Nanoscale, Год журнала: 2024, Номер 16(21), С. 10208 - 10220
Опубликована: Янв. 1, 2024
Dendrimers and dendritic NPs are emerging as potential nanoplatforms for cancer immunotherapy. This minireview provides an updated overview of dendrimer conjugates, hybrids, dendron-based copolymers targeted therapy.
Язык: Английский
Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101277 - 101277
Опубликована: Март 8, 2024
The use of biomedical metallic materials in research and clinical applications has been an important focus a significant area interest, primarily owing to their role enhancing human health extending lifespan. This article, particularly on titanium-based alloys, explores exceptional properties that can address bone issues amid the growing challenges posed by aging population. Although stainless steel, magnesium-based cobalt-based other are commonly employed medical applications, limitations such as toxic elements, high elastic modulus, rapid degradation rates limit widespread applications. Therefore, alloys have emerged top-performing materials, gradually replacing counterparts various article extensively examines highlights along with in-depth discussion currently utilized inherent limitations. To begin with, essential requirements for load-bearing biomaterials introduced. Then, summarized compared. Afterward, microstructure, properties, preparations explored. Furthermore, surface modification methods discussed enhance biocompatibility, wear resistance corrosion resistance. Finally, proposes development path conjunction additive manufacturing novel alloy nitinol.
Язык: Английский
Процитировано
76
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Язык: Английский
Процитировано
2
Acta Biomaterialia, Год журнала: 2024, Номер 176, С. 51 - 76
Опубликована: Янв. 17, 2024
Язык: Английский
Процитировано
11
Polymer Composites, Год журнала: 2024, Номер unknown
Опубликована: Сен. 15, 2024
Abstract Carbon fiber reinforced polymer (CFRP) composites exhibit excellent characteristics such as light weight, high specific strength, stiffness, and chemical stability, making them customizable to meet the demands of various sectors automotive, aerospace, defense, biomedical, energy industries. However, inert surface carbon fibers (CFs) results in a poor interface compatibility with matrices, leading numerous interfacial defects pores prepared CFRP composites. These drawbacks significantly limit application high‐end fields. The higher area smaller size nanomaterials provide multiple advantages for high‐performance that enhance mechanical properties, impact resistance adhesion between matrix. Hence, this review firstly summarizes behavior enhancement mechanisms Subsequently, we comprehensively recent advances nanomaterials‐modified composites, including carbon‐based nanoparticles, silicon‐based metal nanomaterials, et al. Besides, also present applications emerging fields, military, sports equipment, medical, etc. Finally, prospected challenges future development trends aiming new ideas insights research on nanomaterial modifications promote Highlights theory is summarized. Different types nanoparticles can be used reinforcement modification methods are reviewed. Application fields presented. Challenges directions preparation proposed.
Язык: Английский
Процитировано
11
Materials Today Bio, Год журнала: 2024, Номер 25, С. 100976 - 100976
Опубликована: Янв. 28, 2024
Osteonecrosis is a devastating orthopedic disease in clinic that generally occurs the femoral head associating with corticosteroid use up to 49 % patients. In particular, glucocorticoids induced osteonecrosis of closely related local immune response characterized by abnormal macrophage activation and inflammatory cell infiltration at necrotic site, forming pro-inflammatory microenvironment dominated M1 macrophages, thus leads failure bone repair regeneration. Here, we report regeneration strategy constructs an regulatory biomaterial platform using injectable thiolated hyaluronic acid hydrogel lithium-doped nano-hydroxyapatite (Li-nHA@Gel) delivery for treatment. Li-nHA@Gel achieved sustain longterm release Li ions, which might enhance M2 polarization through JAK1/STAT6/STAT3 signaling pathway, following pro-repair mediated enhancement osteogenic angiogenic differentiation. Moreover, both vitro vivo studies indicated enhanced polarization, osteogenesis, angiogenesis, promoted blood vessel formation. Taken together, this novel immunomodulatory promotes enhancing angiogenesis could be promising
Язык: Английский
Процитировано
10
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 682 - 698
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
9
Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
Background Immunogenic cell death (ICD) induced by different cancer treatments has been widely evaluated to recruit immune cells and trigger the specific antitumor immunity. However, associated fibroblasts (CAFs) can hinder invasion of polarize recruited monocytes M2-type macrophages, which greatly restrict efficacy immunotherapy (IT). Methods In this study, an injectable hydrogel copper (Cu) designed contain antibody PD-L1 nitric oxide (NO) donor. The therapeutic was studied in 4T1 CAFs vitro tumor-bearing mice vivo. effects on cytotoxic T lymphocytes, dendritic (DCs) macrophages were analyzed flow cytometry. Enzyme-linked immunosorbent assay, immunofluorescence transcriptome analyses also performed evaluate underlying mechanism. Results Due absorbance Cu with near-infrared laser irradiation, exhibits persistent photothermal effect kill cells. addition, shows Fenton-like reaction produce reactive oxygen species as chemodynamic therapy, thereby enhancing treatment amplifying ICD. More interestingly, we have found that released NO significantly increase depletion reduce proportion vitro. Furthermore, due amplify ICD, effectively infiltration reverse immunosuppressive tumor microenvironment (TME) regulating enhance anti-PD-L1 Conclusions ion self-assembled could via ICD CAFs. It provides a novel strategy provoke robust response for clinical immunotherapy. Graphical Abstract
Язык: Английский
Процитировано
20
Molecules, Год журнала: 2023, Номер 28(7), С. 2920 - 2920
Опубликована: Март 24, 2023
Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by FDA cancer therapy was cisplatin 1978. Even nearly four and a half decades of trials, there has been no significant improvement osteosarcoma (OS) therapy. In fact, many have developed, but problem raised remains unresolved. This motivates us elucidate possibilities copper zinc (CuZn) combination replace MBD. Thus, anti-chemoresistance properties CuZn their physiological functions OS are highlighted. Herein, we summarise chelators, main organic solvents, ligand structures that involved properties. Through this review, it rational discuss ligands' roles as biosensors drug delivery systems. Hereafter, an in-depth understanding redox photoactive function relationships provided. disadvantage other cannot be elaborated on here. As result, review being which expected intensify with higher cure rates. Nonetheless, advancement intends solve major obstacle towards clinical efficacy.
Язык: Английский
Процитировано
18
Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215969 - 215969
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
7
Advanced Functional Materials, Год журнала: 2024, Номер 34(26)
Опубликована: Янв. 9, 2024
Abstract In situ tumor vaccines (ISTVs) hold great potential in immunotherapy, however, three major obstacles, including inadequate endogenous antigen uptake by dendritic cells (DCs), weak T‐cell immune responses, and stubborn immunosuppressive microenvironment (TME), still need to be fully addressed. Herein, a trifecta nanovaccine (TriNV) with TME‐responsive transformable ability is developed tri‐boost antitumor immunity. First, sufficient tumor‐associated antigens (TAAs) are liberated after immunogenic cell death induced via TriNV‐based photoimmunotherapy. the TME, soft‐transformed TriNV improves of TAAs DCs enhance acquired Second, self‐adjuvating released Mn 2+ synergistically promote DC maturation macrophage M1 polarization augmenting stimulator interferon genes activation further amplify responses. Moreover, decomposition MnO 2 within core exhausts glutathione facilitates O release alleviate hypoxia thereby overcoming chemical obstacles TME mitigate immunosuppression. Thus, remarkably eradicates primary tumors inhibits distant metastasis, thus demonstrating as feasible effective ISTV nanoplatform for combating poorly solid tumors.
Язык: Английский
Процитировано
6