Emerging contaminants: A One Health perspective

The Innovation, Год журнала: 2024, Номер 5(4), С. 100612 - 100612

Опубликована: Март 13, 2024

Язык: Английский

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Minimum Minutes Machine-Learning Microfluidic Microbe Monitoring Method (M7)

ACS Nano, Год журнала: 2024, Номер 18(6), С. 4862 - 4870

Опубликована: Янв. 17, 2024

Frequent outbreaks of viral diseases have brought substantial negative impacts on society and the economy, they are very difficult to detect, as concentration aerosols in air is low composition complex. The traditional detection method manually collection re-detection, being cumbersome time-consuming. Here we propose a virus aerosol based microfluidic inertial separation spectroscopic analysis technology rapidly accurately detect particles air. chip designed principles laminar flow characteristics, resulting an average efficiency 95.99% for 2 μm particles. We build composite spectrometer platform capture spectral information dynamically. By employing machine-learning techniques, can classify different types entire experiment took less than 30 min compared with hours by PCR detection. Furthermore, our model achieves accuracy 97.87% identifying aerosols, which comparable results obtained from

Язык: Английский

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Differentiating the impacts of ambient temperature on pneumonia mortality of various infectious causes: a nationwide, individual-level, case-crossover study

EBioMedicine, Год журнала: 2023, Номер 98, С. 104854 - 104854

Опубликована: Окт. 28, 2023

It remains unknown how ambient temperature impact pneumonia of various infectious causes.

Язык: Английский

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Quantification of Particle-Associated Viruses in Secondary Treated Wastewater Effluent

Food and Environmental Virology, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 15, 2025

Язык: Английский

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Lung-on-a-chip: From design principles to disease applications

Biomicrofluidics, Год журнала: 2025, Номер 19(2)

Опубликована: Март 1, 2025

To address the growing need for accurate lung models, particularly in light of respiratory diseases, cancer, and COVID-19 pandemic, lung-on-a-chip technology is emerging as a powerful alternative. Lung-on-a-chip devices utilize microfluidics to create three-dimensional models that closely mimic key physiological features human lung, such air-liquid interface, mechanical forces associated with respiration, fluid dynamics. This review provides comprehensive overview fundamental components systems, diverse fabrication methods used construct these complex summary their wide range applications disease modeling aerosol deposition studies. Despite existing challenges, hold immense potential advancing personalized medicine, drug development, prevention, offering transformative approach health research.

Язык: Английский

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Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 27, 2024

Many lung immune cells are known to respond inhaled particulate matter. However, current responses cannot explain how particles induce thrombosis in the and they translocate distant organs. Here, we demonstrate that megakaryocytes (MKs) alveolar interstitial regions display location-determined characteristics act as crucial responders particles. They move rapidly engulf become activated with upregulation inflammatory thrombopoiesis. Comprehensive vivo, vitro ex vivo results unraveled MKs were involved particle-induced damages shed particle-containing platelets into blood circulation. Moreover, MK-derived exhibited faster clotting, stronger adhesion than normal resting platelets, inherited engulfed from parent assist extrapulmonary particle transportation. Our findings collectively highlight specific of towards their roles facilitating translocation lungs organs for clearance. authors show airborne generate particle-bearing providing a path transfer out extraplumonary

Язык: Английский

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Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract

European Respiratory Review, Год журнала: 2024, Номер 33(173), С. 230259 - 230259

Опубликована: Июль 1, 2024

Particulate matter with a diameter ≤2.5 μm (PM 2.5 ) poses substantial global challenge, growing recognition of pathogens contributing to diseases associated exposure PM . Recent studies have focused on , which impairs the immune cells in response microbial infections and potentially contributes development severe respiratory tract. Accordingly, changes function microecology mediated by are important factors that enhance risk pathogenesis. These garnered significant interest. In this review, we summarise recent potential mechanisms involved -mediated system disruption exacerbation pathogenesis We also discuss crucial areas for future research address gaps our understanding develop effective strategies combat adverse health effects

Язык: Английский

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Lung injuries induced by ozone exposure in female mice: Potential roles of the gut and lung microbes

