Different
from
the
direct
delivery
of
chemodynamic
agents
into
tumor
tissue
for
therapy
(CDT),
this
work
reports
fabrication
heterojunction
sonosensitizers
(CD/TiSe
2
)
in
situ
generation
by
responding
to
microenvironment
(TME),
realizing
CDT‐enhanced
sono‐immunotherapy.
The
redox
TiSe
acidic
TME
leads
formation
TiO
x
Se
2−
containing
(0),
selenate,
and
Ti
3+
/Ti
4+
couple,
which
can
facilitate
CDT
through
a
‐mediated
Fenton‐like
reaction
consume
overexpressed
glutathione
(GSH)
via
GSH
depletion.
Moreover,
ions
generated
process
promote
maturation
dendritic
cells,
consequently
activating
adaptive
immune
responses.
In
another
aspect,
construction
heterojunctions
within
carbon
dots
improves
reactive
oxygen
species
(ROS)
efficiency
cascaded
manner,
enhances
sonodynamic
activity
amplifies
performance.
More
importantly,
ROS
produced
efficiently
triggers
immunogenic
cell
death
synergistic
based
on
elicitation
antitumor
immunity
with
aid
an
checkpoint
blockade.
This
thus
provides
distinct
paradigm
transition
metal
selenide‐originated
agent
Advanced Materials,
Год журнала:
2023,
Номер
36(4)
Опубликована: Окт. 23, 2023
Abstract
Microwave
absorption
materials
(MAMs)
are
originally
developed
for
military
purposes,
but
have
since
evolved
into
versatile
with
promising
applications
in
modern
technologies,
including
household
use.
Despite
significant
progress
bench‐side
research
over
the
past
decade,
MAMs
remain
limited
their
scope
and
yet
to
be
widely
adopted.
This
review
explores
history
of
from
first‐generation
coatings
second‐generation
functional
absorbers,
identifies
bottlenecks
hindering
maturation.
It
also
presents
potential
solutions
such
as
exploring
broader
spatial
scales,
advanced
characterization,
introducing
liquid
media,
utilizing
novel
toolbox
(machine
learning,
ML),
proximity
lab
end‐user.
Additionally,
it
meticulously
compelling
medicine,
mechanics,
energy,
optics,
sensing,
which
go
beyond
efficiency,
along
current
development
status
prospects.
interdisciplinary
direction
differs
previous
primarily
focused
on
meeting
traditional
requirements
(i.e.,
thin,
lightweight,
wide,
strong),
can
defined
next
generation
smart
absorbers.
Ultimately,
effective
utilization
ubiquitous
electromagnetic
(EM)
waves,
aided
by
third‐generation
MAMs,
should
better
aligned
future
expectations.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 7326 - 7378
Опубликована: Март 13, 2023
Cancer
thermal
therapy,
also
known
as
hyperthermia
has
long
been
exploited
to
eradicate
mass
lesions
that
are
now
defined
cancer.
With
the
development
of
corresponding
technologies
and
equipment,
local
therapies
such
radiofrequency
ablation,
microwave
high-intensity
focused
ultrasound,
have
validated
effectively
ablate
tumors
in
modern
clinical
practice.
However,
they
still
face
many
shortcomings,
including
nonspecific
damages
adjacent
normal
tissues
incomplete
ablation
particularly
for
large
tumors,
restricting
their
wide
usage.
Attributed
versatile
physiochemical
properties,
biomaterials
specially
designed
potentiate
treatments
according
unique
working
principles.
Meanwhile,
biomaterial-based
delivery
systems
able
bridge
with
other
types
treatment
strategies
chemotherapy,
radiotherapy
immunotherapy.
Therefore,
this
review,
we
discuss
recent
progress
functional
reinforce
by
functioning
sensitizers
endow
more
efficient
tumor-localized
and/or
vehicles
synergize
therapeutic
modalities
combined
cancer
treatments.
Thereafter,
provide
a
critical
perspective
on
further
biomaterial-assisted
toward
applications.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(9)
Опубликована: Янв. 2, 2023
Oxygen-deficient
molybdenum
oxide
(MoOX
)
nanomaterials
are
prepared
as
novel
nanosensitizers
and
TME-stimulants
for
ultrasound
(US)-enhanced
cancer
metalloimmunotherapy.
