Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Depression
represents
a
prevalent
and
enduring
mental
disorder
of
significant
concern
within
the
clinical
domain.
Extensive
research
indicates
that
depression
is
very
complex,
with
many
interconnected
pathways
involved.
Most
related
to
focuses
on
monoamines,
neurotrophic
factors,
hypothalamic-pituitary-adrenal
axis,
tryptophan
metabolism,
energy
mitochondrial
function,
gut-brain
glial
cell-mediated
inflammation,
myelination,
homeostasis,
brain
neural
networks.
However,
recently,
Ketamine,
an
ionotropic
N-methyl-D-aspartate
(NMDA)
receptor
antagonist,
has
been
discovered
have
rapid
antidepressant
effects
in
patients,
leading
novel
successful
treatment
approaches
for
mood
disorders.
This
review
aims
summarize
latest
findings
insights
into
various
signaling
systems
observed
patients
animal
models,
providing
more
comprehensive
view
neurobiology
anxious-depressive-like
behavior.
Specifically,
it
highlights
key
mechanisms
ketamine
as
rapid-acting
antidepressant,
aiming
enhance
neuropsychiatric
Moreover,
we
discuss
potential
prophylactic
or
therapeutic
intervention
stress-related
psychiatric
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(9), С. 3856 - 3873
Опубликована: Сен. 1, 2023
Astrocytes
play
crucial
roles
in
brain
homeostasis
and
are
regulatory
elements
of
neuronal
synaptic
physiology.
Astrocytic
alterations
have
been
found
Major
Depressive
Disorder
(MDD)
patients;
however,
the
consequences
astrocyte
Ca2+
signaling
MDD
poorly
understood.
Here,
we
that
corticosterone-treated
juvenile
mice
(Cort-mice)
showed
altered
astrocytic
dynamics
mPFC
both
resting
conditions
during
social
interactions,
line
with
behavior.
Additionally,
Cort-mice
displayed
reduced
serotonin
(5-HT)-mediated
astrocytes,
aberrant
5-HT-driven
plasticity
layer
2/3
neurons.
Downregulation
naïve
animals
mimicked
deficits
Cort-mice.
Remarkably,
boosting
Gq-DREADDS
restored
to
control
levels
mood
cognitive
abilities
This
study
highlights
important
role
for
homeostatic
circuits
behavior,
but
also
reveals
its
potential
therapeutic
value
depressive-like
states.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Post-stroke
depression
(PSD),
a
frequent
and
disabling
complication
of
stroke,
has
strong
impact
on
almost
thirty
percent
stroke
survivors.
The
pathogenesis
PSD
is
not
completely
clear
so
far.
Neuroinflammation
following
one
underlying
mechanisms
that
involves
in
the
pathophysiology
plays
an
important
function
development
regarded
as
sign
depression.
During
neuroinflammation
after
ischemic
onset,
both
astrocytes
microglia
undergo
series
morphological
functional
changes
play
pro-inflammatory
or
anti-inflammatory
effect
pathological
process
stroke.
Importantly,
exert
dual
roles
due
to
phenotypic
transformation.
We
summarize
latest
evidence
involving
this
review,
focus
transformation
reveal
via
modulating
neuroinflammation.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Hydrogels
are
emerging
as
promising
candidates
for
brain–computer
interfaces.
This
review
highlights
the
current
advancements
in
implantable
hydrogel
electrodes
neural
signal
recording,
neuromodulation,
and
brain
disorder
treatment.
Trends in Neurosciences,
Год журнала:
2023,
Номер
46(6), С. 418 - 425
Опубликована: Март 30, 2023
The
integration
of
external
information
with
the
internal
state
body
is
central
to
survival
virtually
every
multicellular
organism.
However,
a
complete
picture
mechanisms
that
govern
this
process
lacking.
In
opinion
article,
we
synthesize
evidence
demonstrating
astrocytes
sense
momentary
arousal
-
through
neuromodulator
release
as
well
sensory
inputs
local
synaptic
activity
and
respond
them
changes
in
calcium
(Ca
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(2)
Опубликована: Фев. 1, 2024
Depression
is
a
prevalent
psychiatric
disorder
with
high
long-term
morbidities,
recurrences,
and
mortalities.
Despite
extensive
research
efforts
spanning
decades,
the
cellular
molecular
mechanisms
of
depression
remain
largely
unknown.
What's
more,
about
one
third
patients
do
not
have
effective
anti-depressant
therapies,
so
there
an
urgent
need
to
uncover
more
guide
development
novel
therapeutic
strategies.
Adenosine
triphosphate
(ATP)
plays
important
role
in
maintaining
ion
gradients
essential
for
neuronal
activities,
as
well
transport
release
neurotransmitters.
Additionally,
ATP
could
also
participate
signaling
pathways
following
activation
postsynaptic
receptors.
By
searching
website
PubMed
articles
"ATP
depression"
especially
focusing
on
extracellular
(eATP)
last
5
years,
we
found
that
numerous
studies
implied
insufficient
from
astrocytes
lead
exogenous
supply
eATP
or
endogenously
stimulating
alleviate
depression,
highlighting
potential
alleviating
depression.
Biomolecules,
Год журнала:
2024,
Номер
14(10), С. 1204 - 1204
Опубликована: Сен. 25, 2024
Astrocytes
are
one
of
the
key
glial
types
central
nervous
system
(CNS),
accounting
for
over
20%
total
cells
in
brain.
Extensive
evidence
has
established
their
indispensable
functions
maintenance
CNS
homeostasis,
as
well
broad
involvement
neurological
conditions.
In
particular,
astrocytes
can
participate
various
neuroinflammatory
processes,
e.g.,
releasing
a
repertoire
cytokines
and
chemokines
or
specific
neurotrophic
factors,
which
result
both
beneficial
detrimental
effects.
It
become
increasingly
clear
that
such
astrocyte-mediated
neuroinflammation,
together
with
its
complex
crosstalk
other
immune
cells,
designates
neuronal
survival
functional
integrity
neurocircuits,
thus
critically
contributing
to
disease
onset
progression.
this
review,
we
focus
on
current
knowledge
responses
astrocytes,
summarizing
common
features
Moreover,
highlight
several
vital
questions
future
research
promise
novel
insights
into
diagnostic
therapeutic
strategies
against
those
debilitating
diseases.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Abstract
Lysosomes
are
important
cellular
structures
for
human
health
as
centers
recycling,
signaling,
metabolism
and
stress
adaptation.
However,
the
potential
role
of
lysosomes
in
stress‐related
emotions
has
long
been
overlooked.
Here,
it
is
found
that
lysosomal
morphology
astrocytes
altered
medial
prefrontal
cortex
(mPFC)
susceptible
mice
after
chronic
social
defeat
stress.
A
screen
lysosome‐related
genes
revealed
expression
mucolipin
1
gene
(
Mcoln1
;
protein:
TRP
channel
1)
decreased
depressed
patients.
Astrocyte‐specific
knockout
(TRPML1)
induced
depressive‐like
behaviors
by
inhibiting
exocytosis‐mediated
adenosine
5′‐triphosphate
(ATP)
release.
Furthermore,
this
response
astrocytic
mediated
transcription
factor
EB
(TFEB),
overexpression
TRPML1
rescued
astrocyte‐specific
TFEB.
Collectively,
these
findings
reveal
a
stress‐sensing
signaling
pathway
contributing
to
development
depression
identify
lysosome
target
organelle
antidepressants.
