Science Advances, Год журнала: 2022, Номер 8(33)

Опубликована: Авг. 17, 2022

Brain organoids are important models for mimicking some three-dimensional (3D) cytoarchitectural and functional aspects of the brain. Multielectrode arrays (MEAs) that enable recording stimulation activity from electrogenic cells offer notable potential interrogating brain organoids. However, conventional MEAs, initially designed monolayer cultures, limited contact area restricted to bottom 3D Inspired by shape electroencephalography caps, we developed miniaturized wafer-integrated MEA caps The optically transparent shells composed self-folding polymer leaflets with conductive polymer–coated metal electrodes. Tunable folding minicaps’ guided mechanics simulations enables versatile different sizes, validate feasibility electrophysiology 400- 600-μm-sized up 4 weeks in response glutamate stimulation. Our studies suggest shell MEAs great high signal-to-noise ratio spatiotemporal organoid recording.

Язык: Английский

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Brain organoid reservoir computing for artificial intelligence

Nature Electronics, Год журнала: 2023, Номер 6(12), С. 1032 - 1039

Опубликована: Дек. 11, 2023

Язык: Английский

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Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain Organoids

Advanced Materials, Год журнала: 2022, Номер 34(11)

Опубликована: Янв. 11, 2022

Human induced pluripotent stem cell derived brain organoids have shown great potential for studies of human development and neurological disorders. However, quantifying the evolution electrical properties during is currently limited by measurement techniques, which cannot provide long-term stable 3D bioelectrical interfaces with developing organoids. Here, a cyborg organoid platform reported, in "tissue-like" stretchable mesh nanoelectronics are designed to match mechanical be folded organogenetic process progenitor or cells, distributing electrode arrays across The tissue-wide integrated show no interruption development, adapt volume morphological changes organogenesis, contacts neurons within development. seamless noninvasive coupling electrodes enables stable, continuous recording captures emergence single-cell action potentials from early-stage

Язык: Английский

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Assembly of complex 3D structures and electronics on curved surfaces

Science Advances, Год журнала: 2022, Номер 8(32)

Опубликована: Авг. 10, 2022

Electronic devices with engineered three-dimensional (3D) architectures are indispensable for frictional-force sensing, wide-field optical imaging, and flow velocity measurement. Recent advances in mechanically guided assembly established deterministic routes to 3D structures high-performance materials, through controlled rolling/folding/buckling deformations. The resulting are, however, mostly formed on planar substrates cannot be transferred directly onto another curved substrate. Here, we introduce an ordered strategy allow transformation of 2D thin films into sophisticated diverse surfaces. leverages predefined mechanical loadings that deform elastomer flat/cylindrical configurations, followed by additional uniaxial/biaxial prestretch drive buckling-guided assembly. Release results can accurately captured mechanics modeling, as illustrated dozens complex assembled substrates. Demonstrated applications include tunable dipole antennas, sensors inside a tube, integrated electronic systems capable conformal integration the heart.

Язык: Английский

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