After
PEGylation,
MoOX
-PEG
exhibits
efficient
capability
US-triggered
reactive
oxygen
species
(ROS)
generation
glutathione
(GSH)
depletion.
Under
US
irradiation,
generates
a
massive
amount
of
ROS
to
induce
cell
damage
immunogenic
death
(ICD),
which
can
effectively
suppress
tumor
growth.
More
importantly,
itself
further
stimulates
the
maturation
dendritic
cells
(DCs)
triggeres
activation
cGAS-STING
pathway
enhance
immunological
effect.
Due
robust
ICD
induced
by
SDT
DC
stimulated
-PEG,
combination
treatment
-triggered
aCTLA-4
amplifies
antitumor
therapy,
inhibits
metastases,
elicits
immune
responses
defeat
abscopal
tumors.
Dendritic
cell
(DC)-based
cancer
immunotherapy
has
exhibited
remarkable
clinical
prospects
because
DCs
play
a
central
role
in
initiating
and
regulating
adaptive
immune
responses.
However,
the
application
of
traditional
DC-mediated
is
limited
due
to
insufficient
antigen
delivery,
inadequate
presentation,
high
levels
immunosuppression.
To
address
these
challenges,
engineered
biomaterials
have
been
exploited
enhance
immunotherapeutic
effects.
In
this
review,
vital
principal
components
that
can
effects
are
first
introduced.
The
parameters
considered
rational
design
biomaterials,
including
targeting
modifications,
size,
shape,
surface,
mechanical
properties,
which
affect
biomaterial
optimization
DC
functions,
further
summarized.
Moreover,
recent
applications
various
field
reviewed,
those
serve
as
component
delivery
platforms,
remodel
tumor
microenvironment,
synergistically
other
antitumor
therapies.
Overall,
present
review
comprehensively
systematically
summarizes
related
promotion
functions;
specifically
focuses
on
advances
designs
for
activation
eradicate
tumors.
challenges
opportunities
treatment
strategies
designed
amplify
via
discussed
with
aim
inspiring
translation
future
immunotherapies.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 16, 2024
Immunotherapy
represents
a
revolutionary
paradigm
in
cancer
management,
showcasing
its
potential
to
impede
tumor
metastasis
and
recurrence.
Nonetheless,
challenges
including
limited
therapeutic
efficacy
severe
immune-related
side
effects
are
frequently
encountered,
especially
solid
tumors.
Hydrogels,
class
of
versatile
materials
featuring
well-hydrated
structures
widely
used
biomedicine,
offer
promising
platform
for
encapsulating
releasing
small
molecule
drugs,
biomacromolecules,
cells
controlled
manner.
Immunomodulatory
hydrogels
present
unique
capability
augmenting
immune
activation
mitigating
systemic
toxicity
through
encapsulation
multiple
components
localized
administration.
Notably,
based
on
biopolymers
have
gained
significant
interest
owing
their
biocompatibility,
environmental
friendliness,
ease
production.
This
review
delves
into
the
recent
advances
bio-based
immunotherapy
synergistic
combinatorial
approaches,
highlighting
diverse
applications.
It
is
anticipated
that
this
will
guide
rational
design
field
immunotherapy,
fostering
clinical
translation
ultimately
benefiting
patients.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Янв. 19, 2023
The
slightest
change
in
the
extra/intracellular
concentration
of
metal
ions
results
amplified
effects
by
signaling
cascades
that
regulate
both
cell
fate
within
tumor
microenvironment
and
immune
status,
which
influences
network
antitumor
immunity
through
various
pathways.
Based
on
fact
influence
cancer
cells
participate
innate
adaptive
immunity,
they
are
widely
applied
therapy
as
modulators.
Moreover,
nanomedicine
possesses
advantage
precise
delivery
responsive
release,
can
perfectly
remedy
drawbacks
ions,
such
low
target
selectivity
systematic
toxicity,
thus
providing
an
ideal
platform
for
ion
application
treatment.
Emerging
evidence
has
shown
immunotherapy
with
nanometallic
materials
may
significantly
enhance
therapeutic
efficacy.
Here,
we
focus
physiopathology
tumorigenesis
discuss
several
breakthroughs
regarding
use
immunotherapeutics.
These
findings
demonstrate
prominence
ion-based
prophylaxis,
many
new
ideas
basic
research
clinical
application.
Consequently,
provide
innovative
insights
into
comprehensive
understanding
combined
past
few
years.
