Novel strategies for modulating the gut microbiome for cancer therapy

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 210, С. 115332 - 115332

Опубликована: Май 15, 2024

Язык: Английский

---

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Nutrients, Год журнала: 2024, Номер 16(10), С. 1500 - 1500

Опубликована: Май 16, 2024

As the population ages, incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted importance gut microbial homeostasis its impact on brain functions, commonly referred as gut–brain axis, in maintaining overall health wellbeing. Nonetheless, mechanisms by which system acts remains poorly defined. In review, we will explore how (poly)phenols, a class natural compounds found many plant-based foods beverages, can modulate thereby promote neural health. While evidence indicates beneficial role (poly)phenol consumption part balanced diet, human scarce mechanistic insight still lacking. regard, make case that dietary (poly)phenols should be further explored establish their therapeutic efficacy through modulation with much greater emphasis carefully designed interventions.

Язык: Английский

---

Impact of polyphenol-loaded edible starch nanomaterials on antioxidant capacity and gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130979 - 130979

Опубликована: Март 19, 2024

Язык: Английский

---

Plant-inspired visible-light-driven bioenergetic hydrogels for chronic wound healing

Bioactive Materials, Год журнала: 2024, Номер 41, С. 523 - 536

Опубликована: Авг. 10, 2024

Язык: Английский

---

Recent development of micro-nano carriers for oral antineoplastic drug delivery

Materials Today Bio, Год журнала: 2025, Номер 30, С. 101445 - 101445

Опубликована: Янв. 5, 2025

Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral stands prevailing utilized method delivering chemotherapy drugs. However, majority anti-tumor medications exhibit limited solubility permeability, poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy chemotherapy. Therefore, more micro-nano drug delivery carriers have been developed used effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate administration, ultimately improve efficacy. In this paper, we first discuss effects various biological barriers on approach. Then, development based biomedical components, such micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, current dilemma potential clinical treatment discussed. The primary objective review introduce methods serve point reference advancement novel carriers, with ultimate goal informing future applications.

Язык: Английский

---

Oxygen‐Propelled Dual‐Modular Microneedles with Dopamine‐Enhanced RNA Delivery for Regulating Each Stage of Diabetic Wounds

Small, Год журнала: 2024, Номер 20(46)

Опубликована: Авг. 6, 2024

Abstract Diabetic wounds are characterized by the disruption and cessation of essential healing stages, which include hemostasis, inflammation, proliferation, remodeling. However, traditional treatments for diabetic concentrate on individual stages process. Herein, this study utilizes mask‐mediated sequential polymerization varied cross‐linking techniques to develop dual‐modular microneedles (MNs) with fast‐ slow‐module, exhibiting varying degradation rates tailored full spectrum wound healing. First, MNs incorporating calcium ions dopamine synergistically promote rapid hemostasis. Second, fast‐module physically cross‐linked rapidly D‐mannose/dopamine‐enhanced tripolyphosphate‐quaternized chitosan (mDTC) nanoparticles (NPs) loaded microRNA‐147 (miRNA‐147) manage inflammation oxidative stress in wounds. Additionally, these NPs enhances their internalization safeguards miRNA‐147 from RNase degradation. Finally, slow‐module chemically facilitate continuous release deferoxamine (DFO) dopamine, accelerating angiogenesis tissue regeneration during proliferation remodeling stages. Manganese/dopamine‐enhanced peroxide within initiate a blast‐like generation oxygen bubbles, not only enhancing delivery miRNA‐mDTC DFO but also alleviating hypoxia. Consequently, instrumental promoting complete through all

Язык: Английский

---

Natural polyphenolic antibacterial bio-adhesives for infected wound healing

Biomaterials Science, Год журнала: 2024, Номер 12(9), С. 2282 - 2291

Опубликована: Янв. 1, 2024

Polyphenolic antibacterial bio-adhesives were synthesised via polyphenols and acid anhydrides without solvent or catalyst. Upon heating, these adhesives could induce strong adhesion onto various substrates, while demonstrating excellent antibacterial, antiinfection biodegradability properties.

Язык: Английский

---

Glutathione-responsive nanoplatforms trigger gaseous intervention of intestinal inflammation through TLR4/MD2/MyD88/NF-κB/iNOS pathway activation and gut microbiota modulation

Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152849 - 152849

Опубликована: Июнь 5, 2024

Язык: Английский

---

Fractional extraction phenolics from c. Oleifera seed kernels exhibited anti-inflammatory effect via PI3K/Akt/NF-κB signaling pathway under Caco-2/RAW264.7 co-culture cell model

Food Research International, Год журнала: 2024, Номер 197, С. 115268 - 115268

Опубликована: Ноя. 5, 2024

Язык: Английский

---

Synthesis, characterization, and antibacterial effect of St. John's wort oil loaded chitosan hydrogel

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129444 - 129444

Опубликована: Янв. 21, 2024

Язык: Английский

---