The dynamic process of mRNA delivery by lipid nanoparticles in vivo

Nano Today, Год журнала: 2024, Номер 57, С. 102325 - 102325

Опубликована: Май 30, 2024

Язык: Английский

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Transdermal gene delivery

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 516 - 529

Опубликована: Июнь 12, 2024

Язык: Английский

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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour model

EBioMedicine, Год журнала: 2025, Номер 112, С. 105543 - 105543

Опубликована: Янв. 9, 2025

Язык: Английский

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A Polymeric mRNA Vaccine Featuring Enhanced Site‐Specific mRNA Delivery and Inherent STING‐Stimulating Performance for Tumor Immunotherapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract The development of mRNA delivery carriers with innate immune stimulation functions has emerged as a focal point in the field vaccines. Nonetheless, expression specific sites and at are prerequisites for ensuring safety Based on synthetic PEIRs library, this study identifies an innovative carrier named POctS following characteristics: 1) simultaneously possessing high efficiency stimulator interferon genes (STING) function. 2) Leveraging distinctive site‐specific capabilities POctS, activation responses designated achieved, minimizing formulation toxicity maximizing vaccine performance. 3) Tailoring two types vaccines based according to infiltration status different tumors. Briefly, POctS‐loading ovalbumin (OVA) tumor antigen achieves prevention treatment melanoma mice. Further, mixed lineage kinase domain‐like protein (MLKL) situ effectively treats orthotopic pancreatic cancer This offers feasible vaccine‐based immunotherapy strategy various

Язык: Английский

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Bioengineered nanotechnology for nucleic acid delivery

Journal of Controlled Release, Год журнала: 2023, Номер 364, С. 124 - 141

Опубликована: Окт. 27, 2023

Язык: Английский

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