Environment International, Год журнала: 2024, Номер 183, С. 108422 - 108422

Опубликована: Янв. 1, 2024

Ozone (O3) is one of the most harmful pollutants affecting health. However, potential effects O3 exposure on microbes in gut–lung axis related to lung injuries remain elusive. In this study, we exposed female mice 0-, 0.5- and 1-ppm for 28 days, followed by routine blood tests, function tests histopathological examination colon, nasal cavity lung. Mouse faeces lungs were collected 16s rRNA sequencing assess overall microbiological profile screen key differential (DEMs). The DEMs faecal samples Butyricimonas, Rikenellaceae RC9 Escherichia-Shigella, whereas those DNF00809, Fluviicola, Bryobacter, Family XII AD3011 group, Sharpea, MND1 unclassified Phycisphaeraceae. After a search microbe–disease databases, these found be associated with diseases such as neoplasms, cystic fibrosis, pneumonia, chronic obstructive pulmonary disease, respiratory distress syndrome bronchiectasis. Subsequently, used transcriptomic data from Gene Expression Omnibus (GEO) conditions similar study cross-reference Comparative Toxicogenomic Database (CTD). Il-6 Ccl2 identified causative genes validated. findings suggest that leads significant changes microbial composition gut lungs. These are increased levels inflammatory factors impaired function, resulting an risk disease. Altogether, provides novel insights into role present exposure-induced injury.

Язык: Английский

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Airway bacterial microbiome signatures correlate with occupational pneumoconiosis progression

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116875 - 116875

Опубликована: Авг. 13, 2024

Recent evidence has pinpointed a key role of the microbiome in human respiratory health and disease. However, significant knowledge gaps still exist regarding connection between bacterial communities adverse effects caused by particulate matters (PMs). Here, we characterized along different airway sites occupational pneumoconiosis (OP) patients. The sequencing data revealed that OP patients exhibited distinct dysbiosis composition function microbiota. To extents, there was an overall increase colonization microbiota, such as Streptococcus, implying possible intrusion pathway provided exogenous PMs. Compared to those healthy subjects, unhealthy living habits (i.e., smoking) had greater impact on changes Importantly, associations community disease indicators indicated specific species, including Prevotella, Actinobacillus, Leptotrichia, might be surrogate markers progression. Collectively, our results highlighted potential participation microbiota pathogenesis diseases helped discovery microbiome-based diagnostics for PM-induced disorders.

Язык: Английский

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Global meta-analysis of short-term associations between ambient temperature and pathogen-specific respiratory infections, 2004 to 2023

Eurosurveillance, Год журнала: 2025, Номер 30(11)

Опубликована: Март 20, 2025

Background Ambient temperature may affect respiratory health, while the sensitivity of infections be pathogen-dependent. Aims We sought to explore pathogen-specific associations between ambient and infections. Methods searched nine databases for a random-effects meta-analysis pool relative risk (RR) infection by pathogen per 1° C rise, compared populations unexposed same temperature. conducted analyses, subgroup analyses meta-regression. Results A total 137 studies were eligible meta-analysis. The pooled single-study estimates revealed that incidence syncytial virus (RR = 0.14; 95% confidence interval (CI): 0.09–0.23), influenza (IV) 0.40; CI: 0.27–0.61), human metapneumovirus 0.48; 0.32–0.73), coronavirus (HCoV) 0.21; 0.07–0.61) SARS-CoV-2 0.52; 0.35–0.78) decreased parainfluenza (HPIV) 2.35; 1.46–3.77), bocavirus (HBoV) 1.86; 1.04–3.32) MERS-CoV 1.05; 1.04–1.07) increased. was lower IVA, IVB, HCoV-229E HCoV-OC43, HPIV-3, HBoV-1 at increased risk. Streptococcus pyogenes pharyngitis 0.46; 0.30–0.69) Pseudomonas aeruginosa 1.04; 1.03–1.05) Legionella pneumophila 2.69; 1.11–6.53) Conclusions Temperature can vary with specific type subtype causes infection. As climatic conditions will become warmer, public health policy makers should act develop adaptation strategies.

Язык: Английский

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