Nano Energy, Год журнала: 2024, Номер 127, С. 109732 - 109732
Опубликована: Май 15, 2024
Язык: Английский
Nature Reviews Materials, Год журнала: 2024, Номер 9(8), С. 550 - 566
Опубликована: Июнь 17, 2024
Язык: Английский
Процитировано
79
Materials Today Bio, Год журнала: 2024, Номер 24, С. 100948 - 100948
Опубликована: Янв. 5, 2024
Articular cartilage injury is a frequent worldwide disease, while effective treatment urgently needed. Due to lack of blood vessels and nerves, the ability self-repair limited. Despite availability various clinical treatments, unfavorable prognoses complications remain prevalent. However, advent tissue engineering regenerative medicine has generated considerable interests in using biomaterials for articular repair. Nevertheless, there remains notable scarcity comprehensive reviews that provide an in-depth exploration strategies applications. Herein, we present overview primary bioactive substances from perspective repair cartilage. The include regeneration, substitution, immunization. We comprehensively delineate influence mechanically supportive scaffolds on cellular behavior, shedding light emerging scaffold technologies, including stimuli-responsive smart scaffolds, 3D-printed bionic scaffolds. Biologically active substances, factors, stem cells, extracellular vesicles (EVs), organoids, are elucidated their roles regulating activity chondrocytes. Furthermore, composite produced industrially put into use, also explicitly presented. This review offers innovative solutions treating ailments emphasizes potential translation.
Язык: Английский
Процитировано
58
Advanced Materials, Год журнала: 2023, Номер 35(47)
Опубликована: Авг. 7, 2023
Chronic wounds have become a significant threat to people's physical and mental health increased the burden of social medical care. Intelligent wound dressing (IWD) with condition monitoring closed-loop on-demand drug therapy can shorten healing process alleviate patient suffering. However, single-function dressings cannot meet current needs chronic treatment. Here, wearable IWD consisting exudate management, sensor monitoring, therapy, flexible circuit modules is reported, which achieve effective synergy between management therapy. The attached site, spontaneously pumped into microfluidic channel for storage. Meanwhile, detect state through temperature humidity sensor, use this as feedback control liquid metal (LM) heater smartphone, thereby realizing release from hydrogel. In mouse model infected wounds, accelerates by reducing inflammatory responses, promoting angiogenesis collagen deposition.
Язык: Английский
Процитировано
54
Nano Energy, Год журнала: 2023, Номер 116, С. 108787 - 108787
Опубликована: Авг. 15, 2023
Язык: Английский
Процитировано
42
Advanced Functional Materials, Год журнала: 2024, Номер 34(40)
Опубликована: Апрель 16, 2024
Abstract Electric signal accelerates full‐thickness wound healing in the clinic, which is usually generated by a large power generation system and requires delicate control authorized personnel. Here, self‐powered flexible biocompatible thermoelectric device with exceptionally high efficiency developed. It generates 10 mV voltage at temperature gradient of K, outperforming all reported devices. Accordingly, it can directly efficiently convert omnipresent heat skin to electricity microvolt level. The output activates upregulates expression Piezo1‐mediated pathways that are associated tissue regeneration, accelerating cell migration proliferation vitro 4 days faster vivo. Importantly, fast‐heals without involving any additional electric circuit such as an amplifier. These advantages will revolutionize designing wearable bioelectronics for diagnosing, monitoring, treating various pathological conditions employing heat.
Язык: Английский
Процитировано
19
Nano Energy, Год журнала: 2024, Номер 123, С. 109383 - 109383
Опубликована: Фев. 11, 2024
Triboelectric Nanogenerators (TENG), which convert mechanical energy into electrical pulses, are envisioned to lead future harvesting and self-powered sensing applications in wearable IoT sectors. While optimisation of most parameters related TENG is well understood, the impact dielectric constant, fundamental their output generation, still a highly debated topic. The intrinsic constant on performance extremely difficult assess experimentally, as it closely associates with other like surface charge density that can alter outputs. Herein, for first time, we present study fully characterise First, theoretical methods used investigate outputs against increasing constant. A novel experimental technique introduced using an array liquid filler materials, providing unique pathway systematically tune without impacting parameters. This study, unveils load-dependent behaviour generation along several previously unreported trends. By tuning demonstrate up 122% (theoretical) 28% (experimental) increments power output, paving way enhanced optimisation.
Язык: Английский
Процитировано
17
Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149643 - 149643
Опубликована: Фев. 17, 2024
Язык: Английский
Процитировано
17
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Abstract Chronic wounds are a common complication of diabetes, causing significant inconvenience, persistent pain, and economic burden to patients. Real‐time monitoring wound status timely treatment with intelligent dressings is promising way treat infection accelerate healing. However, the traditional make it difficult simultaneously maintain true state meet dynamic needs chronic wounds. Herein, multifunctional self‐powered patch (MSPP) featured antibacterial, hypoglycemic, electrical stimulation designed promote healing real‐time status, in which laser‐induced nanozyme electrodes prepared situ through laser scanning technology construct highly stable nanozyme‐based glucose biofuel cells (GBFCs). Enzymatic cascade reaction GBFCs can use local hyperglycemia produce reactive oxygen species effective antibacterial properties, reduce while generating microcurrent, further diabetes In just 10 days, patch‐treated group achieves 100% shrinkage. Meanwhile, pH sensing module MSPP also monitor fluctuations correct test results, improving accuracy. brief, construction provides solutions for developing closed‐loop biomedical systems that integrate monitoring, diagnosis, treatment.
Язык: Английский
Процитировано
4
iScience, Год журнала: 2025, Номер 28(2), С. 111763 - 111763
Опубликована: Янв. 7, 2025
Recent years have witnessed tremendous advances in wearable sensors, which play an essential role personalized healthcare for their ability real-time sensing and detection of human health information. Nanozymes, capable mimicking the functions natural enzymes addressing limitations, possess unique advantages such as structural stability, low cost, ease mass production, making them particularly beneficial constructing recognition units biosensors. In this review, we aim to delineate latest advancements nanozymes development biosensors, focusing on key developments nanozyme immobilization strategies, technologies, biomedical applications. The review also highlights current challenges future perspectives. Ultimately, it aims provide insights research endeavors rapidly evolving area.
Язык: Английский
Процитировано
3
Materials Today, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2