Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Март 11, 2025

This systematic review explores the hypothesis that various lipid categories and metabolism-related genomic variations link to mental disorders, seeking potential clinically useful markers. We searched PubMed, Scopus, PsycInfo databases until October 12th, 2024, using terms related lipidomics, lipid-related genomics, different i.e., Major Depressive Disorder (MDD), Bipolar (BD), Schizophrenia (SCZ), Obsessive–Compulsive (OCD). Eligible studies were assessed. Extracted data included author, year, methodology, outcomes, genes, lipids linked disorders. Bias evidence certainty evaluated. The adhered PRISMA (Preferred Reporting Items for Systematic Reviews Meta-Analyses) guidelines a registered protocol (PROSPERO: CRD42023438862). A total of 27 included. SCZ showed alterations in 77 lipids, including triglycerides (TG), ceramides, phosphatidylcholine, while MDD BD exhibited 97 47 altered respectively, with overlap among Shared such as ABCA13, DGKZ, FADS, pathways involving inflammation, metabolism, mitochondrial function identified. OCD was associated sphingolipid signaling peroxisomal metabolism. Lipid signatures MDD, BD, shed light on underlying processes. Further research is needed validate biomarkers refine their clinical applications precision psychiatry.

Язык: Английский

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Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions

Metabolites, Год журнала: 2025, Номер 15(1), С. 10 - 10

Опубликована: Янв. 2, 2025

Huntington's disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions. Despite limited understanding its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in huntingtin gene (HTT) as critical factor. The development innovative strategies imperative for early detection predictive biomarkers, enabling timely intervention mitigating irreversible cellular damage. Lipidomics, comprehensive analytical approach, emerged an indispensable tool systematically characterizing lipid profiles elucidating their role pathology. A MedLine search was performed to identify studies that use lipidomics characterization HD. Search terms included "Huntington disease"; "lipidomics"; "biomarker discovery"; "NMR"; "Mass spectrometry". This review highlights significance HD diagnosis treatment, exploring changes brain lipids Recent breakthroughs techniques, particularly mass spectrometry NMR spectroscopy, have revolutionized research, researchers gain deeper insights into complex lipidome brain. broad spectrum alterations vital precise diagnostic evaluation effective management. integration with artificial intelligence interdisciplinary collaboration holds promise addressing clinical variability

Язык: Английский

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Diverse Colonisation and Disease Associations of the Human Commensal Malassezia: Our Body's Secret Tenant

Mycoses, Год журнала: 2025, Номер 68(1)

Опубликована: Янв. 1, 2025

ABSTRACT A niche in the context of microorganisms defines specific ecological role or habitat inhabited by microbial species within an ecosystem. For human commensal Malassezia , skin surface is considered its primary niche, where it adapts to environment utilising lipids as main carbon and energy source. However pathogenic characteristics include production allergens, immune modulation excessive lipid utilisation, which result several diseases such pityriasis versicolor, seborrheic dermatitis, folliculitis atopic dermatitis. Recent studies have revealed colonisation internal organs, including lungs, gut, genitourinary tract, eyes, ears breast milk. In these associated with linked respiratory conditions, neurological disorders, gastrointestinal genital infections. The system plays a critical shaping prevalence, factors like, suppressive drugs underlying health conditions influencing susceptibility. Accurate diagnosis ‐related disorders challenging due unique growth requirements, but molecular fingerprinting assays sequencing methods, particularly ITS sequencing, offer precise identification. Treatment involves antifungal drugs, corticosteroids phytocompounds, yet recurrent infections highlight need for more targeted therapeutic strategies addressing 's characteristics. Understanding complex interactions between host organs crucial diagnosis, treatment prevention exploring potentially beneficial roles disease. This review highlights current findings on intricate diverse ecosystem body, underscoring complexity associations emphasising their multifaceted

Язык: Английский

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Molecular and biophysical features of hippocampal “lipid rafts aging” are modified by dietary n‐3 long‐chain polyunsaturated fatty acids

Aging Cell, Год журнала: 2023, Номер 22(8)

