Cell Reports Physical Science,
Год журнала:
2023,
Номер
4(6), С. 101444 - 101444
Опубликована: Май 31, 2023
Endosomal
escape
remains
a
well-known
bottleneck
for
successful
small
interfering
RNA
(siRNA)
therapeutics.
Here,
chemical
electron
transfer
(CET)-based
self-activatable
lipopolyplex
is
explored
producing
singlet
oxygen
(1O2)
in
endosomes,
thereby
enhancing
siRNA
delivery.
The
simultaneously
encapsulates
bis(2,4,6-trichlorophenyl)
oxalate
(TCPO),
gold
nanoparticles
(GNs),
and
siRNA.
GNs
are
specifically
self-activated
by
the
transferred
energy
between
TCPO
hydrogen
peroxide,
which
enhanced
tumor
microenvironment.
Enhanced
endosomal
membrane
damage
verified
using
cytosolic
fluorescent
galectin-8
(Gal8)-mRuby
reporter;
oxidation
of
1O2
facilitates
rupture
endosomes
within
4
h,
improving
recruitment
Gal8
to
disrupted
up
∼50-fold.
This
research
demonstrates
that
CET
can
facilitate
nucleic
acids
from
cytosol
provides
starting
point
further
delivery
applications.
Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Март 25, 2024
Abstract
Recombinant
adenovirus
(rAd)
regimens,
including
replication-competent
oncolytic
(OAV)
and
replication-deficient
adenovirus,
have
been
identified
as
potential
cancer
therapeutics.
OAV
presents
advantages
such
selective
replication,
efficacy,
tumor
microenvironment
(TME)
remodeling.
In
this
perspective,
the
principles
advancements
in
developing
toolkits
are
reviewed.
The
burgeoning
rAd
may
dictate
efficacy
of
conventional
therapies
well
immunotherapies,
vaccines,
synergy
with
adoptive
cell
therapy
(ACT),
TME
reshaping.
Concurrently,
we
explored
hitchhiking
to
immune
cells
or
stem
cells,
highlighting
how
approach
facilitates
synergistic
interactions
between
cellular
therapeutics
at
sites.
Results
from
preclinical
clinical
trials
which
were
infected
used
address
significant
oncological
challenges,
postsurgical
residual
tissue
metastatic
tissue.
Briefly,
can
eradicate
tumors
through
various
mechanisms,
resulting
immunogenicity,
reprogramming
TME,
enhancement
immunity,
effective
targeting.
context,
argue
that
holds
immense
for
enhancing
immunity
synergistically
improving
antitumor
effects
combination
novel
immunotherapies.
Tumor
immunotherapy,
which
utilizes
the
immune
system
to
fight
cancer,
represents
a
revolutionary
method
for
cancer
treatment.
Poly
(lactic-co-glycolic
acid)
(PLGA)
copolymer
has
emerged
as
promising
material
tumor
immunotherapy
due
its
biocompatibility,
biodegradability,
and
versatility
in
drug
delivery.
By
tuning
size,
shape,
surface
properties
of
PLGA-based
systems,
researchers
have
improved
their
ability
align
with
requirements
diverse
modalities.
In
this
review,
basic
PLGA
materials
are
first
introduced
further
principal
forms
systems
controlled
release
summarized
delivery
applications
targeted.
addition,
recent
advances
use
highlighted
enhance
antitumor
responses
terms
vaccines,
immunogenic
cell
death-mediated
responses,
microenvironment
modulation,
combination
immunotherapies.
Finally,
prospects
future
research
clinical
translation
proposed.
Heliyon,
Год журнала:
2024,
Номер
10(16), С. e35835 - e35835
Опубликована: Авг. 1, 2024
Highlights•Antifungal
drugs
and
their
resistance
development
mechanism
in
mycosis
infection.•Different
metabolic
path
for
potential
targets
of
antifungal
drugs.•The
elevated
risk
factors,
diagnosis
management
mycosis.•Complications
assessing
treatment
strategies
mycosis.•Updated
immune
therapeutics
mycosis.AbstractInfections
due
to
pathogenic
fungi
are
endemic
particular
area
with
increased
morbidity
mortality.
More
than
a
thousand
people
infected
per
year
the
way
is
high
demand
having
significant
impact
on
population
health.
Medical
practitioners
confront
various
troublesome
analytic
therapeutical
challenges
administration
immunosuppressed
sufferer
at
danger
expanding
fungal
infections.
An
upgraded
antimycosal
fundamental
fruitful
result
while
treating
intrusive
mycoses.
A
collection
keeps
developing
specific
including
cell
membrane,
mitochondria,
wall,
deoxyribonucleic
acid
(DNA)/ribonucleic
(RNA)
or
protein
biosynthesis.
Some
classes
ordinarily
directed
medications
polyenes,
amphotericin
B,
syringomycin,
allylamines,
honokiol,
azoles,
flucytosine,
echinocandins
etc.
However,
few
immunotherapy
processes
vaccinations
being
developed
mark
this
need,
although
one
presently
can't
seem
arrive
conclusion.
In
review
article,
there
has
been
trial
give
details
upgradation
about
current
therapeutic
techniques
vaccination
against
prevention
as
well
difficulties
related
turn
events.
There
also
visualization
mentioned
paper
assorted
target
analysis
along
interventions.Graphical
abstractGraphical
representation
immunotherapeutic
methods
mycosis.
Biomaterials Science,
Год журнала:
2024,
Номер
12(19), С. 4903 - 4926
Опубликована: Янв. 1, 2024
Nanoparticles
have
been
widely
developed
for
immune
regulation.
This
review
summarizes
the
effects
of
inorganic/organic
nanoparticles,
and
composite
nanoparticles
on
system
diseases.