Опубликована: Май 30, 2023

Abstract “Lipid raft aging” in nerve cells represents an early event the development of aging‐related neurodegenerative diseases, such as Alzheimer's disease. Lipid rafts are key elements synaptic plasticity, and their modification with aging alters interactions distribution signaling molecules, glutamate receptors ion channels involved memory formation, eventually leading to cognitive decline. In present study, we have analyzed, vivo, effects dietary supplementation n‐3 LCPUFA on lipid structure, membrane microviscosity, domain organization, partitioning ionotropic metabotropic hippocampal raffs female mice. The results revealed several signatures “lipid old mice fed control diets, consisting depletion LCPUFA, unsaturation, along increased levels saturates, plasmalogens, sterol esters, well altered relevant indexes. These changes were paralleled by microviscosity raft/non‐raft (R/NR) AMPA‐R mGluR5. Administration diet caused partial reversion fatty acid alterations found aged returned values young animals. Paralleling these findings, accumulated mGluR5, NMDA‐R, ASIC2, R/NR proportions, which collectively indicate plasticity. Unexpectedly, this also modified lipidome dimension rafts, redistribution acid‐sensing likely modulating functionality formation reluctance age‐associated

Язык: Английский

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Lipid homeostasis is essential for a maximal ER stress response

eLife, Год журнала: 2023, Номер 12

Опубликована: Июль 25, 2023

Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein synthesis, making its function essential both homeostasis. However, it less clear how quality may impact each other. Here, we identified let-767, putative hydroxysteroid dehydrogenase Caenorhabditis elegans, as an gene ER Knockdown of let-767 reduces stores, alters morphology lipid-dependent manner, blocks induction the Unfolded Protein Response (UPRER). Interestingly, global reduction lipogenic pathways restores UPRER animals reduced let-767. Specifically, find that supplementation 3-oxoacyl, predicted metabolite directly upstream sufficient to block UPRER. This study highlights novel interaction through which changes can alter cell's response protein-induced stress.

Язык: Английский

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Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives

Physiological Reviews, Год журнала: 2024, Номер 105(1), С. 137 - 207

Опубликована: Июль 11, 2024

Lipids represent the most abundant molecular type in brain, with a fat content of ∼60% dry brain weight humans. Despite this fact, little attention has been paid to circumscribe dynamic role lipids function and disease. Membrane such as cholesterol, phosphoinositide, sphingolipids, arachidonic acid, endocannabinoids finely regulate both synaptic receptors ion channels that ensure critical neural functions. After brief introduction on their respective properties, we review here regulating channel activity, action potential propagation, neuronal development, functional plasticity contribution development neurological neuropsychiatric diseases. We also provide possible directions for future research lipid

Язык: Английский

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Plasma lipidomic profiling reveals six candidate biomarkers for the prediction of incident stroke in patients with hypertension

Metabolomics, Год журнала: 2024, Номер 20(1)

Опубликована: Янв. 5, 2024

Язык: Английский

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Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers

Metabolites, Год журнала: 2024, Номер 14(2), С. 80 - 80

Опубликована: Янв. 23, 2024

Lipids are a crucial component of the human brain, serving important structural and functional roles. They involved in cell function, myelination neuronal projections, neurotransmission, neural plasticity, energy metabolism, neuroinflammation. Despite their significance, role lipids development mental disorders has not been well understood. This review focused on potential use as blood biomarkers for common illnesses, such major depressive disorder, anxiety disorders, bipolar schizophrenia. also discussed impact commonly used psychiatric medications, neuroleptics antidepressants, lipid metabolism. The obtained data suggested that could be useful diagnosing diseases, but further research is needed to better understand associations between identify specific biomarker combinations each disease.

Язык: Английский

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Study on the action mechanism of Buyang Huanwu Decoction against ischemic stroke based on S1P/S1PR1/PI3K/Akt signaling pathway

Journal of Ethnopharmacology, Год журнала: 2023, Номер 312, С. 116471 - 116471

Опубликована: Апрель 6, 2023

Язык: Английский

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Unconventional T cells in brain homeostasis, injury and neurodegeneration

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Окт. 3, 2023

The interaction between peripheral immune cells and the brain is an important component of neuroimmune axis. Unconventional T cells, which include natural killer (NKT) mucosal-associated invariant (MAIT) γδ other poorly defined subsets, are a special group lymphocytes that recognize wide range nonpolymorphic ligands connection adaptive innate immunity. Recently, increasing number complex functions these unconventional in homeostasis various disorders have been revealed. In this review, we describe classification effector function review evidence for involvement regulation homeostasis, summarize roles mechanisms injury neurodegeneration, discuss immunotherapeutic potential as well future research goals. Insight processes can shed light on cell immunity diseases provide new clues therapeutic approaches targeting neurodegeneration.

Язык: Английский

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